DE69524365D1 - Verfahren zur Isolierung und Reinigung von 2'-Deoxy-2',2'-difluornucleosiden - Google Patents

Verfahren zur Isolierung und Reinigung von 2'-Deoxy-2',2'-difluornucleosiden

Info

Publication number
DE69524365D1
DE69524365D1 DE69524365T DE69524365T DE69524365D1 DE 69524365 D1 DE69524365 D1 DE 69524365D1 DE 69524365 T DE69524365 T DE 69524365T DE 69524365 T DE69524365 T DE 69524365T DE 69524365 D1 DE69524365 D1 DE 69524365D1
Authority
DE
Germany
Prior art keywords
difluoronucleosides
deoxy
isolation
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69524365T
Other languages
English (en)
Other versions
DE69524365T2 (de
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69524365(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69524365D1 publication Critical patent/DE69524365D1/de
Application granted granted Critical
Publication of DE69524365T2 publication Critical patent/DE69524365T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DE69524365T 1994-11-17 1995-11-09 Verfahren zur Isolierung und Reinigung von 2'-Deoxy-2',2'-difluornucleosiden Expired - Lifetime DE69524365T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (2)

Publication Number Publication Date
DE69524365D1 true DE69524365D1 (de) 2002-01-17
DE69524365T2 DE69524365T2 (de) 2002-08-14

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524365T Expired - Lifetime DE69524365T2 (de) 1994-11-17 1995-11-09 Verfahren zur Isolierung und Reinigung von 2'-Deoxy-2',2'-difluornucleosiden

Country Status (34)

Country Link
US (1) US5606048A (de)
EP (1) EP0712860B1 (de)
JP (1) JPH10509170A (de)
KR (1) KR100424990B1 (de)
CN (1) CN1044119C (de)
AR (1) AR001045A1 (de)
AT (1) ATE210142T1 (de)
AU (1) AU702588B2 (de)
BG (1) BG62737B1 (de)
BR (1) BR9509904A (de)
CA (1) CA2205350C (de)
CO (1) CO4600741A1 (de)
CZ (1) CZ292013B6 (de)
DE (1) DE69524365T2 (de)
DK (1) DK0712860T3 (de)
ES (1) ES2164745T3 (de)
HU (1) HU219019B (de)
IL (1) IL115854A (de)
MX (1) MX9703548A (de)
MY (1) MY115183A (de)
NO (1) NO308305B1 (de)
NZ (1) NZ296712A (de)
PE (1) PE50196A1 (de)
PL (1) PL182052B1 (de)
PT (1) PT712860E (de)
RO (1) RO118296B1 (de)
RU (1) RU2161622C2 (de)
SI (1) SI0712860T1 (de)
SK (1) SK283160B6 (de)
TW (1) TW377356B (de)
UA (1) UA53614C2 (de)
WO (1) WO1996016072A1 (de)
YU (1) YU49446B (de)
ZA (1) ZA959321B (de)

