HUP9904497A2 - Eljárás ivermektin előállítására - Google Patents
Eljárás ivermektin előállításáraInfo
- Publication number
- HUP9904497A2 HUP9904497A2 HU9904497A HUP9904497A HUP9904497A2 HU P9904497 A2 HUP9904497 A2 HU P9904497A2 HU 9904497 A HU9904497 A HU 9904497A HU P9904497 A HUP9904497 A HU P9904497A HU P9904497 A2 HUP9904497 A2 HU P9904497A2
- Authority
- HU
- Hungary
- Prior art keywords
- ivermectin
- sphines
- main
- alkyl group
- production
- Prior art date
Links
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 title abstract 4
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 title abstract 4
- 229960002418 ivermectin Drugs 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000005984 hydrogenation reaction Methods 0.000 abstract 2
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- ZFUKERYTFURFGA-PVVXTEPVSA-N avermectin B1b Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C ZFUKERYTFURFGA-PVVXTEPVSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003283 rhodium Chemical class 0.000 abstract 1
- 150000003284 rhodium compounds Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
A találmány tárgya eljárás ivermektin előállítására, amely abban áll,hőgy az avermektin B1 és B1b keverékét szeletkív hidrőgénezés útjánőlyan katalizátőrők alkalmazásával alakítják ivermektinné, amelyekönmagában ismert módőn ródiűmsókból vagy kőmplex ródiűmvegyületekbőlés főszfinőkból kaphatók, ahől főszfinőkként az (I) általánős képletűkőmplexképző főszfinőkat alkalmazzák. Az (I) képletben R, R' és R''jelentése egymástól függetlenül hidrőgénatőm, alkilcsőpőrt vagy aril-alkil-csőpőrt, A, A' és A'' jelentése egymástól függetlenülkétvegyértékű arőmás csőpőrt, m1, m2 és m3 azőnős vagy eltérő, ésértékük 0 vagy 1, ahől az alkil- és alkőxicsőpőrtőkban tartalmazőttszénatőmők számának összege legalább 12. A hidrőgénezés űtán kapőttreakcióelegyből a katalizátőrrendszert lipőfil őldószerekkel végzettextrakció útján távőlítják el. Így megfelelő minőségű ivermektinhatóanyag nyerhető. (I) ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19644050A DE19644050A1 (de) | 1996-10-31 | 1996-10-31 | Verfahren zur Herstellung von Ivermectin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904497A2 true HUP9904497A2 (hu) | 2000-05-28 |
| HUP9904497A3 HUP9904497A3 (en) | 2000-11-28 |
Family
ID=7809764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904497A HUP9904497A3 (en) | 1996-10-31 | 1997-10-20 | Method for the production of ivermectin |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6072052A (hu) |
| EP (1) | EP0937094B1 (hu) |
| JP (1) | JP2001502716A (hu) |
| KR (1) | KR100468206B1 (hu) |
| CN (1) | CN1146572C (hu) |
| AT (1) | ATE215552T1 (hu) |
| AU (1) | AU5051298A (hu) |
| BR (1) | BR9712690A (hu) |
| CA (1) | CA2269943C (hu) |
| DE (2) | DE19644050A1 (hu) |
| DK (1) | DK0937094T3 (hu) |
| ES (1) | ES2175377T3 (hu) |
| HK (1) | HK1024485A1 (hu) |
| HU (1) | HUP9904497A3 (hu) |
| PT (1) | PT937094E (hu) |
| WO (1) | WO1998018806A1 (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644050A1 (de) * | 1996-10-31 | 1998-05-07 | Bayer Ag | Verfahren zur Herstellung von Ivermectin |
| CN100396691C (zh) * | 2004-12-06 | 2008-06-25 | 四川大学 | 一种伊维菌素的制备方法 |
| CN100486986C (zh) * | 2007-01-29 | 2009-05-13 | 四川大学 | 一种依维菌素的制备方法 |
| PT117268B (pt) | 2021-06-01 | 2023-12-05 | Hovione Farm S A | Processo para controlar o tamanho de partícula e substâncias aparentadas da ivermectina com utilização de alto cisalhamento |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH15982A (en) * | 1977-10-03 | 1983-05-18 | Merck & Co Inc | Selective hydrogenation producta of c-076 compounds and derivatives thereof |
| US4413118A (en) * | 1981-03-02 | 1983-11-01 | Merck & Co., Inc. | Process for removal of homogeneous catalyst group VIII metals from process streams |
| PT74303B (fr) * | 1982-01-19 | 1983-08-08 | Joao Emerico Villax | Procede pour la preparation de nouveaux catalysateurs contenant rhodium et son utilisation |
| US4500458A (en) * | 1982-01-19 | 1985-02-19 | Plurichemie Anstalt | Process for the preparation of α-6-deoxytetracyclines |
| GB2114627B (en) * | 1982-02-09 | 1985-05-01 | Padley And Venables Limited | Mineral mining apparatus provided with dust suppressing means |
| DE19507018A1 (de) * | 1995-03-01 | 1996-09-05 | Bayer Ag | Verfahren zur Herstellung von Ivermectin |
| DE19644050A1 (de) * | 1996-10-31 | 1998-05-07 | Bayer Ag | Verfahren zur Herstellung von Ivermectin |
| IT1289993B1 (it) * | 1997-02-27 | 1998-10-19 | Antibioticos Spa | Processo per la preparazione di ivermectina |
