FR2649720A1 - Recombinant gene which encodes a protein such as urate oxidase - Google Patents
Recombinant gene which encodes a protein such as urate oxidase Download PDFInfo
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- FR2649720A1 FR2649720A1 FR8909550A FR8909550A FR2649720A1 FR 2649720 A1 FR2649720 A1 FR 2649720A1 FR 8909550 A FR8909550 A FR 8909550A FR 8909550 A FR8909550 A FR 8909550A FR 2649720 A1 FR2649720 A1 FR 2649720A1
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 108010022394 Threonine synthase Proteins 0.000 description 1
- 208000035317 Total hypoxanthine-guanine phosphoribosyl transferase deficiency Diseases 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 108010093894 Xanthine oxidase Proteins 0.000 description 1
- 102100033220 Xanthine oxidase Human genes 0.000 description 1
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 description 1
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- 239000002250 absorbent Substances 0.000 description 1
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- 201000001509 acute urate nephropathy Diseases 0.000 description 1
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- 235000004279 alanine Nutrition 0.000 description 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 description 1
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- 125000000539 amino acid group Chemical group 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
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- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
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- 235000003704 aspartic acid Nutrition 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000006652 catabolic pathway Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- GSOLWAFGMNOBSY-UHFFFAOYSA-N cobalt Chemical compound [Co][Co][Co][Co][Co][Co][Co][Co] GSOLWAFGMNOBSY-UHFFFAOYSA-N 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 102000004419 dihydrofolate reductase Human genes 0.000 description 1
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- 239000012895 dilution Substances 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
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- 230000002068 genetic effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- XMBWDFGMSWQBCA-YPZZEJLDSA-N iodane Chemical compound [125IH] XMBWDFGMSWQBCA-YPZZEJLDSA-N 0.000 description 1
- 229940044173 iodine-125 Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012160 loading buffer Substances 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000858 peroxisomal effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 108010048397 seryl-lysyl-leucine Proteins 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 208000019808 uric acid nephrolithiasis Diseases 0.000 description 1
- 230000003424 uricosuric effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8909550A FR2649720A1 (en) | 1989-07-13 | 1989-07-13 | Recombinant gene which encodes a protein such as urate oxidase |
| NZ234453A NZ234453A (en) | 1989-07-13 | 1990-07-11 | Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith |
| IL95057A IL95057A (en) | 1989-07-13 | 1990-07-12 | Recombinant gene coding for a protein possessing urate oxidase activity |
| PT94680A PT94680B (pt) | 1989-07-13 | 1990-07-12 | Processo para a obtencao de uma proteina tendo actividade de urato oxidase gene recombinante que a codifica vector de expressao portador deste gene microorganismos procariotas e celulas eucariotas transformados por este vector de expressao |
| DK90402023.7T DK0408461T3 (da) | 1989-07-13 | 1990-07-13 | Protein med uratoxidase-aktivitet, rekombinant gen, der koder for proteinet, samt ekspressionsvektor, mikroorganismer og transformerede celler |
| DE69028884T DE69028884T2 (de) | 1989-07-13 | 1990-07-13 | Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten |
| DE2001199042 DE10199042I2 (de) | 1989-07-13 | 1990-07-13 | Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten |
| MC@@@@D MC2145A1 (fr) | 1989-07-13 | 1990-07-13 | Proteine a activite urate oxydase,gene recombinant codant pour celle-ci,vecteur d'expression,micro-organismes et cellules transformees |
| CA002035900A CA2035900C (fr) | 1989-07-13 | 1990-07-13 | Proteine a activite urate oxydase, gene recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformees |
| AT90402023T ATE144282T1 (de) | 1989-07-13 | 1990-07-13 | Protein mit urate-oxidase-aktivität, dafür kodierendes rekombinantes gen, expressionsvektor, mikroorganismen und transformanten |
| BR909006855A BR9006855A (pt) | 1989-07-13 | 1990-07-13 | Proteina de atividade urato oxidase,gene recombinante que a codifica,vetor de expressao,microorganismos e celulas transformadas |
| KR1019910700276A KR0159107B1 (ko) | 1989-07-13 | 1990-07-13 | 우레이트 산화효소 활성 단백질, 이 단백질을 암호화하는 재조합 유전자, 발현 벡터, 미생물 및 형질전환세포 |
| EP90402023A EP0408461B1 (fr) | 1989-07-13 | 1990-07-13 | Protéine à activité urate oxydase, gène recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformées |
