ES2164745T3 - Procedimiento para purificar y aislar 2'-desoxi-2',2'-difluoronucleosidos. - Google Patents

Procedimiento para purificar y aislar 2'-desoxi-2',2'-difluoronucleosidos.

Info

Publication number
ES2164745T3
ES2164745T3 ES95308034T ES95308034T ES2164745T3 ES 2164745 T3 ES2164745 T3 ES 2164745T3 ES 95308034 T ES95308034 T ES 95308034T ES 95308034 T ES95308034 T ES 95308034T ES 2164745 T3 ES2164745 T3 ES 2164745T3
Authority
ES
Spain
Prior art keywords
formula
mixture
anomero
enriquecido
nucleobase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95308034T
Other languages
English (en)
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2164745(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2164745T3 publication Critical patent/ES2164745T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE PRESENTA UN PROCESO PARA PURIFICAR Y AISLAR UN NUCLEOSIDO ENRIQUECIDO CON UN BETA-ANOMERO QUE COMPRENDE A) EL SUMINISTRO DE UNA MEZCLA QUE CONTENGA R" Y UN NUCLEOSIDO ENRIQUECIDO CON BETA-ANOMERO DE LA FORMULA (IB) EN DONDE CADA X SE SELECCIONA INDEPENDIENTEMENTE ENTRE GRUPOS PROTECTORES DE HIDROXIDO Y R'' ES UN NUCLEOBASE DE LA FORMULA EN LA QUE W ES UN GRUPO PROTECTOR DE AMINO, Y R" ES UN NUCLEOBASE DE LA FORMULA EN LA W'' ES UN GRUPO PROTECTOR DE AMINO O HIDROGENO; EN UN SOLVENTE DE ALTO PUNTO DE EBULLICION; B) LA DISOLUCION DE LA MEZCLA CON UN SOLVENTE ORGANICO DEL GRUPO QUE CONSTA DE ETERES, ESTERES Y NITRILOS; C) LA ADICION DE LA MEZCLA DE REACCION DILUIDA A UN ACIDO ACUOSO, Y D) EL MANTENIMIENTO DE LA MEZCLA DE ACIDO ASI PREPARADA A UNA TEMPERATURA DE ENTRE 70 (GRADOS) Y 100 (GRADOS) C HASTA QUE EL PRODUCTO DE LA FORMULA IB, EN EL QUE W ES AHORA W'' SE HAYA PRECIPITADO.
ES95308034T 1994-11-17 1995-11-09 Procedimiento para purificar y aislar 2'-desoxi-2',2'-difluoronucleosidos. Expired - Lifetime ES2164745T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (1)

Publication Number Publication Date
ES2164745T3 true ES2164745T3 (es) 2002-03-01

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95308034T Expired - Lifetime ES2164745T3 (es) 1994-11-17 1995-11-09 Procedimiento para purificar y aislar 2'-desoxi-2',2'-difluoronucleosidos.

Country Status (34)

