GB0004887D0 - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
GB0004887D0
GB0004887D0 GBGB0004887.6A GB0004887A GB0004887D0 GB 0004887 D0 GB0004887 D0 GB 0004887D0 GB 0004887 A GB0004887 A GB 0004887A GB 0004887 D0 GB0004887 D0 GB 0004887D0
Authority
GB
United Kingdom
Prior art keywords
sub
sup
chemical compounds
kinase
fak
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0004887.6A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9886703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB0004887(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Priority to GBGB0004887.6A priority Critical patent/GB0004887D0/en
Publication of GB0004887D0 publication Critical patent/GB0004887D0/en
Priority to PCT/GB2001/000829 priority patent/WO2001064656A1/en
Priority to JP2001563498A priority patent/JP2003525279A/ja
Priority to AU3397901A priority patent/AU3397901A/xx
Priority to AT01906021T priority patent/ATE472537T1/de
Priority to IL15092001A priority patent/IL150920A0/xx
Priority to US10/203,025 priority patent/US6838464B2/en
Priority to KR1020027011409A priority patent/KR20020075463A/ko
Priority to AU2001233979A priority patent/AU2001233979B2/en
Priority to HK03105360.8A priority patent/HK1053111B/en
Priority to ES01906021T priority patent/ES2346288T3/es
Priority to BR0108879-3A priority patent/BR0108879A/pt
Priority to CA002398887A priority patent/CA2398887C/en
Priority to CNB018058469A priority patent/CN1220684C/zh
Priority to KR1020077023656A priority patent/KR100855258B1/ko
Priority to BR122014024864A priority patent/BR122014024864B8/pt
Priority to MXPA02007581A priority patent/MXPA02007581A/es
Priority to PT01906021T priority patent/PT1278735E/pt
Priority to DK01906021.9T priority patent/DK1278735T3/da
Priority to NZ520502A priority patent/NZ520502A/en
Priority to EP01906021A priority patent/EP1278735B1/en
Priority to DE60142469T priority patent/DE60142469D1/de
Priority to IL150920A priority patent/IL150920A/en
Priority to ZA200206192A priority patent/ZA200206192B/en
Priority to NO20024126A priority patent/NO325443B1/no
Priority to JP2004245381A priority patent/JP4801335B2/ja
Priority to US10/995,931 priority patent/US7067522B2/en
Priority to CY20101100784T priority patent/CY1111093T1/el
Priority to BE2021C507C priority patent/BE2021C507I2/nl
Priority to NO2021008C priority patent/NO2021008I1/no
Priority to LU00197C priority patent/LUC00197I2/fr
Priority to FR21C1010C priority patent/FR21C1010I2/fr
Priority to CY2021005C priority patent/CY2021005I2/el
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
GBGB0004887.6A 2000-03-01 2000-03-01 Chemical compounds Ceased GB0004887D0 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
GBGB0004887.6A GB0004887D0 (en) 2000-03-01 2000-03-01 Chemical compounds
EP01906021A EP1278735B1 (en) 2000-03-01 2001-02-26 2,4-di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
DE60142469T DE60142469D1 (de) 2000-03-01 2001-02-26 Imidinderivate als antineoplastika
BR122014024864A BR122014024864B8 (pt) 2000-03-01 2001-02-26 derivado de pirimidina, processo para preparar um derivado de pirimidina, composição farmacêutica, e, uso de um derivado de pirimidina
DK01906021.9T DK1278735T3 (da) 2000-03-01 2001-02-26 2,4-di(hetero-)arylamino(-oxy)-5-substituerede pyrimidiner som antineoplastiske midler
AU3397901A AU3397901A (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
AT01906021T ATE472537T1 (de) 2000-03-01 2001-02-26 2,4-di(hetero-)arylamino(-oxy)-5-substituierte pyrimidinderivate als antineoplastika
