HK1059932A1 - Metalloproteinase inhibitors - Google Patents

Metalloproteinase inhibitors

Info

Publication number
HK1059932A1
HK1059932A1 HK04102796A HK04102796A HK1059932A1 HK 1059932 A1 HK1059932 A1 HK 1059932A1 HK 04102796 A HK04102796 A HK 04102796A HK 04102796 A HK04102796 A HK 04102796A HK 1059932 A1 HK1059932 A1 HK 1059932A1
Authority
HK
Hong Kong
Prior art keywords
metalloproteinase inhibitors
metalloproteinase
inhibitors
Prior art date
Application number
HK04102796A
Other languages
English (en)
Inventor
Anders Erikssoen
Matti Lepistoe
Michael Lundkvist
Magnus Munck Af Rosenschold
Pavol Zlatoidsky
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to HK06112181.8A priority Critical patent/HK1091492A1/xx
Publication of HK1059932A1 publication Critical patent/HK1059932A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
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  • Emergency Medicine (AREA)
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HK04102796A 2001-03-15 2004-04-21 Metalloproteinase inhibitors HK1059932A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HK06112181.8A HK1091492A1 (en) 2001-03-15 2004-04-21 Hydantoin derivatives as mmp inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100902A SE0100902D0 (sv) 2001-03-15 2001-03-15 Compounds
PCT/SE2002/000472 WO2002074767A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
HK1059932A1 true HK1059932A1 (en) 2004-07-23

Family

ID=20283374

Family Applications (3)

Application Number Title Priority Date Filing Date
HK04102796A HK1059932A1 (en) 2001-03-15 2004-04-21 Metalloproteinase inhibitors
HK06112181.8A HK1091492A1 (en) 2001-03-15 2004-04-21 Hydantoin derivatives as mmp inhibitors
HK04102888.7A HK1060121A1 (en) 2001-03-15 2004-04-23 Metalloproteinase inhibitors

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK06112181.8A HK1091492A1 (en) 2001-03-15 2004-04-21 Hydantoin derivatives as mmp inhibitors
HK04102888.7A HK1060121A1 (en) 2001-03-15 2004-04-23 Metalloproteinase inhibitors

Country Status (33)

Country Link
US (8) US7368465B2 (pt)
EP (4) EP1370534A1 (pt)
JP (4) JP2004527515A (pt)
KR (4) KR100879905B1 (pt)
CN (5) CN1962641B (pt)
AR (2) AR035695A1 (pt)
AT (3) ATE333454T1 (pt)
AU (2) AU2002237626B2 (pt)
BR (3) BR0207983A (pt)
CA (3) CA2440473C (pt)
CY (1) CY1107525T1 (pt)
CZ (3) CZ20032497A3 (pt)
DE (3) DE60238794D1 (pt)
DK (1) DK1370556T3 (pt)
EE (3) EE05431B1 (pt)
ES (3) ES2357138T3 (pt)
HK (3) HK1059932A1 (pt)
HU (3) HUP0400327A3 (pt)
IL (5) IL157652A0 (pt)
IS (3) IS6943A (pt)
MX (3) MXPA03008191A (pt)
MY (2) MY136141A (pt)
NO (3) NO326087B1 (pt)
NZ (3) NZ528107A (pt)
PL (3) PL364707A1 (pt)
PT (1) PT1370556E (pt)
RU (3) RU2293729C2 (pt)
SE (1) SE0100902D0 (pt)
SI (1) SI1370556T1 (pt)
SK (3) SK287834B6 (pt)
UA (3) UA78502C2 (pt)
WO (3) WO2002074751A1 (pt)
ZA (4) ZA200306731B (pt)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
DE60234028D1 (de) 2001-05-25 2009-11-26 Bristol Myers Squibb Co Hydantion-derivate als hemmer von matrix-metalloproteinasen
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
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ZA200306731B (en) 2004-11-29
PT1370556E (pt) 2006-11-30
UA78502C2 (en) 2007-04-10
CY1107525T1 (el) 2013-03-13
HUP0400202A2 (hu) 2004-08-30
CA2440473A1 (en) 2002-09-26
AR035443A1 (es) 2004-05-26
AR035695A1 (es) 2004-06-23
HUP0400194A3 (en) 2004-10-28
EE200300449A (et) 2003-12-15
HUP0400327A3 (en) 2005-06-28
IL157652A (en) 2010-11-30
CN101602731A (zh) 2009-12-16
WO2002074748A1 (en) 2002-09-26
DE60213216T2 (de) 2007-07-12
US20100273849A1 (en) 2010-10-28
NO20034044D0 (no) 2003-09-12
DE60237965D1 (en) 2010-11-25
ES2352246T3 (es) 2011-02-16
CN1509276A (zh) 2004-06-30
US8153673B2 (en) 2012-04-10
AU2002237626B2 (en) 2007-05-17
IL157656A0 (en) 2004-03-28
IS6942A (is) 2003-09-09
KR100886315B1 (ko) 2009-03-04
NO20034045L (no) 2003-11-10
EP1370537A1 (en) 2003-12-17
KR100879905B1 (ko) 2009-01-21
US7625934B2 (en) 2009-12-01
PL205315B1 (pl) 2010-04-30
RU2003127733A (ru) 2005-03-20
MY136141A (en) 2008-08-29
CN1269804C (zh) 2006-08-16
ZA200306734B (en) 2004-11-29
HUP0400327A2 (hu) 2005-01-28
KR20080071210A (ko) 2008-08-01
BR0207983A (pt) 2004-06-15
CN1962641A (zh) 2007-05-16
EE200300451A (et) 2003-12-15
WO2002074751A1 (en) 2002-09-26
US7427631B2 (en) 2008-09-23
EP1370534A1 (en) 2003-12-17
EP1676846A3 (en) 2006-07-26
KR20030082989A (ko) 2003-10-23
EP1370556B1 (en) 2006-07-19
NZ528140A (en) 2005-02-25
WO2002074748A8 (en) 2004-04-22
HK1091492A1 (en) 2007-01-19
US7754750B2 (en) 2010-07-13
DE60238794D1 (de) 2011-02-10
IS6946A (is) 2003-09-10
SK287766B6 (sk) 2011-09-05
UA77667C2 (en) 2007-01-15
SK10962003A3 (sk) 2004-03-02
CZ20032499A3 (cs) 2004-03-17
CA2440630A1 (en) 2002-09-26
CN1304377C (zh) 2007-03-14
CZ20032497A3 (cs) 2004-02-18
JP2004527515A (ja) 2004-09-09
AU2002237632B2 (en) 2007-05-10
BR0208104A (pt) 2004-03-02
CA2440630C (en) 2011-09-27
CZ20032500A3 (cs) 2004-02-18
CA2440631A1 (en) 2002-09-26
EP1370556A1 (en) 2003-12-17

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