-
1996
- 1996-10-31 DE DE19644050A patent/DE19644050A1/de not_active Withdrawn
-
1997
- 1997-10-20 DE DE59706904T patent/DE59706904D1/de not_active Expired - Fee Related
- 1997-10-20 BR BR9712690-0A patent/BR9712690A/pt not_active IP Right Cessation
- 1997-10-20 ES ES97913164T patent/ES2175377T3/es not_active Expired - Lifetime
- 1997-10-20 AT AT97913164T patent/ATE215552T1/de not_active IP Right Cessation
- 1997-10-20 US US09/297,241 patent/US6072052A/en not_active Expired - Fee Related
- 1997-10-20 JP JP10519998A patent/JP2001502716A/ja not_active Ceased
- 1997-10-20 CN CNB97180494XA patent/CN1146572C/zh not_active Expired - Fee Related
- 1997-10-20 WO PCT/EP1997/005777 patent/WO1998018806A1/de active IP Right Grant
- 1997-10-20 PT PT97913164T patent/PT937094E/pt unknown
- 1997-10-20 KR KR10-1999-7003084A patent/KR100468206B1/ko not_active IP Right Cessation
- 1997-10-20 AU AU50512/98A patent/AU5051298A/en not_active Abandoned
- 1997-10-20 EP EP97913164A patent/EP0937094B1/de not_active Expired - Lifetime
- 1997-10-20 DK DK97913164T patent/DK0937094T3/da active
- 1997-10-20 CA CA002269943A patent/CA2269943C/en not_active Expired - Fee Related
- 1997-10-20 HU HU9904497A patent/HUP9904497A3/hu unknown
-
2000
- 2000-06-27 HK HK00103878A patent/HK1024485A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0937094B1 (de) | 2002-04-03 |
| JP2001502716A (ja) | 2001-02-27 |
| DK0937094T3 (da) | 2002-07-15 |
| KR100468206B1 (ko) | 2005-01-26 |
| BR9712690A (pt) | 1999-10-19 |
| CA2269943A1 (en) | 1998-05-07 |
| WO1998018806A1 (de) | 1998-05-07 |
| CN1146572C (zh) | 2004-04-21 |
| ATE215552T1 (de) | 2002-04-15 |
| CN1239965A (zh) | 1999-12-29 |
| EP0937094A1 (de) | 1999-08-25 |
| DE59706904D1 (de) | 2002-05-08 |
| KR20000049018A (ko) | 2000-07-25 |
| DE19644050A1 (de) | 1998-05-07 |
| ES2175377T3 (es) | 2002-11-16 |
| HUP9904497A3 (en) | 2000-11-28 |
| PT937094E (pt) | 2002-09-30 |
| CA2269943C (en) | 2006-12-12 |
| US6072052A (en) | 2000-06-06 |
| AU5051298A (en) | 1998-05-22 |
| HK1024485A1 (en) | 2000-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Boger et al. | (+)-CC-1065 DNA alkylation: key studies demonstrating a noncovalent binding selectivity contribution to the alkylation selectivity | |
| ATE256143T1 (de) | 2'-0-alkyl-nukleoside und-phosphoramidite, verfahren zu ihrer herstellung und ihre verwendungen | |
| ES542321A0 (es) | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina | |
| WO1996019568A3 (en) | Stabilized ribozyme analogs | |
| CA2212326A1 (en) | O-carbamoyl-(d)-phenylalanilol compounds and process for preparing the same | |
| DE3680800D1 (de) | Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin. | |
| KR870008906A (ko) | 마크로라이드 유도체의 제조방법 | |
| ATE45153T1 (de) | Benzisoselenazolthione, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische produkte. | |
| DE69824843D1 (de) | Verfahren zur herstellung von modifizierten p-chiralen nucleotid-analoga | |
| HUP9904497A2 (hu) | Eljárás ivermektin előállítására | |
| ATE247645T1 (de) | Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung | |
| ATE11134T1 (de) | 1-(3-halogen-2-pyridinyl)piperazine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. | |
| ATE243202T1 (de) | Neue antivirale, homocarbozklische nukleosidderivate von substituierten pyrimidindionen, verfahren zu ihrer herstellung und zusammensetzungen, die diese als aktiven bestandteil enthalten | |
| DK0644196T3 (da) | TTTr som beskyttelsesgruppe i nucleotidsyntesen | |
| ES2097815T3 (es) | Feniletanolaminas, medicamentos que contienen estos compuestos y procedimiento para su preparacion. | |
| Arndt et al. | Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage | |
| DE69621463D1 (de) | Verfahren zum ausgewähltem schutz von baccatinderivaten und ihre verwendung für die synthese von taxanen | |
| BR9908605A (pt) | Kit anticoncepcional, uso de um composto esteróide, e, processo de contracepção | |
| JP2021080214A (ja) | ビオチンの製造方法 | |
| SU1573021A1 (ru) | 14 @ -Окси-7,8-метилендиоксиаллобербан, обладающий антидепрессивной активностью | |
| ATE83241T1 (de) | 16,17-acetal-substituierte androstane-17-betacarbons|ureester, verfahren zu deren herstellung und pharmazeutische praeparate die diese enthalten. | |
| JPS5695173A (en) | Preparation of 5-fluorocytosine | |
| ATE56451T1 (de) | Verfahren zur herstellung von oxabicycloalkanverbindungen. | |
| Allart et al. | 1, 5-Anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA | |
| ATE18223T1 (de) | Ergolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |