HK1062438A1 - Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chemosensitizers - Google Patents

Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chemosensitizers

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Publication number
HK1062438A1
HK1062438A1 HK04105049.6A HK04105049A HK1062438A1 HK 1062438 A1 HK1062438 A1 HK 1062438A1 HK 04105049 A HK04105049 A HK 04105049A HK 1062438 A1 HK1062438 A1 HK 1062438A1
Authority
HK
Hong Kong
Prior art keywords
aryl
chemosensitizers
radiosensitizers
chk1 inhibitors
heteroaryl
Prior art date
Application number
HK04105049.6A
Other languages
English (en)
Inventor
Kathleen S Keegan
Edward A Kesicki
John Joseph Gaudino
Adam Wade Cook
Scott Douglas Cowen
Laurence Edward Burgess
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of HK1062438A1 publication Critical patent/HK1062438A1/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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CA2439709A1 (fr) 2002-09-12
ZA200306721B (en) 2004-05-03
KR20080046228A (ko) 2008-05-26
NO326776B1 (no) 2009-02-16
RS52077B (sr) 2012-06-30
HRP20030688A2 (en) 2005-10-31
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EA200300947A1 (ru) 2004-04-29
KR20030078957A (ko) 2003-10-08
EP1379510B1 (fr) 2011-06-01
IS6935A (is) 2003-08-29
SI1379510T1 (sl) 2011-10-28
CA2439709C (fr) 2011-05-03
PT1379510E (pt) 2011-07-15
US20050245525A1 (en) 2005-11-03
HRP20030688B1 (hr) 2013-12-06
CY1111590T1 (el) 2015-10-07
GEP20053659B (en) 2005-11-10
PL364564A1 (en) 2004-12-13
JP4222833B2 (ja) 2009-02-12
US20030069284A1 (en) 2003-04-10
MXPA03007920A (es) 2003-12-04
EA014954B1 (ru) 2011-04-29
IL157563A0 (en) 2004-03-28
US7608618B2 (en) 2009-10-27
UA76977C2 (en) 2006-10-16
BR0207811A (pt) 2005-02-01
ATE511503T1 (de) 2011-06-15
NO20033858L (no) 2003-10-10
KR100861829B1 (ko) 2008-10-07
NO20033858D0 (no) 2003-09-01
ES2365504T3 (es) 2011-10-06
JP2004523568A (ja) 2004-08-05
WO2002070494A1 (fr) 2002-09-12
CN100374425C (zh) 2008-03-12
PL212707B1 (pl) 2012-11-30
US20100105683A1 (en) 2010-04-29
US7067506B2 (en) 2006-06-27
DK1379510T3 (da) 2011-08-29
AU2002258451B2 (en) 2006-08-31
YU69003A (sh) 2006-05-25
CN1507436A (zh) 2004-06-23
EP1379510A1 (fr) 2004-01-14

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