JPS52105162A - Phthleic derivatives and preparation thereof - Google Patents

Phthleic derivatives and preparation thereof

Info

Publication number
JPS52105162A
JPS52105162A JP199777A JP199777A JPS52105162A JP S52105162 A JPS52105162 A JP S52105162A JP 199777 A JP199777 A JP 199777A JP 199777 A JP199777 A JP 199777A JP S52105162 A JPS52105162 A JP S52105162A
Authority
JP
Japan
Prior art keywords
phthleic
derivatives
preparation
phthleic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP199777A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6135986B2 (enExample
Inventor
Peetaa Baagesa Kurausu
Sutausubaaru Tofuto Andaasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Kefalas AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9722860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS52105162(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kefalas AS filed Critical Kefalas AS
Publication of JPS52105162A publication Critical patent/JPS52105162A/ja
Publication of JPS6135986B2 publication Critical patent/JPS6135986B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP199777A 1976-01-14 1977-01-13 Phthleic derivatives and preparation thereof Granted JPS52105162A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Publications (2)

Publication Number Publication Date
JPS52105162A true JPS52105162A (en) 1977-09-03
JPS6135986B2 JPS6135986B2 (enExample) 1986-08-15

Family

ID=9722860

Family Applications (1)

Application Number Title Priority Date Filing Date
JP199777A Granted JPS52105162A (en) 1976-01-14 1977-01-13 Phthleic derivatives and preparation thereof

Country Status (19)

Country Link
US (1) US4136193A (enExample)
JP (1) JPS52105162A (enExample)
AT (1) AT359488B (enExample)
AU (1) AU509445B2 (enExample)
BE (1) BE850401A (enExample)
CA (1) CA1094087A (enExample)
CH (3) CH626886A5 (enExample)
DE (1) DE2657013C2 (enExample)
DK (1) DK143275C (enExample)
ES (1) ES454980A1 (enExample)
FI (1) FI63754C (enExample)
FR (1) FR2338271A1 (enExample)
GB (1) GB1526331A (enExample)
IE (1) IE44055B1 (enExample)
NL (2) NL192451C (enExample)
NO (2) NO147243C (enExample)
NZ (1) NZ183001A (enExample)
SE (1) SE429551B (enExample)
ZA (1) ZA7757B (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0236177A (ja) * 1988-06-14 1990-02-06 H Lundbeck As 新規鏡像体及びその単離法
JP2002531556A (ja) * 1998-12-08 2002-09-24 ハー・ルンドベック・アクチエゼルスカベット ベンゾフラン誘導体、その製造方法及びその使用方法
JP2005535322A (ja) * 2002-08-12 2005-11-24 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムの製造に使用することができる中間体の分離方法
JP2006520351A (ja) * 2003-03-13 2006-09-07 エイドルケム テクノロジー エスピーエー シアノイソベンゾフランの製造方法
JP2007511477A (ja) * 2003-10-28 2007-05-10 エイドルケム テクノロジー エスピーエー シタロプラムの製造方法
JP2008105270A (ja) * 2006-10-25 2008-05-08 Shisuko:Kk 無湿乾燥用ホッパー装置
JP2011502981A (ja) * 2007-11-02 2011-01-27 ドン・ア・ファーム・カンパニー・リミテッド 新規な１，３−ジヒドロ−５−イソベンゾフランカルボニトリル誘導体およびそれを含む早漏症治療用医薬組成物

