HK1064384A1 - Preparation of aminopyrimidine compounds - Google Patents

Preparation of aminopyrimidine compounds

Info

Publication number
HK1064384A1
HK1064384A1 HK04107242A HK04107242A HK1064384A1 HK 1064384 A1 HK1064384 A1 HK 1064384A1 HK 04107242 A HK04107242 A HK 04107242A HK 04107242 A HK04107242 A HK 04107242A HK 1064384 A1 HK1064384 A1 HK 1064384A1
Authority
HK
Hong Kong
Prior art keywords
preparation
aminopyrimidine compounds
aminopyrimidine
compounds
Prior art date
Application number
HK04107242A
Other languages
English (en)
Inventor
Akio Matsushita
Mizuho Oda
Yasuhiro Kawachi
-Ichi Jun Chik
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of HK1064384A1 publication Critical patent/HK1064384A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK04107242A 2001-07-13 2004-09-20 Preparation of aminopyrimidine compounds HK1064384A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2001213418 2001-07-13
JP2001213417 2001-07-13
JP2001310900 2001-10-09
JP2001360339 2001-11-27
JP2002007015 2002-01-16
JP2002042076 2002-02-19
PCT/JP2002/007129 WO2003006439A1 (en) 2001-07-13 2002-07-12 Preparation of aminopyrimidine compounds

Publications (1)

Publication Number Publication Date
HK1064384A1 true HK1064384A1 (en) 2005-01-28

Family

ID=27554967

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04107242A HK1064384A1 (en) 2001-07-13 2004-09-20 Preparation of aminopyrimidine compounds

Country Status (28)

Country Link
US (4) US7304156B2 (zh)
EP (1) EP1417180B1 (zh)
JP (2) JP4359141B2 (zh)
KR (1) KR100888408B1 (zh)
CN (2) CN100349877C (zh)
AR (2) AR034772A1 (zh)
AT (1) ATE349431T1 (zh)
AU (1) AU2002318041B2 (zh)
BR (1) BR0211072A (zh)
CA (1) CA2453505C (zh)
CO (1) CO5560574A2 (zh)
CY (1) CY1107551T1 (zh)
DE (1) DE60217126T2 (zh)
DK (1) DK1417180T3 (zh)
EG (1) EG24848A (zh)
ES (1) ES2278032T3 (zh)
HK (1) HK1064384A1 (zh)
HU (1) HUP0401248A3 (zh)
IL (2) IL159741A0 (zh)
IS (1) IS2399B (zh)
MX (1) MXPA04000322A (zh)
MY (1) MY133579A (zh)
NO (1) NO326173B1 (zh)
NZ (1) NZ531033A (zh)
PL (1) PL366831A1 (zh)
PT (1) PT1417180E (zh)
SI (1) SI1417180T1 (zh)
WO (1) WO2003006439A1 (zh)

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CN102584717B (zh) * 2011-01-17 2014-12-10 浙江九洲药业股份有限公司 用于制备罗苏伐他汀的中间体及相关制备方法和用途
CN103483269B (zh) * 2012-06-13 2016-04-27 上海迪赛诺药业有限公司 瑞舒伐他汀钙及其中间体的制备方法
WO2013185309A1 (zh) * 2012-06-13 2013-12-19 上海迪赛诺药业有限公司 瑞舒伐他汀钙及其中间体的制备方法
CN103864697A (zh) * 2012-12-11 2014-06-18 润泽制药(苏州)有限公司 瑞舒伐中间体主链醇的制备方法
CN104059024B (zh) * 2014-06-16 2016-04-06 浙江大学 瑞舒伐他汀中间体的制备方法及中间体化合物
MX368055B (es) * 2015-01-23 2019-09-18 Dsm Sinochem Pharm Nl Bv Procedimiento mejorado para preparar un precursor de estatina.
CN104817505A (zh) * 2015-04-23 2015-08-05 南京博优康远生物医药科技有限公司 一种制备n-[4-(4-氟苯基)-5-羟甲基-6-异丙基-嘧啶-2-基]-n-甲基甲磺酰胺的方法
CN109912522B (zh) * 2017-12-12 2021-04-13 北京颖泰嘉和生物科技股份有限公司 制备三唑啉硫酮化合物的方法
CN109081815A (zh) * 2018-11-12 2018-12-25 甘肃农业大学 一种新型亲电试剂甲磺酸嘧啶酯的制备方法
CN111138369A (zh) * 2019-12-17 2020-05-12 上海雅本化学有限公司 瑞舒法他汀中间体的制备方法
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CN112174898B (zh) * 2020-11-06 2021-05-04 浙江宏元药业股份有限公司 一种连续氧化二氢嘧啶酮制备羟基嘧啶的新方法
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Also Published As

Publication number Publication date
NO20040122L (no) 2004-01-12
US20110160455A1 (en) 2011-06-30
EG24848A (en) 2010-10-27
DE60217126T2 (de) 2007-10-04
CN1527821A (zh) 2004-09-08
JP2009167167A (ja) 2009-07-30
US7816528B2 (en) 2010-10-19
MY133579A (en) 2007-11-30
US20080058520A1 (en) 2008-03-06
IS2399B (is) 2008-09-15
IS7103A (is) 2004-01-12
BR0211072A (pt) 2004-12-14
SI1417180T1 (sl) 2007-04-30
CY1107551T1 (el) 2013-03-13
US20120277432A1 (en) 2012-11-01
US7304156B2 (en) 2007-12-04
US20040176401A1 (en) 2004-09-09
DK1417180T3 (da) 2007-04-10
HUP0401248A2 (hu) 2004-10-28
MXPA04000322A (es) 2005-09-08
EP1417180A4 (en) 2004-10-27
IL159741A (en) 2009-06-15
HUP0401248A3 (en) 2004-11-29
CA2453505A1 (en) 2003-01-23
CO5560574A2 (es) 2005-09-30
CA2453505C (en) 2011-04-19
JP5016583B2 (ja) 2012-09-05
CN100349877C (zh) 2007-11-21
EP1417180A1 (en) 2004-05-12
ATE349431T1 (de) 2007-01-15
AU2002318041B2 (en) 2008-01-03
DE60217126D1 (de) 2007-02-08
ES2278032T3 (es) 2007-08-01
KR20040030051A (ko) 2004-04-08
CN1763016A (zh) 2006-04-26
CN1301977C (zh) 2007-02-28
NZ531033A (en) 2005-07-29
US8614320B2 (en) 2013-12-24
KR100888408B1 (ko) 2009-03-13
PL366831A1 (en) 2005-02-07
EP1417180B1 (en) 2006-12-27
PT1417180E (pt) 2007-03-30
NO326173B1 (no) 2008-10-13
AR082864A2 (es) 2013-01-16
AR034772A1 (es) 2004-03-17
IL159741A0 (en) 2004-06-20
US8222412B2 (en) 2012-07-17
WO2003006439A1 (en) 2003-01-23
JP2004536849A (ja) 2004-12-09
JP4359141B2 (ja) 2009-11-04

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