PE20110059A1 - Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa - Google Patents
Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasaInfo
- Publication number
- PE20110059A1 PE20110059A1 PE2010001193A PE2010001193A PE20110059A1 PE 20110059 A1 PE20110059 A1 PE 20110059A1 PE 2010001193 A PE2010001193 A PE 2010001193A PE 2010001193 A PE2010001193 A PE 2010001193A PE 20110059 A1 PE20110059 A1 PE 20110059A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- integer
- ona
- isoquinolin
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
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- Cardiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
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Abstract
REFERIDA A UN COMPUESTO DERIVADO DE ISOQUINOLINA O ISOQUINOLINONA DE FORMULA (I), DONDE R1 ES H, OH, O NH2; R2 ES H, HALOGENO, CN, ALQUILO C1-C6, ENTRE OTROS; R3 ES H, HALOGENO, HIDROXI, ALQUILO C1-C6, ENTRE OTROS; R4 ES H, HALOGENO, HIDROXI, ENTRE OTROS; R5 ES H, HALOGENO, CN, ALQUILO C1-C6, R'; R6 ESTA AUSENTE O ES ALQUILENO C1-C4; R7 ES H, HALOGENO, CN, ENTRE OTROS; R8 ES H, HALOGENO O ALQUILO C1-C6; R9 ES OH, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; R10 ES H, ARILO C6-C10, O-ARILO C6-C10, ENTRE OTROS; R11 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R12 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, HETEROARILO C5-C10, ENTRE OTROS; R13 Y R14 SON H, R', ALQUILO C1-C6, ALQUILENO (C1-C6)-O-ALQUILO C1-C6, ENTRE OTROS; n ES UN ENTERO DE 0 A 4; m ES UN ENTERO DE 1 A 4; s S UN ENTERO DE 0 A 3; r ES 1 O 2; L ES O(CH2)p, S(CH2)p, SO2(CH2)p, ENTRE OTROS; p ES UN ENTERO DE 0 A 4; R' ES ARILO C6-C10, CICLOALQUILO C3-C8, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[4-(1-AMINO-PROPIL)-4-(4-FLUORO-FENIL)-CICLOHEXILOXI]-7-CLORO-2H-ISOQUINOLIN-1-ONA, 6-[4-(1-AMINO-CICLOPROPIL)-4-FENIL-CICLOHEXILOXI]-7-CLORO-2H-ISOQUINOLIN-1-ONA, 6-{[4-(1-AMINOPROPIL)-4-FENILCICLOHEXIL]OXI}-7-CLORO-2H-ISOQUINOLIN-1-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA Rho QUINASA Y SON UTILES EN EL TRATAMIENTO DE HIPERTENSION, HIPERTENSION PULMONAR, RETINOPATIA, GLAUCOMA, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290606 | 2008-06-24 | ||
| US15314909P | 2009-02-17 | 2009-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110059A1 true PE20110059A1 (es) | 2011-02-15 |
Family
ID=40049863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001193A PE20110059A1 (es) | 2008-06-24 | 2009-06-19 | Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8541449B2 (es) |
| EP (1) | EP2303846B1 (es) |
| JP (1) | JP5713893B2 (es) |
| KR (1) | KR101638326B1 (es) |
| CN (1) | CN102131784B (es) |
| AR (1) | AR072281A1 (es) |
| AU (1) | AU2009262517B2 (es) |
| BR (1) | BRPI0914696A2 (es) |
| CA (1) | CA2728137C (es) |
| CO (1) | CO6321250A2 (es) |
| CR (1) | CR11831A (es) |
| DK (1) | DK2303846T3 (es) |
| DO (1) | DOP2010000394A (es) |
| EC (1) | ECSP10010705A (es) |
| ES (1) | ES2541827T3 (es) |
| HK (1) | HK1158644A1 (es) |
| HR (1) | HRP20150726T1 (es) |
| HU (1) | HUE026617T2 (es) |
| IL (1) | IL210113A (es) |
| MA (1) | MA32400B1 (es) |
| MX (1) | MX2010013975A (es) |
| MY (1) | MY157330A (es) |
| NZ (1) | NZ590070A (es) |
| PE (1) | PE20110059A1 (es) |
| PL (1) | PL2303846T3 (es) |
| PT (1) | PT2303846E (es) |
| RU (1) | RU2538588C2 (es) |
| SI (1) | SI2303846T1 (es) |
| SV (1) | SV2010003772A (es) |
| TW (1) | TWI462907B (es) |
| UY (1) | UY31925A (es) |
| WO (1) | WO2009156100A1 (es) |
| ZA (1) | ZA201008119B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5714485B2 (ja) * | 2008-06-24 | 2015-05-07 | サノフイ | ６−置換イソキノリン類及びイソキノリノン類 |
| WO2013011932A1 (ja) | 2011-07-15 | 2013-01-24 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するアザベンズイミダゾール誘導体 |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| EA201400858A1 (ru) | 2012-02-03 | 2015-01-30 | Басф Се | Фунгицидные пиримидиновые соединения |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| CN104220427A (zh) | 2012-02-03 | 2014-12-17 | 巴斯夫欧洲公司 | 杀真菌嘧啶化合物 |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113791A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2015042243A1 (en) | 2013-09-19 | 2015-03-26 | Bristol-Myers Squibb Company | Triazolopyridine ether derivatives and their use in neurological and pyschiatric disorders |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2016180918A1 (en) | 2015-05-12 | 2016-11-17 | Platod | Combination of pharmacological and microfluidic features for improved platelets production |
| JP6906105B2 (ja) * | 2017-06-16 | 2021-07-21 | 成都先導薬物開発股▲ふん▼有限公司Ｈｉｔｇｅｎ Ｌｔｄ． | Ｒｏｃｋを阻害する化合物及びその使用 |
