HK1021746A1 - Modulators of tissue regeneration. - Google Patents

Modulators of tissue regeneration.

Info

Publication number
HK1021746A1
HK1021746A1 HK00100386A HK00100386A HK1021746A1 HK 1021746 A1 HK1021746 A1 HK 1021746A1 HK 00100386 A HK00100386 A HK 00100386A HK 00100386 A HK00100386 A HK 00100386A HK 1021746 A1 HK1021746 A1 HK 1021746A1
Authority
HK
Hong Kong
Prior art keywords
modulators
tissue regeneration
purified
new
nucleic acid
Prior art date
Application number
HK00100386A
Other languages
English (en)
Inventor
Michele Sanicola-Nadel
Joseph V Bonventre
Catherine A Hession
Takaharu Ichimura
Henry Wei
Richard L Cate
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26690881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1021746(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of HK1021746A1 publication Critical patent/HK1021746A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Electrotherapy Devices (AREA)
HK00100386A 1996-05-24 2000-01-21 Modulators of tissue regeneration. HK1021746A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1822896P 1996-05-24 1996-05-24
US2344296P 1996-08-23 1996-08-23
PCT/US1997/009303 WO1997044460A1 (en) 1996-05-24 1997-05-23 Modulators of tissue regeneration

Publications (1)

Publication Number Publication Date
HK1021746A1 true HK1021746A1 (en) 2000-06-30

Family

ID=26690881

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00100386A HK1021746A1 (en) 1996-05-24 2000-01-21 Modulators of tissue regeneration.

Country Status (27)