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US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
WO2003059339A1 (en) * 2002-01-15 2003-07-24 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
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BR0312278A (pt) * 2002-06-28 2007-06-19 Idenix Cayman Ltd éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
SI1576138T1 (sl) * 2002-11-15 2017-07-31 Idenix Pharmaceuticals Llc 2'-metil nukleozidi v kombinaciji z interferon in flaviviridae mutacijo
US7598373B2 (en) * 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
EP1912643A2 (de) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurinderivate zur behandlung von infektionen mit flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
WO2006063105A1 (en) * 2004-12-08 2006-06-15 Sicor Inc. Difluoronucleosides and process for preparation thereof
AU2005320374B2 (en) * 2004-12-30 2009-01-08 Hanmi Science Co., Ltd. Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
NZ560735A (en) * 2005-03-04 2009-07-31 Dabur Pharma Ltd Intermediate and process for preparing the beta-anomer of gemcitabine hydrochloride via a low temperature stereoselective glycosylation reaction
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
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KR101171087B1 (ko) * 2005-06-03 2012-08-06 조오지 슐로에머 알파-아노머가 풍부한 2-데옥시-2,2-디플루오로-ｄ-리보푸라노실 설포네이트 및 베타 뉴클레오시드 제조를 위한 이들의 용도
EP1940859A1 (de) * 2005-10-28 2008-07-09 Arch Pharmalabs Limited Verbessertes verfahren zur zubereitung von gemcitabinhydrochlorid
EP1976382B1 (de) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Verfahren zur herstellung eines synthetischen zwischenprodukts für die herstellung von verzweigten nukleosiden
JP2009531284A (ja) * 2006-02-06 2009-09-03 ドクター レディズ ラボラトリーズ リミテッド ゲムシタビンの調製
EP2094651A1 (de) * 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes)
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008117955A1 (en) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
WO2009023845A2 (en) * 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
EP2050757A1 (de) 2007-10-10 2009-04-22 Cilag AG Verfahren zur Herstellung von 2' -deoxy-5-Azacytidin (Decitabin)
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
TWI621624B (zh) * 2008-01-11 2018-04-21 瑞塔醫藥有限責任公司 合成的三萜系化合物及其使用於治療疾病之方法
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
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US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
KR20110010611A (ko) 2008-04-18 2011-02-01 리타 파마슈티컬스 잉크. 산화방지성 염증 조절제 ｃ-17 일치된 올레아놀산 유도체
DK2276493T3 (da) 2008-04-18 2019-01-02 Reata Pharmaceuticals Inc Antioxidative inflammationsmodulatorer: oleanolsyrederivater med amino- og andre modifikationer ved c-17
ES2449396T3 (es) * 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
JO3262B1 (ar) * 2009-04-06 2018-09-16 Otsuka Pharma Co Ltd توليفة من ديسيتابين مع مثبط سيتيدين دي أميناز واستخدامها في علاج السرطان
JP5684787B2 (ja) * 2009-04-06 2015-03-18 大塚製薬株式会社 シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用
WO2010118006A1 (en) * 2009-04-06 2010-10-14 Eisai Inc. (2 ' -deoxy-ribofuranosyl) -1,3,4, 7-tetrahydro- (1,3) iazepin-2-0ne derivatives for treating cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
WO2013151774A1 (en) 2012-04-04 2013-10-10 Halozyme, Inc. Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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Also Published As

Publication number Publication date
SK48597A3 (en) 1997-11-05
MX9703548A (es) 1997-08-30
EP0712860B1 (de) 2001-12-05
KR970707143A (ko) 1997-12-01
US5606048A (en) 1997-02-25
WO1996016072A1 (en) 1996-05-30
BR9509904A (pt) 1997-10-14
ZA959321B (en) 1997-05-05
AR001045A1 (es) 1997-09-24
EP0712860A3 (de) 1996-09-25
TW377356B (en) 1999-12-21
YU49446B (sh) 2006-03-03
ATE210142T1 (de) 2001-12-15
KR100424990B1 (ko) 2004-05-20
NO972214D0 (no) 1997-05-14
PT712860E (pt) 2002-05-31
CN1044119C (zh) 1999-07-14
BG62737B1 (bg) 2000-06-30
CO4600741A1 (es) 1998-05-08
PL320634A1 (en) 1997-10-13
HU219019B (hu) 2001-01-29
CA2205350A1 (en) 1996-05-30
IL115854A (en) 2000-07-16
IL115854A0 (en) 1996-01-31
RU2161622C2 (ru) 2001-01-10
CA2205350C (en) 2007-09-04
ES2164745T3 (es) 2002-03-01
NZ296712A (en) 1999-01-28
CZ148197A3 (en) 1997-08-13
AU702588B2 (en) 1999-02-25
PL182052B1 (pl) 2001-10-31
NO308305B1 (no) 2000-08-28
PE50196A1 (es) 1996-11-30
YU70995A (sh) 1998-09-18
CN1165519A (zh) 1997-11-19
AU4139396A (en) 1996-06-17
EP0712860A2 (de) 1996-05-22
MY115183A (en) 2003-04-30
JPH10509170A (ja) 1998-09-08
DE69524365T2 (de) 2002-08-14
UA53614C2 (uk) 2003-02-17
HUT77926A (hu) 1998-11-30
RO118296B1 (ro) 2003-04-30
NO972214L (no) 1997-05-14
CZ292013B6 (cs) 2003-07-16
DK0712860T3 (da) 2002-03-04
SI0712860T1 (en) 2002-04-30
BG101485A (en) 1998-03-31
SK283160B6 (sk) 2003-03-04

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN