GB1526331A - Phthalanes - Google Patents

Phthalanes

Info

Publication number
GB1526331A
GB1526331A GB1486/76A GB148676A GB1526331A GB 1526331 A GB1526331 A GB 1526331A GB 1486/76 A GB1486/76 A GB 1486/76A GB 148676 A GB148676 A GB 148676A GB 1526331 A GB1526331 A GB 1526331A
Authority
GB
United Kingdom
Prior art keywords
jan
phthalanes
kefalas
alkanoyl
heading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1486/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Kefalas AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9722860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1526331(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GB1486/76A priority Critical patent/GB1526331A/en
Application filed by Kefalas AS filed Critical Kefalas AS
Priority to DE2657013A priority patent/DE2657013C2/de
Priority to SE7614201A priority patent/SE429551B/xx
Priority to AT947276A priority patent/AT359488B/de
Priority to IE5/77A priority patent/IE44055B1/en
Priority to ZA770057A priority patent/ZA7757B/xx
Priority to AU21073/77A priority patent/AU509445B2/en
Priority to NZ183001A priority patent/NZ183001A/en
Priority to US05/757,619 priority patent/US4136193A/en
Priority to FI770073A priority patent/FI63754C/fi
Priority to ES454980A priority patent/ES454980A1/es
Priority to NL7700244A priority patent/NL192451C/nl
Priority to NO770109A priority patent/NO147243C/no
Priority to CA000269610A priority patent/CA1094087A/en
Priority to CH42377A priority patent/CH626886A5/de
Priority to JP199777A priority patent/JPS52105162A/ja
Priority to BE174098A priority patent/BE850401A/xx
Priority to DK13177A priority patent/DK143275C/da
Priority to FR7701079A priority patent/FR2338271A1/fr
Publication of GB1526331A publication Critical patent/GB1526331A/en
Priority to AT571979A priority patent/AT360001B/de
Priority to AT572079A priority patent/AT360002B/de
Priority to CH357481A priority patent/CH632258A5/de
Priority to CH357581A priority patent/CH632259A5/de
Priority to NO1996001C priority patent/NO1996001I1/no
Priority to NL970031C priority patent/NL970031I2/nl
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB1486/76A 1976-01-14 1976-01-14 Phthalanes Expired GB1526331A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes
DE2657013A DE2657013C2 (de) 1976-01-14 1976-12-16 1-(3-Dimethylaminopropyl)-phthalane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE7614201A SE429551B (sv) 1976-01-14 1976-12-17 Sett att framstella 1-(3-dimetylamino-propyl)-ftalanderivat
AT947276A AT359488B (de) 1976-01-14 1976-12-21 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch annehm- baren saeureadditionssalzen
IE5/77A IE44055B1 (en) 1976-01-14 1977-01-04 Phthalanes
ZA770057A ZA7757B (en) 1976-01-14 1977-01-05 Organic compounds
AU21073/77A AU509445B2 (en) 1976-01-14 1977-01-05 Phathalanes
NZ183001A NZ183001A (en) 1976-01-14 1977-01-06 3-dimethylamin opropyl-3-phenyl-benzo(c)furans,and pharmaceutical compositions
US05/757,619 US4136193A (en) 1976-01-14 1977-01-07 Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
FI770073A FI63754C (fi) 1976-01-14 1977-01-11 Foerfarande foer framstaellning av en terapeutiskt anvaendbar ftalan
ES454980A ES454980A1 (es) 1976-01-14 1977-01-12 Metodo para preparar un ftalano.
NL7700244A NL192451C (nl) 1976-01-14 1977-01-12 Werkwijze voor de bereiding van ftalanderivaten en werkwijze voor de bereiding van farmaceutische preparaten die een ftalanderivaat bevatten.
CH42377A CH626886A5 (enExample) 1976-01-14 1977-01-13
NO770109A NO147243C (no) 1976-01-14 1977-01-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive ftalanderivater
JP199777A JPS52105162A (en) 1976-01-14 1977-01-13 Phthleic derivatives and preparation thereof
CA000269610A CA1094087A (en) 1976-01-14 1977-01-13 Phthalane derivatives, compositions thereof and a method of preparation thereof
BE174098A BE850401A (fr) 1976-01-14 1977-01-14 Derives de phtalane et procede de preparation
DK13177A DK143275C (da) 1976-01-14 1977-01-14 Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
FR7701079A FR2338271A1 (fr) 1976-01-14 1977-01-14 Derives du phtalane, procede pour leur preparation, et compositions pharmaceutiques contenant de tels derives
AT572079A AT360002B (de) 1976-01-14 1979-08-27 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch ver- traeglichen saeureadditionssalzen
AT571979A AT360001B (de) 1976-01-14 1979-08-27 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch ver- traeglichen saeureadditionssalzen
CH357581A CH632259A5 (de) 1976-01-14 1981-06-01 Verfahren zur herstellung von neuen phthalanen.
CH357481A CH632258A5 (de) 1976-01-14 1981-06-01 Verfahren zur herstellung von neuen phthalanen.
NO1996001C NO1996001I1 (no) 1976-01-14 1996-01-05 Citalopram
NL970031C NL970031I2 (nl) 1976-01-14 1997-08-04 Werkwijze voor de bereiding van ftalanderivaten enwerkwijze voor de bereiding van farmaceutische pr eparaten die een ftalanderivaat bevatten.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Publications (1)

