IL157563A0 - Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chemosensitizers - Google Patents

Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chemosensitizers

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Publication number
IL157563A0
IL157563A0 IL15756302A IL15756302A IL157563A0 IL 157563 A0 IL157563 A0 IL 157563A0 IL 15756302 A IL15756302 A IL 15756302A IL 15756302 A IL15756302 A IL 15756302A IL 157563 A0 IL157563 A0 IL 157563A0
Authority
IL
Israel
Prior art keywords
aryl
chemosensitizers
radiosensitizers
chk1 inhibitors
heteroaryl
Prior art date
Application number
IL15756302A
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English (en)
Original Assignee
Icos Corp
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Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of IL157563A0 publication Critical patent/IL157563A0/xx

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

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IL15756302A 2001-03-02 2002-03-01 Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chemosensitizers IL157563A0 (en)

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EA200300947A1 (ru) 2004-04-29
CA2439709A1 (fr) 2002-09-12
UA76977C2 (en) 2006-10-16
ZA200306721B (en) 2004-05-03
ATE511503T1 (de) 2011-06-15
NZ527787A (en) 2005-12-23
PT1379510E (pt) 2011-07-15
PL212707B1 (pl) 2012-11-30
US20050245525A1 (en) 2005-11-03
CN1507436A (zh) 2004-06-23
NO326776B1 (no) 2009-02-16
NO20033858L (no) 2003-10-10
IS6935A (is) 2003-08-29
BR0207811A (pt) 2005-02-01
HRP20030688B1 (hr) 2013-12-06
MXPA03007920A (es) 2003-12-04
WO2002070494A1 (fr) 2002-09-12
CN100374425C (zh) 2008-03-12
EA014954B1 (ru) 2011-04-29
AU2002258451B2 (en) 2006-08-31
US20100105683A1 (en) 2010-04-29
HK1062438A1 (en) 2004-11-05
EP1379510B1 (fr) 2011-06-01
CA2439709C (fr) 2011-05-03
DK1379510T3 (da) 2011-08-29
GEP20053659B (en) 2005-11-10
JP4222833B2 (ja) 2009-02-12
CY1111590T1 (el) 2015-10-07
RS52077B (sr) 2012-06-30
US7067506B2 (en) 2006-06-27
HRP20030688A2 (en) 2005-10-31
KR20030078957A (ko) 2003-10-08
ES2365504T3 (es) 2011-10-06
SI1379510T1 (sl) 2011-10-28
PL364564A1 (en) 2004-12-13
NO20033858D0 (no) 2003-09-01
YU69003A (sh) 2006-05-25
EP1379510A1 (fr) 2004-01-14
KR100861829B1 (ko) 2008-10-07
KR20080046228A (ko) 2008-05-26
US20030069284A1 (en) 2003-04-10
US7608618B2 (en) 2009-10-27

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