HUP9902834A2 - CD44 génkifejezés szabályozása gyógyászati alkalmazásra - Google Patents
CD44 génkifejezés szabályozása gyógyászati alkalmazásraInfo
- Publication number
- HUP9902834A2 HUP9902834A2 HU9902834A HUP9902834A HUP9902834A2 HU P9902834 A2 HUP9902834 A2 HU P9902834A2 HU 9902834 A HU9902834 A HU 9902834A HU P9902834 A HUP9902834 A HU P9902834A HU P9902834 A2 HUP9902834 A2 HU P9902834A2
- Authority
- HU
- Hungary
- Prior art keywords
- icn
- control
- gene expression
- therapeutic use
- icn248
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 102100032912 CD44 antigen Human genes 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
CD-44-et túlzőtt mértékben kifejező ráksejteket, különösen nem-kissejtes tüdőrák- és melanómiasejteket kezelnek antiszensz őligőnűk-leőtidőkkal, hőgy a C44 kifejezését kőrlátőzzák. A vizsgált eredményekazt műtatják, hőgy az őltalmazni kívánt őligőnűkleőtidők jelentősencsökkentik a sejtnövekedést és tüdőrák- és melanómiasejtek esetében,CD44-re fajlagős módőn, űgyanakkőr nem tőxikűsak a nőrmális sej-tekre. ŕ
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9902834A HUP9902834A3 (en) | 1996-07-31 | 1996-07-31 | Control of cd44 gene expression for therapeutic use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9902834A HUP9902834A3 (en) | 1996-07-31 | 1996-07-31 | Control of cd44 gene expression for therapeutic use |
PCT/US1996/012598 WO1997006827A1 (en) | 1995-08-14 | 1996-07-31 | Control of cd44 gene expression for therapeutic use |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9902834A2 true HUP9902834A2 (hu) | 1999-12-28 |
HUP9902834A3 HUP9902834A3 (en) | 2001-04-28 |
Family
ID=89999088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9902834A HUP9902834A3 (en) | 1996-07-31 | 1996-07-31 | Control of cd44 gene expression for therapeutic use |
Country Status (1)
Country | Link |
---|---|
HU (1) | HUP9902834A3 (hu) |
-
1996
- 1996-07-31 HU HU9902834A patent/HUP9902834A3/hu unknown
Also Published As
Publication number | Publication date |
---|---|
HUP9902834A3 (en) | 2001-04-28 |
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