Publication Number Publication Date
GB1526331A true GB1526331A (en) 1978-09-27

Family

ID=9722860

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1486/76A Expired GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Country Status (19)

Country Link
US (1) US4136193A (enExample)
JP (1) JPS52105162A (enExample)
AT (1) AT359488B (enExample)
AU (1) AU509445B2 (enExample)
BE (1) BE850401A (enExample)
CA (1) CA1094087A (enExample)
CH (3) CH626886A5 (enExample)
DE (1) DE2657013C2 (enExample)
DK (1) DK143275C (enExample)
ES (1) ES454980A1 (enExample)
FI (1) FI63754C (enExample)
FR (1) FR2338271A1 (enExample)
GB (1) GB1526331A (enExample)
IE (1) IE44055B1 (enExample)
NL (2) NL192451C (enExample)
NO (2) NO147243C (enExample)
NZ (1) NZ183001A (enExample)
SE (1) SE429551B (enExample)
ZA (1) ZA7757B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
WO2001002383A3 (en) * 1999-07-06 2001-05-03 Vis Farmaceutici S P A Process for the synthesis of citalopram
WO2002070501A1 (en) * 2001-03-07 2002-09-12 Cipla Ltd. Preparation of phthalanes
EP1265883A1 (en) 2000-03-13 2002-12-18 H. Lundbeck A/S Method for the preparation of citalopram
WO2003072563A1 (en) * 2002-02-27 2003-09-04 Cipla Ltd. Amorphous citalopram salts
US7002025B2 (en) 2000-03-07 2006-02-21 Resolution Chemicals Limited Process for the preparation of citalopram