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
PT759299E (pt) * 1995-08-16 2000-09-29 Lilly Co Eli Potenciacao da resposta de serotonina
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CN1286687A (zh) * 1997-11-11 2001-03-07 H·隆德贝克有限公司 制备西酞普兰的方法
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
HRP20010418A2 (en) 1998-12-08 2002-06-30 Lundbeck & Co As H Benzofuran derivatives, their preparation and use
HK1043130B (zh) 1998-12-23 2005-03-04 H‧隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
HK1043129B (zh) 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
PT1246813E (pt) * 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
WO2001051477A1 (en) * 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) * 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
BR0109364A (pt) * 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
SK14602002A3 (sk) 2000-03-13 2003-02-04 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
TR200202168T2 (tr) * 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
KR100821912B1 (ko) * 2000-05-12 2008-04-16 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
SK3362002A3 (en) * 2000-07-06 2002-08-06 Lundbeck & Co As H Method for the preparation of citalopram
HUP0302778A3 (en) * 2000-07-21 2005-02-28 Lundbeck & Co As H Novel compounds and their use as glycine transport inhibitors
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IL144816A (en) * 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
TR200201166T1 (tr) * 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
DE10164725B4 (de) * 2000-12-28 2004-08-26 H. Lundbeck A/S Verfahren zur Herstellung von gereinigtem Citalopram
JP2003519121A (ja) * 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
DE10112828C1 (de) * 2000-12-28 2002-11-21 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
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WO2002066453A1 (en) * 2001-02-22 2002-08-29 Natco Pharma Limited Process for the preparation of citalopram
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
HRP20030811A2 (en) * 2001-03-09 2005-08-31 Ranbaxy Laboratories Limited Process for the preparation of citalopram
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EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
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Cited By (8)

* Cited by examiner, † Cited by third party
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JPH0236177A (ja) * 1988-06-14 1990-02-06 H Lundbeck As 新規鏡像体及びその単離法
JP2002531556A (ja) * 1998-12-08 2002-09-24 ハー・ルンドベック・アクチエゼルスカベット ベンゾフラン誘導体、その製造方法及びその使用方法
JP2005535322A (ja) * 2002-08-12 2005-11-24 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムの製造に使用することができる中間体の分離方法
JP2011055842A (ja) * 2002-08-12 2011-03-24 H Lundbeck As エスシタロプラムの製造に使用することができる中間体の分離方法
JP2006520351A (ja) * 2003-03-13 2006-09-07 エイドルケム テクノロジー エスピーエー シアノイソベンゾフランの製造方法
JP2007511477A (ja) * 2003-10-28 2007-05-10 エイドルケム テクノロジー エスピーエー シタロプラムの製造方法
JP2008105270A (ja) * 2006-10-25 2008-05-08 Shisuko:Kk 無湿乾燥用ホッパー装置
JP2011502981A (ja) * 2007-11-02 2011-01-27 ドン・ア・ファーム・カンパニー・リミテッド 新規な１，３−ジヒドロ−５−イソベンゾフランカルボニトリル誘導体およびそれを含む早漏症治療用医薬組成物

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SE7614201L (sv) 1977-07-15
CH632259A5 (de) 1982-09-30
DK13177A (da) 1977-07-15
AU2107377A (en) 1978-07-13
NL192451B (nl) 1997-04-01
NL970031I1 (nl) 1997-10-01
FR2338271B1 (enExample) 1982-11-05
CH632258A5 (de) 1982-09-30
SE429551B (sv) 1983-09-12
DE2657013A1 (de) 1977-07-28
IE44055B1 (en) 1981-07-29
NO147243C (no) 1983-03-02
FI63754B (fi) 1983-04-29
GB1526331A (en) 1978-09-27
US4136193A (en) 1979-01-23
CH626886A5 (enExample) 1981-12-15
FI770073A7 (enExample) 1977-07-15
AU509445B2 (en) 1980-05-15
NL192451C (nl) 1997-08-04
JPS6135986B2 (enExample) 1986-08-15
NL970031I2 (nl) 1997-10-01
NL7700244A (nl) 1977-07-18
NO147243B (no) 1982-11-22
IE44055L (en) 1977-07-14
FR2338271A1 (fr) 1977-08-12
DK143275B (da) 1981-08-03
FI63754C (fi) 1983-08-10
NZ183001A (en) 1978-06-02
ATA947276A (de) 1980-04-15
DE2657013C2 (de) 1985-11-14
CA1094087A (en) 1981-01-20
NO770109L (no) 1977-07-15
AT359488B (de) 1980-11-10
ZA7757B (en) 1977-11-30
BE850401A (fr) 1977-07-14
ES454980A1 (es) 1978-04-01
NO1996001I1 (no) 1996-01-05
DK143275C (da) 1982-01-18

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