Country Link
US (1) US5606048A (es)
EP (1) EP0712860B1 (es)
JP (1) JPH10509170A (es)
KR (1) KR100424990B1 (es)
CN (1) CN1044119C (es)
AR (1) AR001045A1 (es)
AT (1) ATE210142T1 (es)
AU (1) AU702588B2 (es)
BG (1) BG62737B1 (es)
BR (1) BR9509904A (es)
CA (1) CA2205350C (es)
CO (1) CO4600741A1 (es)
CZ (1) CZ292013B6 (es)
DE (1) DE69524365T2 (es)
DK (1) DK0712860T3 (es)
ES (1) ES2164745T3 (es)
HU (1) HU219019B (es)
IL (1) IL115854A (es)
MX (1) MX9703548A (es)
MY (1) MY115183A (es)
NO (1) NO308305B1 (es)
NZ (1) NZ296712A (es)
PE (1) PE50196A1 (es)
PL (1) PL182052B1 (es)
PT (1) PT712860E (es)
RO (1) RO118296B1 (es)
RU (1) RU2161622C2 (es)
SI (1) SI0712860T1 (es)
SK (1) SK283160B6 (es)
TW (1) TW377356B (es)
UA (1) UA53614C2 (es)
WO (1) WO1996016072A1 (es)
YU (1) YU49446B (es)
ZA (1) ZA959321B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EA200601591A1 (ru) 2000-05-26 2007-02-27 Айденикс (Кайман) Лимитед Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
EP1465615B1 (en) * 2002-01-15 2012-08-01 Trustees of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
US7456155B2 (en) * 2002-06-28 2008-11-25 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
MXPA05006230A (es) * 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
US20060040944A1 (en) * 2004-06-23 2006-02-23 Gilles Gosselin 5-Aza-7-deazapurine derivatives for treating Flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
JP2007522151A (ja) * 2004-12-08 2007-08-09 シコール インコーポレイティド ジフルオロヌクレオシド及びその調製方法
EP1831236A4 (en) * 2004-12-30 2013-11-20 Hanmi Science Co Ltd PROCESS FOR PREPARING 2'-DEOXY-2 ', 2'-DIFLUOROCYTIDINE
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2006255706B2 (en) * 2005-06-03 2011-06-23 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
US8193354B2 (en) 2005-10-28 2012-06-05 Arch Pharmalabs Limited Process for preparation of Gemcitabine hydrochloride
WO2007075876A2 (en) * 2005-12-23 2007-07-05 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
CA2640463A1 (en) * 2006-02-06 2007-10-18 Dr. Reddy's Laboratories Ltd. Preparation of gemcitabine
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
JP2010510243A (ja) * 2006-11-17 2010-04-02 トラスティーズ オブ ダートマス カレッジ 三環系−ビス−エノン（ｔｂｅ）の合成および生物学的活性
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
EP2139884B1 (en) * 2007-03-23 2013-12-04 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
EP2050757A1 (en) 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
EP3492077A1 (en) * 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8071632B2 (en) * 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
EP2279197B1 (en) * 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
LT2276493T (lt) 2008-04-18 2019-01-10 Reata Pharmaceuticals, Inc. Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17
DK2271658T3 (en) * 2008-04-18 2017-02-06 Reata Pharmaceuticals Inc ANTIOXIDANT INFLAMMATION MODULATORS: C-17 HOMOLOGED OLEANOLIC ACID DERIVATIVES
BRPI0911105B1 (pt) 2008-04-18 2022-11-08 Reata Pharmaceuticals, Inc Compostos contendo um farmacóforo anti-inflamatório, composição farmacêutica, bem como seus usos
AU2009274037B2 (en) * 2008-07-22 2015-07-09 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
TWI477508B (zh) * 2009-04-06 2015-03-21 Otsuka Pharma Co Ltd 用以治療癌症之組成物及方法
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
WO2010118010A1 (en) * 2009-04-06 2010-10-14 Eisai Inc. Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
WO2010118013A1 (en) * 2009-04-06 2010-10-14 Eisai Inc. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
RS57449B1 (sr) 2012-04-04 2018-09-28 Halozyme Inc Kombinovana terapija sa hijaluronidazom i taksanom koji ciljno deluje na tumor
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282921A (en) * 1964-06-04 1966-11-01 Syntex Corp Halo-deoxynucleosides and processes for the preparation thereof
US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
FR2531962B1 (fr) * 1982-08-17 1986-11-14 Sandoz Sa Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
EP0339161A1 (en) * 1988-04-01 1989-11-02 Merrell Dow Pharmaceuticals Inc. Novel fluorophosphonate nucleotide derivatives
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5175267A (en) * 1990-03-02 1992-12-29 University Of Georgia Research Foundation, Inc. Stereoselective glycosylation of hetercyclic bases
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Also Published As