Country Link
US (4) US6664385B1 (de)
EP (2) EP0907735B9 (de)
JP (3) JP4602482B2 (de)
CN (1) CN1147584C (de)
AT (1) ATE318903T1 (de)
AU (1) AU712289B2 (de)
BG (1) BG64678B1 (de)
BR (1) BR9709115A (de)
CA (1) CA2257851C (de)
CZ (1) CZ295936B6 (de)
DE (1) DE69735364T3 (de)
DK (1) DK0907735T5 (de)
EA (1) EA004402B1 (de)
EE (1) EE04817B1 (de)
ES (1) ES2258793T5 (de)
HK (1) HK1021746A1 (de)
HU (1) HU226205B1 (de)
IL (1) IL127162A (de)
IS (1) IS2636B (de)
NO (2) NO327597B1 (de)
NZ (1) NZ336467A (de)
PL (1) PL188826B1 (de)
PT (1) PT907735E (de)
SI (1) SI0907735T2 (de)
SK (1) SK285461B6 (de)
TR (1) TR199802421T2 (de)
WO (1) WO1997044460A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT907735E (pt) * 1996-05-24 2006-06-30 Biogen Idec Inc Moduladores da regeneracao de tecidos
AU7592998A (en) * 1997-05-23 1998-12-11 Biogen, Inc. Modulators of tissue regeneration
ATE526406T1 (de) 1998-03-20 2011-10-15 Commw Scient Ind Res Org Kontrolle der genexpression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1160321A1 (de) * 2000-05-31 2001-12-05 Sanofi-Synthelabo Kidney Injury Novel Gene-1: Isolierung und therapeutische Verwendungen
DE60137934D1 (de) * 2000-06-16 2009-04-23 Biogen Idec Inc Renale regulatorische elemente und deren verwendung
US6812002B2 (en) * 2000-08-30 2004-11-02 Pfizer Inc. Osteoactivin protein and nucleic acids encoding the same, compositions and methods of stimulating bone differentiation
ATE382060T1 (de) * 2001-06-01 2008-01-15 Biogen Idec Inc Moleküle und verfahren zur inhibierung der freisetzung von kim-1
US8709412B2 (en) 2001-06-29 2014-04-29 The Board Of Trustees Of The Leland Stanford Junior University Modulation of TIM receptor activity in combination with cytoreductive therapy
US7553939B2 (en) * 2001-06-29 2009-06-30 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
WO2003080856A2 (en) * 2002-03-19 2003-10-02 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2004060041A2 (en) * 2002-12-30 2004-07-22 Biogen Idec Ma Inc. Kim-1 antagonists and use to modulate immune system
EP1613750B1 (de) * 2003-03-19 2015-10-14 Amgen Fremont Inc. Antikörper gegen das t-zellen-immunglobulindomäne- und mucindomäne-1 (tim-1) antigen und verwendungen davon
DK1616184T4 (en) * 2003-03-27 2018-08-13 Childrens Hospital Med Ct Method and kit for detecting early onset of renal tubular cell damage
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
EP2661963B1 (de) 2004-05-06 2015-09-16 The Trustees of Columbia University in the City of New York Methode für die Diagnose von akutem Nierenversagen oder chronischem Nierenversagen
RU2283666C9 (ru) * 2004-05-14 2007-03-10 Бизяев Алексей Вячеславович Средство для активации восстановления структуры и функции поврежденных тканей и органов
US20060003345A1 (en) * 2004-06-30 2006-01-05 Pfizer Inc RNA bioassay
DK2128625T3 (en) * 2004-12-20 2017-05-01 Antibodyshop As Determination of neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic marker for renal disorders
BRPI0608254A2 (pt) 2005-03-02 2009-12-08 Biogen Idec Inc anticorpos kim-1 para o tratamento de condições mediadas por th2
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
CA2629453C (en) 2005-11-10 2018-03-06 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
EP2035835B1 (de) 2006-05-30 2011-12-28 Antibodyshop A/S Verfahren zur schnellen beurteilung der schwere eines traumas
JP2010500535A (ja) * 2006-08-07 2010-01-07 アンチボディショップ・アクティーゼルスカブ 重大な腎損傷を除外するための診断検査
EP2137538B1 (de) * 2007-03-21 2014-04-09 Bioporto Diagnostics A/s Diagnostischer test auf nierenverletzung
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
US20090297479A1 (en) * 2008-03-28 2009-12-03 Kiyoshi Ariizumi Dc-hil conjugates for treatment of t-cell disorders
EP2324355B1 (de) * 2008-08-28 2014-01-22 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
WO2010025434A1 (en) * 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2767833A3 (de) * 2008-10-21 2014-12-17 Astute Medical, Inc. Verfahren und Zusammensetzungen zur Diagnose und Prognose von Nierenläsion und Niereninsuffizienz
CN103760359B (zh) 2008-10-21 2017-01-11 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
CN102264230B (zh) 2008-11-10 2014-12-10 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
BRPI0921921A2 (pt) * 2008-11-22 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal.
US20100209948A1 (en) * 2009-01-28 2010-08-19 Industrial Technology Research Institute(ITRI) Biomarkers associated with nephropathy
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ598034A (en) 2009-08-07 2014-06-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2010279302B2 (en) * 2009-08-07 2015-06-18 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2010315008B2 (en) 2009-11-07 2015-12-03 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011075744A1 (en) 2009-12-20 2011-06-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
SI2666872T1 (sl) 2010-02-05 2016-08-31 Astute Medical, Inc. Postopki in sestavki za diagnozo in prognozo ledvične poškodbe in odpovedi ledvic
AU2011269847A1 (en) 2010-02-26 2013-01-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2790785A1 (en) 2010-02-26 2011-09-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011149962A1 (en) 2010-05-24 2011-12-01 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
CA2804297A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
DK2672980T3 (en) * 2011-02-09 2018-02-26 Lavivo Ab SYNBIOTIC COMPOSITIONS FOR GETTING UP AND RECONSTITUTING GAS MICROFLORA
WO2013086359A1 (en) 2011-12-08 2013-06-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2925337B1 (de) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutante ngal-proteine und verwendungen davon
ES2681955T3 (es) 2013-01-17 2018-09-17 Astute Medical, Inc. Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue
WO2015134671A1 (en) 2014-03-04 2015-09-11 Targeson, Inc. Molecular imaging contrast agents and uses thereof
WO2017214203A1 (en) 2016-06-06 2017-12-14 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2003A (en) * 1841-03-12 Improvement in horizontal windivhlls
US5019368A (en) * 1989-02-23 1991-05-28 Cancer Biologics, Inc. Detection of necrotic malignant tissue and associated therapy
GB9122820D0 (en) * 1991-10-28 1991-12-11 Wellcome Found Stabilised antibodies
AU4116793A (en) * 1992-04-24 1993-11-29 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
WO1995021922A2 (en) * 1994-02-14 1995-08-17 Abbott Laboratories Non-a, non-b, non-c, non-d, non-e hepatitis reagents and methods for their use
US5622861A (en) * 1994-08-05 1997-04-22 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA encoding hepatitis A virus receptor
CA2196892A1 (en) * 1994-08-18 1996-02-29 The Trustees Of Columbia University Unique associated kaposi's sarcoma virus sequences and uses thereof
US6069230A (en) * 1994-11-10 2000-05-30 Promega Corporation High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
PT907735E (pt) * 1996-05-24 2006-06-30 Biogen Idec Inc Moduladores da regeneracao de tecidos
DE60137934D1 (de) * 2000-06-16 2009-04-23 Biogen Idec Inc Renale regulatorische elemente und deren verwendung
ATE382060T1 (de) * 2001-06-01 2008-01-15 Biogen Idec Inc Moleküle und verfahren zur inhibierung der freisetzung von kim-1
US7553939B2 (en) * 2001-06-29 2009-06-30 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
US7838220B2 (en) * 2001-06-29 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes associated with immune disease
US7215871B2 (en) * 2001-07-27 2007-05-08 Thomson Licensing Changing a playback speed for video presentation recorded in a field structure format
US7687454B2 (en) * 2001-12-03 2010-03-30 The University Of British Columbia Effectors of innate immunity determination
CA2474497C (en) * 2002-01-30 2013-12-03 The Brigham And Women's Hospital, Inc. Compositions and methods related to tim-3, a th1-specific cell surface molecule
WO2003080856A2 (en) * 2002-03-19 2003-10-02 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2004060041A2 (en) * 2002-12-30 2004-07-22 Biogen Idec Ma Inc. Kim-1 antagonists and use to modulate immune system
TW200539890A (en) * 2004-03-12 2005-12-16 Brigham & Womens Hospital Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function
AU2005231685A1 (en) * 2004-03-24 2005-10-20 Telos Pharmaceuticals Llc Compositions as adjuvants to improve immune responses to vaccines and methods of use