IL15092001A IL150920A0 (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
US10/203,025 US6838464B2 (en) 2000-03-01 2001-02-26 2,4-Di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineaoplastic agents
KR1020027011409A KR20020075463A (ko) 2000-03-01 2001-02-26 항신생물제로서의 2,4-디(헤테로)아릴아미노(옥시)-5-치환피리미딘
AU2001233979A AU2001233979B2 (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
HK03105360.8A HK1053111B (en) 2000-03-01 2001-02-26 2,4-di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
ES01906021T ES2346288T3 (es) 2000-03-01 2001-02-26 2,4-di(hetero-)arilamino(-oxi)-5-pirimidinas sustituidas como agentes antineoplasicos.
BR0108879-3A BR0108879A (pt) 2000-03-01 2001-02-26 Derivado de pirimidina, processo para preparar um derivado de pirimidina compósição farmacêutica, uso de um derivado de pirimidina,e, método para produzir um efeito inibidor do ciclo celular, anti-câncer (anti-proliferação celular) e/ou um efeito inibidor de fak (anti-migração celular e/ou indutor da apoptose) em um animal de sangue quente
CA002398887A CA2398887C (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
CNB018058469A CN1220684C (zh) 2000-03-01 2001-02-26 用作抗肿瘤剂的2,4－二(杂－)芳基氨基(－氧基)－5－取代的嘧啶
KR1020077023656A KR100855258B1 (ko) 2000-03-01 2001-02-26 항신생물제로서의 2,4-디(헤테로)아릴아미노(옥시)-5-치환피리미딘
PCT/GB2001/000829 WO2001064656A1 (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
MXPA02007581A MXPA02007581A (es) 2000-03-01 2001-02-26 Pirimidinas 2, 4-di (hetero-) arilamino (-oxi)-5-sustituidas como agentes antineoplasticos..
PT01906021T PT1278735E (pt) 2000-03-01 2001-02-26 2,4-di(hetero-)arilamino(-oxi)-pirimidinas substituídas na posição 5 como agentes antineoplásicos
JP2001563498A JP2003525279A (ja) 2000-03-01 2001-02-26 抗新生物薬としての２，４，ジ（ヘテロ−）アリールアミノ（−オキシ）−５−置換ピリミジン
NZ520502A NZ520502A (en) 2000-03-01 2001-02-26 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
IL150920A IL150920A (en) 2000-03-01 2002-07-25 Pyrimidine derivatives, processes for their preparation, pharmaceutical preparations containing them and their use to create drugs and drugs to create an anti-cancer effect in a warm-blooded animal
ZA200206192A ZA200206192B (en) 2000-03-01 2002-08-02 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents.
NO20024126A NO325443B1 (no) 2000-03-01 2002-08-29 Pyrimidinderivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende disse, disse forbindelsene anvendt i terapeutisk behandling samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer
JP2004245381A JP4801335B2 (ja) 2000-03-01 2004-08-25 抗新生物薬としての２，４，ジ（ヘテロ−）アリールアミノ（−オキシ）−５−置換ピリミジン
US10/995,931 US7067522B2 (en) 2000-03-01 2004-11-24 2,4,DI (hetero-) arylamino (-oxy)-5-substituted pyrimidines as antineoplastic agents
CY20101100784T CY1111093T1 (el) 2000-03-01 2010-08-26 2,4,δι(ετερο-)αρυλαμινο(-οξυ)-5-υποκατεστημενες πυριμιδινες ως μεσα κατα των νεοπλασιων
BE2021C507C BE2021C507I2 (enExample) 2000-03-01 2021-02-22
NO2021008C NO2021008I1 (no) 2000-03-01 2021-02-22 fedratinib eller et farmasøytisk akseptabelt salt derav
LU00197C LUC00197I2 (enExample) 2000-03-01 2021-02-23
FR21C1010C FR21C1010I2 (fr) 2000-03-01 2021-02-23 2,4,di-(hetero-) arylamino (-oxy)-5 pyrimidines substitutees utilisees comme agents antineoplasiques
CY2021005C CY2021005I2 (el) 2000-03-01 2021-02-24 2,4,δι(ετερο-)αρυλαμινο(-οξυ)-5-υποκατεστημενες πυριμιδινες ως μεσα κατα των νεοπλασιων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0004887.6A GB0004887D0 (en) 2000-03-01 2000-03-01 Chemical compounds

