MA32400B1 - Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase - Google Patents

Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase

Info

Publication number
MA32400B1
MA32400B1 MA33438A MA33438A MA32400B1 MA 32400 B1 MA32400 B1 MA 32400B1 MA 33438 A MA33438 A MA 33438A MA 33438 A MA33438 A MA 33438A MA 32400 B1 MA32400 B1 MA 32400B1
Authority
MA
Morocco
Prior art keywords
substituted
isocoinolinase
isocoinolin
kinase inhibitors
kinase
Prior art date
Application number
MA33438A
Other languages
Arabic (ar)
English (en)
Inventor
Oliver Plettenburg
Katrin Lorenz
John Weston
Matthias Loehn
Heinz-Werner Kleemann
Olivier Duclos
Frédéric Jeannot
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA32400B1 publication Critical patent/MA32400B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Cette invention concerne des isoquinolines et isoquinolinones substituées de formule (i) utilisées dans le traitement et/ou la prévention des maladies associées avec la rho-kinase et/ou la phosphorylation par l'intermédiaire de la rho-kinase de la phosphatase des chaînes légères de myosine, et des compositions contenant ces types de composés.
MA33438A 2008-06-24 2010-12-17 Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase MA32400B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290606 2008-06-24
PCT/EP2009/004421 WO2009156100A1 (fr) 2008-06-24 2009-06-19 Isoquinolines et isoquinolinones substituées utilisées comme inhibiteurs de rho-kinase

Publications (1)

Publication Number Publication Date
MA32400B1 true MA32400B1 (fr) 2011-06-01

Family

ID=40049863

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33438A MA32400B1 (fr) 2008-06-24 2010-12-17 Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase

Country Status (33)

Country Link
US (1) US8541449B2 (fr)
EP (1) EP2303846B1 (fr)
JP (1) JP5713893B2 (fr)
KR (1) KR101638326B1 (fr)
CN (1) CN102131784B (fr)
AR (1) AR072281A1 (fr)
AU (1) AU2009262517B2 (fr)
BR (1) BRPI0914696A2 (fr)
CA (1) CA2728137C (fr)
CO (1) CO6321250A2 (fr)
CR (1) CR11831A (fr)
DK (1) DK2303846T3 (fr)
DO (1) DOP2010000394A (fr)
EC (1) ECSP10010705A (fr)
ES (1) ES2541827T3 (fr)
HK (1) HK1158644A1 (fr)
HR (1) HRP20150726T1 (fr)
HU (1) HUE026617T2 (fr)
IL (1) IL210113A (fr)
MA (1) MA32400B1 (fr)
MX (1) MX2010013975A (fr)
MY (1) MY157330A (fr)
NZ (1) NZ590070A (fr)
PE (1) PE20110059A1 (fr)
PL (1) PL2303846T3 (fr)
PT (1) PT2303846E (fr)
RU (1) RU2538588C2 (fr)
SI (1) SI2303846T1 (fr)
SV (1) SV2010003772A (fr)
TW (1) TWI462907B (fr)
UY (1) UY31925A (fr)
WO (1) WO2009156100A1 (fr)
ZA (1) ZA201008119B (fr)

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KR20140040801A (ko) 2011-07-15 2014-04-03 시오노기세야쿠 가부시키가이샤 Ａｍｐｋ 활성화 작용을 갖는 아자벤즈이미다졸 유도체
WO2013113716A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
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WO2013113791A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
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WO2013113720A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
BR112014018909A8 (pt) 2012-02-03 2017-07-11 Basf Se Compostos, processo para a preparação dos compostos, composição agroquímica, método para o combate dos fungos, utilização dos compostos e semente
WO2013113776A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
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US20180104692A1 (en) 2015-05-12 2018-04-19 Platod Combination of pharmacological and microfluidic features for improved platelets production
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CN109810174B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用
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MX2009005966A (es) 2006-12-27 2009-06-15 Sanofi Aventis Derivados de isoquinolona sustituidos con cicloalquilamina.
CN101578266B (zh) 2006-12-27 2013-10-30 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹啉和异喹啉酮衍生物
RU2009128690A (ru) 2006-12-27 2011-02-10 Санофи-Авентис (Fr) Новые замещенные производные изохинолина и изохинолинона
MX2009006517A (es) 2006-12-27 2009-06-26 Sanofi Aventis Nuevos derivados de isoquinolina e isoquinolinona sustituidos.
CA2673916C (fr) 2006-12-27 2015-02-17 Sanofi-Aventis Derives d'isoquinoline et d'isoquinolinone substitues inhibiteurs de la rho-kinase
MX2009005828A (es) 2006-12-27 2009-06-16 Sanofi Aventis Derivados de isoquinolona e isoquinolinona sustituidos con cicloalquilamina.

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RU2011102456A (ru) 2012-07-27
JP5713893B2 (ja) 2015-05-07
WO2009156100A1 (fr) 2009-12-30
KR20110021922A (ko) 2011-03-04
IL210113A (en) 2015-10-29
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