Also Published As

Publication number Publication date
BG64678B1 (bg) 2005-11-30
EE9800409A (et) 1999-06-15
US6664385B1 (en) 2003-12-16
EA199801044A1 (ru) 1999-04-29
DK0907735T4 (da) 2009-12-21
ATE318903T1 (de) 2006-03-15
HUP9902770A3 (en) 2001-09-28
JP2001505761A (ja) 2001-05-08
SI0907735T2 (sl) 2010-01-29
EP0907735B1 (de) 2006-03-01
DE69735364D1 (de) 2006-04-27
EA004402B1 (ru) 2004-04-29
IS4902A (is) 1998-11-20
EP0907735B2 (de) 2009-10-07
AU712289B2 (en) 1999-11-04
EP0907735A1 (de) 1999-04-14
CA2257851A1 (en) 1997-11-27
CN1223685A (zh) 1999-07-21
PL188826B1 (pl) 2005-04-29
SK285461B6 (sk) 2007-02-01
DE69735364T3 (de) 2010-05-06
JP2008067701A (ja) 2008-03-27
US20070141590A1 (en) 2007-06-21
PT907735E (pt) 2006-06-30
BG102967A (bg) 2000-05-31
NO985427D0 (no) 1998-11-20
CZ295936B6 (cs) 2005-12-14
WO1997044460A1 (en) 1997-11-27
BR9709115A (pt) 1999-08-03
EE04817B1 (et) 2007-04-16
SI0907735T1 (sl) 2006-08-31
IS2636B (is) 2010-06-15
ES2258793T5 (es) 2010-01-25
DE69735364T2 (de) 2006-11-30
NO327597B1 (no) 2009-08-31
SK160998A3 (en) 1999-07-12
EP1655367A1 (de) 2006-05-10
AU3567697A (en) 1997-12-09
HUP9902770A2 (hu) 1999-12-28
JP2009039111A (ja) 2009-02-26
US20050089868A1 (en) 2005-04-28
JP4602482B2 (ja) 2010-12-22
PL330313A1 (en) 1999-05-10
TR199802421T2 (xx) 1999-02-22
NZ336467A (en) 2000-10-27
CN1147584C (zh) 2004-04-28
DK0907735T5 (da) 2010-06-14
DK0907735T3 (da) 2006-06-26
EP0907735B9 (de) 2010-05-19
JP4316640B2 (ja) 2009-08-19
IL127162A (en) 2007-07-24
US20060286031A1 (en) 2006-12-21
CA2257851C (en) 2011-11-15
CZ381398A3 (cs) 1999-05-12
HU226205B1 (en) 2008-06-30
NO20090945L (no) 1999-01-25
ES2258793T3 (es) 2006-09-01
NO985427L (no) 1999-01-25
IL127162A0 (en) 1999-09-22