Publication number Publication date
CZ292013B6 (cs) 2003-07-16
BG101485A (en) 1998-03-31
CN1165519A (zh) 1997-11-19
AU702588B2 (en) 1999-02-25
MY115183A (en) 2003-04-30
TW377356B (en) 1999-12-21
CA2205350A1 (en) 1996-05-30
NO308305B1 (no) 2000-08-28
CO4600741A1 (es) 1998-05-08
YU49446B (sh) 2006-03-03
YU70995A (sh) 1998-09-18
PE50196A1 (es) 1996-11-30
EP0712860B1 (en) 2001-12-05
WO1996016072A1 (en) 1996-05-30
SK283160B6 (sk) 2003-03-04
PL320634A1 (en) 1997-10-13
PT712860E (pt) 2002-05-31
EP0712860A3 (en) 1996-09-25
SI0712860T1 (en) 2002-04-30
NZ296712A (en) 1999-01-28
IL115854A0 (en) 1996-01-31
PL182052B1 (pl) 2001-10-31
AR001045A1 (es) 1997-09-24
RO118296B1 (ro) 2003-04-30
ATE210142T1 (de) 2001-12-15
IL115854A (en) 2000-07-16
US5606048A (en) 1997-02-25
AU4139396A (en) 1996-06-17
DE69524365T2 (de) 2002-08-14
SK48597A3 (en) 1997-11-05
UA53614C2 (uk) 2003-02-17
JPH10509170A (ja) 1998-09-08
KR100424990B1 (ko) 2004-05-20
EP0712860A2 (en) 1996-05-22
RU2161622C2 (ru) 2001-01-10
CZ148197A3 (en) 1997-08-13
ZA959321B (en) 1997-05-05
KR970707143A (ko) 1997-12-01
DE69524365D1 (de) 2002-01-17
HUT77926A (hu) 1998-11-30
HU219019B (hu) 2001-01-29
BR9509904A (pt) 1997-10-14
NO972214D0 (no) 1997-05-14
DK0712860T3 (da) 2002-03-04
BG62737B1 (bg) 2000-06-30
NO972214L (no) 1997-05-14
CN1044119C (zh) 1999-07-14
MX9703548A (es) 1997-08-30
CA2205350C (en) 2007-09-04

Similar Documents

Publication Publication Date Title
ES2164745T3 (es) Procedimiento para purificar y aislar 2'-desoxi-2',2'-difluoronucleosidos.
PE51097A1 (es) Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen
ATE13740T1 (de) Peptidester, verfahren zur herstellung derselben und diese enthaltende arzneimittel beziehungsweise diagnostica.
BRPI0518090A (pt) meio de alimentação para um sistema de reação gás/lìquido, método para a reação de um sistema de reação gás-lìquido, equipamento queimador para a reação de um sistema de reação gás-lìquido e método para gaseificar uma corrente de rejeitos lìquidos
DE69015610T2 (de) Verfahren zur Reinigung von verunreinigtem Wasser und Vorrichtung zu dessen Durchführung.
ATE152092T1 (de) Salpetersäureester mit pharmazeutischer wirkung und verfahren zu deren herstellung
ES2127919T3 (es) 4-amino-piridinas, procedimiento para su preparacion, asi como medicamentos que contienen estos compuestos.
BR9807349A (pt) Composto, processos para preparar um composto e para preparar 6-o-alquil eritromicina a.
DE69409828D1 (en) Aromatische polysulfone
JPS5498742A (en) 2-deoxyfortimicin b
AR247403A1 (es) Procedimiento para la preparacion de nuevos acetilen, ciano y alenil derivados de adenosina, utiles como agentes antivirales y antineoplasicos
ES2089402T3 (es) Polimeros que contienen acido fosfinico y su utilizacion en la prevencion de la incrustacion y corrosion.
ES2195143T3 (es) Metodo para la preparacion de melamina.
MY126071A (en) Crystalline form ii of cabergoline.
BR0007941A (pt) Composição para ignição livre de combustìvel produtor de gás, e, processo de geração de gás
ES2145480T3 (es) Amidas de acido carbamoilcarboxilico.
BR0116174A (pt) Processo para resfriar uma mistura de gás quente
ATE104313T1 (de) Neue 9-g(a)-hydroxy-3-oxo-4,24(25)-stigmastadien26-s|urederivate,verfahren zur herstellung und heilmittel daraus.
ATE178603T1 (de) Substituierte heteroarylalkylthiopyridine zur bekämpfung von helicobacter bakterien
ECSP951576A (es) Procedimiento para purificar y aislar 2' -desoxi - 2', difluoronucleosidos
AR241137A2 (es) "procedimiento para preparar beta-metilen-2 o 3-tiofenetanamina".
ES2062135T3 (es) Derivados del acido tienilacetico, procedimiento para su obtencion, su empleo, asi como medicamentos que contienen este y su obtencion.
JPS5466618A (en) Preparation of acrylamide
HUP9904497A2 (hu) Eljárás ivermektin előállítására
ES2128760T3 (es) Nuevos oxidos de fosfanos, procedimiento para su preparacion asi como medicamentos que contienen estos compuestos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 712860

Country of ref document: ES