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
ATE192042T1 (de) * 1995-08-16 2000-05-15 Lilly Co Eli Potenzierung von serotonin-wirkstoffresponz
EA001728B1 (ru) * 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) * 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
HRP20010418A2 (en) 1998-12-08 2002-06-30 Lundbeck & Co As H Benzofuran derivatives, their preparation and use
AR021509A1 (es) * 1998-12-08 2002-07-24 Lundbeck & Co As H Derivados de benzofurano, su preparacion y uso
ATE236145T1 (de) 1998-12-23 2003-04-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
JP3798940B2 (ja) * 1999-04-14 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
SK287140B6 (sk) 1999-10-25 2010-01-07 H. Lundbeck A/S Spôsob prípravy citalopramu a medziprodukt na jeho výrobu
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
PL198803B1 (pl) * 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
KR100660802B1 (ko) * 2000-01-14 2006-12-26 하. 룬트벡 아크티에 셀스카브 5-시아노프탈리드의 제조 방법
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) * 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
TR200202195T2 (tr) * 2000-03-13 2002-12-23 H. Lundbeck A/S 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
ES2214400T3 (es) 2000-03-14 2004-09-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AU2001257022B2 (en) * 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
KR100821912B1 (ko) * 2000-05-12 2008-04-16 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
WO2002004435A1 (en) * 2000-07-06 2002-01-17 H. Lundbeck A/S Method for the preparation of citalopram
AU8174001A (en) * 2000-07-21 2002-02-05 Lundbeck & Co As H Novel compounds and their use as glycine transport inhibitors
IS6021A (is) * 2000-08-10 2001-10-20 H. Lundbeck A/S Lyfjasamsetningar sem innihalda sítalópram
IL144816A (en) * 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
HK1048812B (zh) * 2000-12-22 2007-06-01 H‧隆德贝克有限公司 制备纯西酞普兰的方法
EA003459B1 (ru) * 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
DE10112828C1 (de) * 2000-12-28 2002-11-21 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
DE10164725B4 (de) * 2000-12-28 2004-08-26 H. Lundbeck A/S Verfahren zur Herstellung von gereinigtem Citalopram
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
CA2435925A1 (en) * 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
JP2004529883A (ja) * 2001-02-22 2004-09-30 ナトコ ファーマ リミテッド シタロプラムの調製方法
PL372133A1 (en) * 2001-03-09 2005-07-11 Ranbaxy Laboratories Limited Process for the preparation of citalopram
US20040198809A1 (en) * 2001-05-01 2004-10-07 Connie Sanchez Use of enantiomeric pure escitalopram
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IN192057B (enExample) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
DK1522539T3 (da) * 2001-07-31 2007-05-07 Lundbeck & Co As H Krystallinsk komposition indeholdende excitalopram
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
CN1606554B (zh) * 2001-10-12 2013-03-20 阿泽范药品公司 β-内酰胺后叶加压素V1a拮抗剂
IN192863B (enExample) * 2001-11-13 2004-05-22 Ranbaxy Lab Ltd
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
CN100402489C (zh) * 2002-03-27 2008-07-16 坂东化学株式会社 新型1,3,5-三(芳氨基)苯类
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
EA013116B1 (ru) * 2002-12-23 2010-02-26 Х. Лундбекк А/С Эсциталопрамгидробромид, его применение и фармкомпозиция
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WO2005042473A1 (en) * 2003-10-28 2005-05-12 Wockhardt Limited Improved process for the manufacture of citalopram hydrobromide
ES2240931T3 (es) * 2003-10-28 2005-10-16 Adorkem Technology Spa Procedimiento para la preparacion de citalopram.
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ES454980A1 (es) 1978-04-01
IE44055B1 (en) 1981-07-29
JPS52105162A (en) 1977-09-03
FI63754C (fi) 1983-08-10
NO147243C (no) 1983-03-02
SE429551B (sv) 1983-09-12
ZA7757B (en) 1977-11-30
FI63754B (fi) 1983-04-29
DE2657013C2 (de) 1985-11-14
NZ183001A (en) 1978-06-02
JPS6135986B2 (enExample) 1986-08-15
IE44055L (en) 1977-07-14
NO1996001I1 (no) 1996-01-05
FI770073A7 (enExample) 1977-07-15
NL192451B (nl) 1997-04-01
NL970031I1 (nl) 1997-10-01
NO147243B (no) 1982-11-22
CA1094087A (en) 1981-01-20
DK143275C (da) 1982-01-18
FR2338271B1 (enExample) 1982-11-05
DE2657013A1 (de) 1977-07-28
CH632259A5 (de) 1982-09-30
FR2338271A1 (fr) 1977-08-12
US4136193A (en) 1979-01-23
AU509445B2 (en) 1980-05-15
BE850401A (fr) 1977-07-14
AU2107377A (en) 1978-07-13
SE7614201L (sv) 1977-07-15
NO770109L (no) 1977-07-15
AT359488B (de) 1980-11-10
DK13177A (da) 1977-07-15
NL7700244A (nl) 1977-07-18
DK143275B (da) 1981-08-03
ATA947276A (de) 1980-04-15
NL192451C (nl) 1997-08-04
CH626886A5 (enExample) 1981-12-15
CH632258A5 (de) 1982-09-30
NL970031I2 (nl) 1997-10-01

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