CO4600741A1 - Procedimiento para purificar y aislar 2´-desoxi-2´,2´-di- fluoronucleosidos - Google Patents

Procedimiento para purificar y aislar 2´-desoxi-2´,2´-di- fluoronucleosidos

Info

Publication number
CO4600741A1
CO4600741A1 CO95053588A CO95053588A CO4600741A1 CO 4600741 A1 CO4600741 A1 CO 4600741A1 CO 95053588 A CO95053588 A CO 95053588A CO 95053588 A CO95053588 A CO 95053588A CO 4600741 A1 CO4600741 A1 CO 4600741A1
Authority
CO
Colombia
Prior art keywords
formula
mixture
procedure
nucleoside
enriched
Prior art date
Application number
CO95053588A
Other languages
English (en)
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO4600741(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4600741A1 publication Critical patent/CO4600741A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

REIVINDICACION NUMERO UN PROCEDIMIENTO PARA PURIFICAR Y AISLAR UN NU- CLEOSIDO ENRIQUECIDO EN EL ANOMERO BETA QUE COM- PRENDE a) PROPORCIONAR UNA MEZCLA QUE CONTIENE R" Y UN NUCLEOSIDO ENRIQUECIDO EN EL ANOMERO BETA, DE LA FORMULA FIGURA 1 EN LA QUE X SE SELECCIONA INDEPENDIENTEMENTE ENTRE GRUPOS PROTECTORES DE HIDROXI Y R´ ES UN NUCLEOBA- SE DE LA FORMULA FIGURA 2 EN LA QUE W ES UN GRUPO PROTECTOR DE AMINO; Y R" ES UN NUCLEOBASE DE LA FORMULA FIGURA 3 EN LA QUE W´ ES UN GRUPO PROTECTOR DE AMINO O HI- DROGENO; EN UN DISOLVENTE DE ALTA EBULLICION; b) DILUIR LA MEZCLA CON UN DISOLVENTE ORGANICO SE- LECCIONADO ENTRE EL GRUPO COMPUESTO POR ESTERES, ESTERES Y NITRILOS; c) ANADIR LA MEZCLA DE REACCION DILUIDA EN ACIDO ACUOSO; Y d) MANTENER LA MEZCLA ACIDA ASI PREPARADA A UNA TEMPERATURA DE 22 GRADOS CENTIGRADOS A 100 GRADOS CENTIGRADOS HASTA QUE HAYA PRECIPITADO EL PRODUCTO DE FORMULA IB, EN EL QUE W ES AHORA W´ ".
CO95053588A 1994-11-17 1995-11-14 Procedimiento para purificar y aislar 2´-desoxi-2´,2´-di- fluoronucleosidos CO4600741A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (1)

Publication Number Publication Date
CO4600741A1 true CO4600741A1 (es) 1998-05-08

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95053588A CO4600741A1 (es) 1994-11-17 1995-11-14 Procedimiento para purificar y aislar 2´-desoxi-2´,2´-di- fluoronucleosidos

Country Status (34)

Country Link
US (1) US5606048A (es)
EP (1) EP0712860B1 (es)
JP (1) JPH10509170A (es)
KR (1) KR100424990B1 (es)
CN (1) CN1044119C (es)
AR (1) AR001045A1 (es)
AT (1) ATE210142T1 (es)
AU (1) AU702588B2 (es)
BG (1) BG62737B1 (es)
BR (1) BR9509904A (es)
CA (1) CA2205350C (es)
CO (1) CO4600741A1 (es)
CZ (1) CZ292013B6 (es)
DE (1) DE69524365T2 (es)
DK (1) DK0712860T3 (es)
ES (1) ES2164745T3 (es)
HU (1) HU219019B (es)
IL (1) IL115854A (es)
MX (1) MX9703548A (es)
MY (1) MY115183A (es)
NO (1) NO308305B1 (es)
NZ (1) NZ296712A (es)
PE (1) PE50196A1 (es)
PL (1) PL182052B1 (es)
PT (1) PT712860E (es)
RO (1) RO118296B1 (es)
RU (1) RU2161622C2 (es)
SI (1) SI0712860T1 (es)
SK (1) SK283160B6 (es)
TW (1) TW377356B (es)
UA (1) UA53614C2 (es)
WO (1) WO1996016072A1 (es)
YU (1) YU49446B (es)
ZA (1) ZA959321B (es)

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Also Published As

Publication number Publication date
NZ296712A (en) 1999-01-28
EP0712860B1 (en) 2001-12-05
AU4139396A (en) 1996-06-17
PL182052B1 (pl) 2001-10-31
AU702588B2 (en) 1999-02-25
UA53614C2 (uk) 2003-02-17
ZA959321B (en) 1997-05-05
ATE210142T1 (de) 2001-12-15
EP0712860A3 (en) 1996-09-25
CZ148197A3 (en) 1997-08-13
DE69524365T2 (de) 2002-08-14
SK283160B6 (sk) 2003-03-04
HUT77926A (hu) 1998-11-30
NO972214D0 (no) 1997-05-14
US5606048A (en) 1997-02-25
BG101485A (en) 1998-03-31
TW377356B (en) 1999-12-21
CN1165519A (zh) 1997-11-19
NO972214L (no) 1997-05-14
CA2205350C (en) 2007-09-04
WO1996016072A1 (en) 1996-05-30
HU219019B (hu) 2001-01-29
DK0712860T3 (da) 2002-03-04
BR9509904A (pt) 1997-10-14
YU49446B (sh) 2006-03-03
NO308305B1 (no) 2000-08-28
MY115183A (en) 2003-04-30
YU70995A (sh) 1998-09-18
PL320634A1 (en) 1997-10-13
CA2205350A1 (en) 1996-05-30
CZ292013B6 (cs) 2003-07-16
KR100424990B1 (ko) 2004-05-20
IL115854A0 (en) 1996-01-31
SI0712860T1 (en) 2002-04-30
RO118296B1 (ro) 2003-04-30
IL115854A (en) 2000-07-16
CN1044119C (zh) 1999-07-14
RU2161622C2 (ru) 2001-01-10
KR970707143A (ko) 1997-12-01
ES2164745T3 (es) 2002-03-01
SK48597A3 (en) 1997-11-05
JPH10509170A (ja) 1998-09-08
DE69524365D1 (de) 2002-01-17
PE50196A1 (es) 1996-11-30
PT712860E (pt) 2002-05-31
MX9703548A (es) 1997-08-30
EP0712860A2 (en) 1996-05-22
BG62737B1 (bg) 2000-06-30
AR001045A1 (es) 1997-09-24

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