| CN109810174B (zh) * | 2017-11-21 | 2021-01-01 | 首都医科大学 | 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| CN110317169B (zh) * | 2018-03-29 | 2022-06-03 | 复旦大学 | 一种1-取代异喹啉酮化合物及其制备方法 |
| US11738030B2 (en) | 2021-10-30 | 2023-08-29 | Aneuryst, Inc. | Treatments for disturbed cerebral homeostasis |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2702600A1 (de) * | 1977-01-22 | 1978-07-27 | Thomae Gmbh Dr K | Neue aminoalkoxyphenyl-derivate |
| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| EP0541559A1 (en) | 1990-07-31 | 1993-05-19 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| EP0956865B2 (en) | 1996-08-12 | 2010-08-18 | Mitsubishi Tanabe Pharma Corporation | MEDICINES COMPRISING Rho KINASE INHIBITOR |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| JP2001514259A (ja) | 1997-08-29 | 2001-09-11 | ゼネカ・リミテッド | アミノメチルオキソオキサゾリジニルベンゼン誘導体 |
| TW575567B (en) * | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| GB9912701D0 (en) | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
| US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| AU779442B2 (en) | 2000-01-20 | 2005-01-27 | Eisai Co. Ltd. | Novel piperidine compounds and drugs containing the same |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| AU2001239947A1 (en) | 2000-02-29 | 2001-09-12 | Curis, Inc. | Methods and compositions for regulating adipocytes |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| WO2002034712A1 (fr) | 2000-10-27 | 2002-05-02 | Takeda Chemical Industries, Ltd. | Procede de preparation de composes aromatiques substitues et produits intermediaires associes |
| JP2004520347A (ja) | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
| JP2004534017A (ja) | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｂａｃｅのインヒビター |
| JPWO2002100833A1 (ja) * | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| ATE447955T1 (de) | 2001-08-24 | 2009-11-15 | Univ Yale | Piperazinon-verbindungen als antitumorale und krebsbekämpfende mittel |
| WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| WO2004009555A1 (ja) * | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | ５−置換イソキノリン誘導体 |
| AU2003264427A1 (en) | 2002-09-12 | 2004-04-30 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
| US20040266755A1 (en) | 2003-05-29 | 2004-12-30 | Schering Aktiengesellschaft | Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine |
| US20070021404A1 (en) | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CA2539479C (en) | 2003-09-23 | 2010-07-06 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
| AU2004276236B2 (en) | 2003-09-23 | 2008-01-24 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
| EP1671962A1 (en) | 2003-10-10 | 2006-06-21 | Ono Pharmaceutical Co., Ltd. | Novel fused heterocyclic compound and use thereof |
| JP2007008816A (ja) * | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| US7449477B2 (en) | 2003-11-25 | 2008-11-11 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) |
| WO2005074535A2 (en) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Cholinesterase inhibitors for spinal cord disorders |
| WO2005087226A1 (en) | 2004-03-05 | 2005-09-22 | Eisai Co., Ltd. | Cadasil treatment with cholinesterase inhibitors |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| CA2611295C (en) * | 2005-06-28 | 2014-04-22 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of rho-kinase |
| EP1910333B1 (en) * | 2005-07-26 | 2013-05-22 | Sanofi | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| AU2006274246B2 (en) * | 2005-07-26 | 2012-07-12 | Sanofi-Aventis | Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors |
| TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| US7618985B2 (en) * | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| US7893088B2 (en) * | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| BRPI0720986A2 (pt) * | 2006-12-27 | 2014-03-11 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos |
| RS51655B (en) * | 2006-12-27 | 2011-10-31 | Sanofi-Aventis | Isoquinoline derivatives and isoquinolinone derivatives substituted by cycloalkylamine |
| DE602007013295D1 (de) | 2006-12-27 | 2011-04-28 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| CA2673916C (en) * | 2006-12-27 | 2015-02-17 | Sanofi-Aventis | Substituted isoquinolone and isoquinolinone derivatives as inhibitors of rho-kinase |
| EP2125746B1 (en) * | 2006-12-27 | 2012-04-18 | Sanofi | Cycloalkylamine substituted isoquinoline derivatives |
| BRPI0720710A2 (pt) * | 2006-12-27 | 2014-12-23 | Sanofi Aventis | Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina |
| EP2125745B1 (en) * | 2006-12-27 | 2017-02-22 | Sanofi | Cycloalkylamine substituted isoquinolone derivatives |
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