Similar Documents

Publication Publication Date Title
HK1021746A1 (en) Modulators of tissue regeneration.
CA2258502A1 (en) Modified factor viii
WO1997026270A3 (en) Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
DE69524365D1 (de) Verfahren zur Isolierung und Reinigung von 2'-Deoxy-2',2'-difluornucleosiden
AU9125198A (en) Compositions, kits, and methods for effecting adenine nucleotide modulation of dna mismatch recognition proteins
WO1998055508A3 (en) HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND DNAs ENCODING THESE PROTEINS
AU2277195A (en) Purified dna polymerase from bacillus stearothermophilus
AU3206095A (en) Neural cell adhesion molecules, nucleotide sequences encoding the molecules, and methods of use thereof
CA2262465A1 (en) Neuritin, a neurogene
WO1997023611A3 (de) Nukleinsäuresequenzen von genen der high mobility group proteine sowie verwendungen derselben
CA2200582A1 (en) Dna encoding human papillomavirus type 6a
ZA9710163B (en) Novel carboxylesterase nucleic acid molecules, proteins and uses thereof.
FI962087A0 (fi) Olefiinien polymerointiin tarkoitettu stereospesifOlefiinien polymerointiin tarkoitettu stereospesifinen katalyyttisysteemi ja monivaiheiset polymeroiinen katalyyttisysteemi ja monivaiheiset polymerointiprosessit, joissa tätä systeemiä käytetään ntiprosessit, joissa tätä systeemiä käytetään
MX9806041A (es) Proteina purificada sr-p70.
AU8811298A (en) Novel peptides and polypeptides useful for regenerating the nervous system
AU3670395A (en) Hippocampus-associated proteins, dna sequences coding therefor and uses thereof
WO1998044134A3 (de) Bakterielle plasmide
DE69840863D1 (de) Verfahren zur Herstellung von 2,6-Diaminopurin-2'deoxyribosid und 2'-Deoxyguanosin
AU6550598A (en) Antithrombin protein and dna sequences
AU4595696A (en) Rna polymerase ii peptides and methods of use
DE69607582D1 (de) Verfahren zur Herstellung und Reinigung von 1,1,1-Tris(4-hydroxyphenyl)ethan
AU4804697A (en) Therapeutic compositions and methods for treating disease states with leukocyte adhesion inhibitor-1 (lai-1), and chemokine beta-11 (ckbeta-11)
AUPN986796A0 (en) Novel nucleic acid molecule and protein
MX9709596A (es) Adn catal ??tico.
HUP9902834A2 (hu) CD44 génkifejezés szabályozása gyógyászati alkalmazásra

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20170522