| US07/920,519 US5382518A (en) | 1989-07-13 | 1990-07-13 | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| AU60523/90A AU636637B2 (en) | 1989-07-13 | 1990-07-13 | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| SU4895030/13A RU2105812C1 (ru) | 1989-07-13 | 1990-07-13 | Полипептид, обладающий уратоксидазной активностью, фрагмент днк, обеспечивающий экспрессию полипептида с уратоксидазной активностью (варианты), вектор экспрессии, содержащий фрагмент днк, обеспечивающий экспрессию полипептида с уратоксидазной активностью (варианты), штамм, экспрессирующий полипептид, обладающий уратоксидазной активностью (варианты), способ получения полипептида, обладающего уратоксидазной активностью |
| IE255990A IE77158B1 (en) | 1989-07-13 | 1990-07-13 | Protein with urate oxidase activity recombinant gene coding therefor expression vector micro-organisms and transformed cells |
| ZA905516A ZA905516B (en) | 1989-07-13 | 1990-07-13 | Recombinant gene coding for a protein such as urate oxidase |
| ES90402023T ES2095243T3 (es) | 1989-07-13 | 1990-07-13 | Proteina de actividad urato oxidasa; gen recombinante codante para esta, vector de expresion, micro-organismos y celulas transformadas. |
| HU906046A HU215948B (hu) | 1989-07-13 | 1990-07-13 | Eljárás urát-oxidáz aktivitással rendelkező protein, azt kódoló gén, expressziós vektor és mikroorganizmusok előállítására |
| PCT/FR1990/000532 WO1991000909A1 (fr) | 1989-07-13 | 1990-07-13 | Proteine a activite urate oxydase, gene recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformees |
| JP2510514A JP2664804B2 (ja) | 1989-07-13 | 1990-07-13 | 尿酸オキシダーゼ活性蛋白質、それをコードした組換え遺伝子、発現ベクター、微生物および形質転換細胞 |
| NO910982A NO308139B1 (no) | 1989-07-13 | 1991-03-12 | FremgangsmÕte for fremstilling av rekombinant protein som har spesifikk uratoksydaseaktivitet, rekombinant gen som koder for proteinet, ekspresjonsvektor samt vertsceller som inneholder de rekombinante gen |
| FI911212A FI105047B (fi) | 1989-07-13 | 1991-03-12 | Menetelmä uraattioksidaasiaktiivisuutta, omaavan yhdistelmäproteiinin valmistamiseksi, tätä proteiinia koodittava yhdistelmägeeni, ja tämän sisältävät ekspressiovektorit, mikro-organismit ja transformoidut solut |
| US08/314,586 US5541098A (en) | 1989-07-13 | 1994-09-28 | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| GR960403531T GR3022085T3 (en) | 1989-07-13 | 1996-12-18 | Protein with urate oxidase activity, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| HK97101519.4A HK1000099B (en) | 1989-07-13 | 1997-07-08 | Protein with urate oxidase activity, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| LVP-97-200A LV12000B (lv) | 1989-07-13 | 1997-10-15 | Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana |
| LU90781C LU90781I2 (fr) | 1989-07-13 | 2001-05-23 | Fasturtec -rasburicase |
| NL300046C NL300046I2 (nl) | 1989-07-13 | 2001-06-12 | Eiwit met uraat oxidase activiteit, recombinant gen dat hiervoor codeert, expressievector, micro-organismen en getransformeerde cellen. |
| NO2001018C NO2001018I2 (no) | 1989-07-13 | 2001-10-30 | Rasburicase |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8909550A FR2649720A1 (en) | 1989-07-13 | 1989-07-13 | Recombinant gene which encodes a protein such as urate oxidase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2649720A1 true FR2649720A1 (en) | 1991-01-18 |
| FR2649720B1 FR2649720B1 (enExample) | 1994-08-19 |
Family
ID=9383818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8909550A Granted FR2649720A1 (en) | 1989-07-13 | 1989-07-13 | Recombinant gene which encodes a protein such as urate oxidase |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR2649720A1 (enExample) |
| ZA (1) | ZA905516B (enExample) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3810820A (en) * | 1967-03-29 | 1974-05-14 | Applic Biochimiques Soc Et | Urate oxidase and process for the production thereof |
| WO1988008450A1 (en) * | 1987-05-01 | 1988-11-03 | Birdwell Finlayson | Gene therapy for metabolite disorders |
| EP0173378B1 (en) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism |
-
1989
- 1989-07-13 FR FR8909550A patent/FR2649720A1/fr active Granted
-
1990
- 1990-07-13 ZA ZA905516A patent/ZA905516B/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3810820A (en) * | 1967-03-29 | 1974-05-14 | Applic Biochimiques Soc Et | Urate oxidase and process for the production thereof |
| EP0173378B1 (en) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism |
| WO1988008450A1 (en) * | 1987-05-01 | 1988-11-03 | Birdwell Finlayson | Gene therapy for metabolite disorders |
Non-Patent Citations (4)
| Title |
|---|
| APPLIED AND ENVIROMENTAL MICROBIOLOGY * |
| CHEMICAL ABSTRACTS * |
| EUR. J. BIOCHEM. * |
| PROC. NATL. ACAD. SCI. USA * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA905516B (en) | 1991-04-24 |
| FR2649720B1 (enExample) | 1994-08-19 |
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