Publications (1)

Publication Number Publication Date
GB0004887D0 true GB0004887D0 (en) 2000-04-19

Family

ID=9886703

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0004887.6A Ceased GB0004887D0 (en) 2000-03-01 2000-03-01 Chemical compounds

Country Status (25)

Country Link
US (2) US6838464B2 (enExample)
EP (1) EP1278735B1 (enExample)
JP (2) JP2003525279A (enExample)
KR (2) KR20020075463A (enExample)
CN (1) CN1220684C (enExample)
AT (1) ATE472537T1 (enExample)
AU (2) AU3397901A (enExample)
BE (1) BE2021C507I2 (enExample)
BR (1) BR0108879A (enExample)
CA (1) CA2398887C (enExample)
CY (2) CY1111093T1 (enExample)
DE (1) DE60142469D1 (enExample)
DK (1) DK1278735T3 (enExample)
ES (1) ES2346288T3 (enExample)
FR (1) FR21C1010I2 (enExample)
GB (1) GB0004887D0 (enExample)
HK (1) HK1053111B (enExample)
IL (2) IL150920A0 (enExample)
LU (1) LUC00197I2 (enExample)
MX (1) MXPA02007581A (enExample)
NO (2) NO325443B1 (enExample)
NZ (1) NZ520502A (enExample)
PT (1) PT1278735E (enExample)
WO (1) WO2001064656A1 (enExample)
ZA (1) ZA200206192B (enExample)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5438299A (en) 1998-08-29 2000-03-21 Astrazeneca Ab Pyrimidine compounds
JP2002523498A (ja) 1998-08-29 2002-07-30 アストラゼネカ・アクチエボラーグ ピリミジン化合物
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB9907658D0 (en) 1999-04-06 1999-05-26 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004888D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
GB0021726D0 (en) 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
ATE346064T1 (de) 2000-09-15 2006-12-15 Vertex Pharma Pyrazolverbindungen als protein-kinasehemmer
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
IL156306A0 (en) 2000-12-21 2004-01-04 Glaxo Group Ltd Pyrimidineamines as angiogenesis modulators
WO2002068415A1 (en) * 2000-12-21 2002-09-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
HUP0401711A3 (en) 2001-06-26 2009-07-28 Bristol Myers Squibb Co N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them
US7638522B2 (en) * 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US8101629B2 (en) * 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
WO2003026664A1 (en) * 2001-09-26 2003-04-03 Bayer Corporation 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
WO2003040141A1 (en) * 2001-09-28 2003-05-15 Bayer Pharmaceuticals Corporation Oxazolyl-phenyl-2,4-diamino-pyrimidine compounds and methods for treating hyperproliferative disorders
PL370087A1 (en) * 2001-10-17 2005-05-16 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
PT1438053E (pt) 2001-10-17 2008-09-25 Boehringer Ingelheim Int Derivados de pirimidina, medicamento contendo estes compostos, sua utilização e processo para a sua preparação
EP1453516A2 (de) 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
SE0104140D0 (sv) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
WO2003055489A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation 2,4-diamino-pyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
RU2004126671A (ru) * 2002-02-06 2005-04-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Гетероарилсоединения, полезные в качестве ингибиторов gsk-3
GB0205688D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
JP2005524672A (ja) 2002-03-09 2005-08-18 アストラゼネカ アクチボラグ Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
US20040009981A1 (en) * 2002-03-15 2004-01-15 David Bebbington Compositions useful as inhibitors of protein kinases
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
AU2003231231A1 (en) * 2002-05-06 2003-11-11 Bayer Pharmaceuticals Corporation Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
RU2491071C2 (ru) * 2002-07-29 2013-08-27 Райджел Фармасьютикалз, Инк. Способы лечения или профилактики аутоиммунных заболеваний с помощью соединений 2,4-пиримидиндиамина
EP2316459B1 (en) * 2002-07-29 2013-11-06 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in methods of treating or preventing autoimmune diseases
RS51752B (sr) 2002-07-29 2011-12-31 Rigel Pharmaceuticals Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina
CN101481356B (zh) * 2002-08-09 2012-07-11 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
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