FR2649319A1 - Formulations a liberation prolongee de peptides solubles dans l'eau - Google Patents

Formulations a liberation prolongee de peptides solubles dans l'eau Download PDF

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Publication number
FR2649319A1
FR2649319A1 FR9008718A FR9008718A FR2649319A1 FR 2649319 A1 FR2649319 A1 FR 2649319A1 FR 9008718 A FR9008718 A FR 9008718A FR 9008718 A FR9008718 A FR 9008718A FR 2649319 A1 FR2649319 A1 FR 2649319A1
Authority
FR
France
Prior art keywords
water
microparticles
active ingredient
days
emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9008718A
Other languages
English (en)
French (fr)
Other versions
FR2649319B1 (es
Inventor
David Bodmer
Jones Wing Fong
Thomas Kissel
Hawkins Valliant Maulding
Oskar Nagele
Jane Edna Pearson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2649319A1 publication Critical patent/FR2649319A1/fr
Application granted granted Critical
Publication of FR2649319B1 publication Critical patent/FR2649319B1/fr
Granted legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR9008718A 1989-07-07 1990-07-05 Formulations a liberation prolongee de peptides solubles dans l'eau Granted FR2649319A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US41134789A 1989-09-22 1989-09-22

Publications (2)

Publication Number Publication Date
FR2649319A1 true FR2649319A1 (fr) 1991-01-11
FR2649319B1 FR2649319B1 (es) 1994-12-09

Family

ID=27007654

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9008718A Granted FR2649319A1 (fr) 1989-07-07 1990-07-05 Formulations a liberation prolongee de peptides solubles dans l'eau

Country Status (27)

Country Link
JP (5) JPH0832624B2 (es)
KR (2) KR100303681B1 (es)
AT (1) AT406225B (es)
AU (2) AU641407B2 (es)
BE (1) BE1004486A3 (es)
CA (1) CA2020477C (es)
CH (1) CH685230A5 (es)
CY (1) CY1965A (es)
DE (2) DE4042752B4 (es)
DK (1) DK175849B1 (es)
FI (3) FI108611B (es)
FR (1) FR2649319A1 (es)
GB (2) GB2234896B (es)
GR (1) GR1001121B (es)
HK (2) HK97695A (es)
HU (2) HU221294B1 (es)
IE (2) IE64216B1 (es)
IL (3) IL94983A (es)
IT (1) IT1241460B (es)
LU (1) LU87764A1 (es)
MY (1) MY106722A (es)
NL (1) NL195027C (es)
NO (2) NO302928B1 (es)
NZ (1) NZ234384A (es)
PT (1) PT94628B (es)
SE (1) SE512992C2 (es)
SG (1) SG26416G (es)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457834A1 (en) * 1989-02-08 1991-11-27 Biosearch Inc SPREAD RELEASE DOSAGE FORM.
EP0505966A1 (de) * 1991-03-25 1992-09-30 Hoechst Aktiengesellschaft Langwirkende bioabbaubare Mikropartikel und ein Verfahren zur Herstellung
FR2679450A1 (fr) * 1991-07-22 1993-01-29 Debio Rech Pharma Sa Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques.
EP0626170A2 (en) * 1993-05-10 1994-11-30 Sandoz Ltd. Stabilisation of pharmacologically active compounds in sustained release compositions
WO1994027718A1 (en) * 1993-05-25 1994-12-08 Hagan Derek Thomas O Preparation of microparticles and method of immunization
US5603960A (en) * 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization

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US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
DE4218510A1 (de) * 1992-06-02 1993-12-09 Pharmatech Gmbh Verfahren zur Herstellung biologisch abbaubarer Polyester
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
DK0729357T3 (da) 1993-11-19 2005-06-06 Janssen Pharmaceutica Nv Mikroindkapslede 1,2-benzazoler
EP0862419B2 (en) 1995-11-09 2010-11-17 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6226656B1 (en) 1998-11-12 2001-05-01 Sourcefinder, Inc. System and method for creating, generating and processing user-defined generic specs
US7107268B1 (en) 1998-11-12 2006-09-12 Printable Technologies, Inc. Centralized system and method for managing enterprise operations
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100392501B1 (ko) * 2000-06-28 2003-07-22 동국제약 주식회사 다중 에멀젼법에 의한 서방출성 미립구의 제조방법
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
JP2004516262A (ja) 2000-12-21 2004-06-03 ネクター セラピューティクス 親水性活性剤を含有するマイクロ粒子の製造のための誘発相転移法
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
PE20050285A1 (es) * 2003-06-24 2005-06-09 Novartis Ag Composicion farmaceutica que comprende analogos ciclicos de somatostatina
JP2008518881A (ja) * 2003-07-18 2008-06-05 オークウッド ラボラトリーズ，エル．エル．シー． 高分子組成物中の高分子の分子量低下、不純物形成およびゲル化の防止
MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
JPWO2005082405A1 (ja) * 2004-02-26 2007-10-25 独立行政法人科学技術振興機構 たんぱく性薬物の注射用徐放性微粒子製剤およびその製造法
DE102004053373A1 (de) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Erfindung betreffend anisometrische Partikel in Form von Nano-/Meso-Fasern -Röhren, -Kabeln -Bändern und deren gekrümmte oder verzweigte Abwandlungen
KR100741867B1 (ko) * 2005-07-05 2007-07-24 전북대학교산학협력단 수중유적 및 용매 증발법을 이용한 이중층 미립구의제조방법
KR20130024987A (ko) * 2005-12-22 2013-03-08 노파르티스 아게 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
CA2713339C (en) 2008-01-30 2017-01-17 Novartis Ag Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CA2813301A1 (en) * 2010-09-30 2012-04-05 Evonik Corporation Method for removing residual organic solvent from microparticles
WO2012044675A2 (en) * 2010-09-30 2012-04-05 Surmodics Pharmaceuticals, Inc. Emulsion method for preparing low residual solvent microparticles
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
KR102464650B1 (ko) 2016-05-03 2022-11-10 엘에스일렉트릭(주) 배선용 차단기의 한류장치
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统

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FR2070153A1 (es) * 1969-10-23 1971-09-10 Du Pont
FR2400950A1 (fr) * 1977-08-25 1979-03-23 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0142272A1 (en) * 1983-10-11 1985-05-22 The Administrators Of The Tulane University Educational Fund Peptides and their use in therapy
EP0145240A2 (en) * 1983-11-04 1985-06-19 Takeda Chemical Industries, Ltd. Method for producing Microcapsule
EP0190833A2 (en) * 1985-02-07 1986-08-13 Takeda Chemical Industries, Ltd. Method for producing microcapsule

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DE19375086I2 (de) * 1979-11-27 2003-01-09 Novartis Ag Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (es) * 1969-10-23 1971-09-10 Du Pont
FR2400950A1 (fr) * 1977-08-25 1979-03-23 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0142272A1 (en) * 1983-10-11 1985-05-22 The Administrators Of The Tulane University Educational Fund Peptides and their use in therapy
EP0145240A2 (en) * 1983-11-04 1985-06-19 Takeda Chemical Industries, Ltd. Method for producing Microcapsule
EP0190833A2 (en) * 1985-02-07 1986-08-13 Takeda Chemical Industries, Ltd. Method for producing microcapsule

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457834A1 (en) * 1989-02-08 1991-11-27 Biosearch Inc SPREAD RELEASE DOSAGE FORM.
EP0457834A4 (en) * 1989-02-08 1992-01-22 Biosearch, Inc. Sustained release dosage form
EP0505966A1 (de) * 1991-03-25 1992-09-30 Hoechst Aktiengesellschaft Langwirkende bioabbaubare Mikropartikel und ein Verfahren zur Herstellung
BE1005697A5 (fr) * 1991-07-22 1993-12-21 Debio Rech Pharma Sa Procede pour la preparation de microspheres en materiau polymere biodegradable.
ES2050070A1 (es) * 1991-07-22 1994-05-01 Asta Medica Ag Procedimiento para la preparacion de una composicion destinada a la liberacion prolongada y controlada de una substancia peptidica.
FR2680109A1 (fr) * 1991-07-22 1993-02-12 Debio Rech Pharma Sa Composition pour la liberation prolongee et controlee et controlee d'une substance medicamenteuse peptidique et procede pour sa preparation.
GR920100323A (el) * 1991-07-22 1993-05-24 Debio Rech Pharma Sa Μία μέ?οδος παρασκευής μικροσφαιρίων αποτελούμενων από ένα βιοαποικοδομούμενο πολυμερικό υλικό.
BE1005696A3 (fr) * 1991-07-22 1993-12-21 Asta Medica Ag Composition pour la liberation prolongee et controlee d'une substance medicamenteuse peptidique et procede pour sa preparation.
FR2679450A1 (fr) * 1991-07-22 1993-01-29 Debio Rech Pharma Sa Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques.
GR1001446B (el) * 1991-07-22 1993-12-30 Asta Medica Ag Μία σύν?εση για παρατεταμένη και ελεγχόμενη έκλυση φαρμακευτικών ουσιών και μία μέ?οδος παρασκευής τους.
WO1993001802A1 (fr) * 1991-07-22 1993-02-04 Asta Medica Aktiengesellschaft Composition pour la liberation prolongee et controlee d'une substance medicamenteuse peptidique et procede pour sa preparation
AT408609B (de) * 1991-07-22 2002-01-25 Asta Medica Ag Zubereitung zur stetigen und kontrollierten abgabe von medikamentösen substanzen und verfahren zu deren herstellung
US5637568A (en) * 1991-07-22 1997-06-10 Asta Medica Ag Composition for the sustained and controlled release of medicamentous substances and a process for preparing the same
EP0626170A3 (en) * 1993-05-10 1996-03-27 Sandoz Ltd Stabilization of pharmacoligically active compounds in controlled release compositions.
EP0626170A2 (en) * 1993-05-10 1994-11-30 Sandoz Ltd. Stabilisation of pharmacologically active compounds in sustained release compositions
US5603960A (en) * 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization
WO1994027718A1 (en) * 1993-05-25 1994-12-08 Hagan Derek Thomas O Preparation of microparticles and method of immunization

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AU5874690A (en) 1991-01-10
GB2265311A (en) 1993-09-29
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HUT54037A (en) 1991-01-28
FR2649319B1 (es) 1994-12-09
DE4021517B4 (de) 2009-04-09
DK162590D0 (da) 1990-07-05
CA2020477C (en) 2000-11-21
JPH07285853A (ja) 1995-10-31
IE64411B1 (en) 1995-08-09
SE9002364L (sv) 1991-01-08
PT94628A (pt) 1991-03-20
JPH08198771A (ja) 1996-08-06
NO903001D0 (no) 1990-07-05
GB2234896B (en) 1994-01-19
JP2001233897A (ja) 2001-08-28
AU687553B2 (en) 1998-02-26
KR100303681B1 (ko) 2002-05-16
NL195027B (nl) 2003-08-01
IT1241460B (it) 1994-01-17
IL94983A (en) 1999-08-17
CY1965A (en) 1997-07-04
SG26416G (en) 1995-09-01
JP2931773B2 (ja) 1999-08-09
HU221294B1 (en) 2002-09-28
ATA144090A (de) 1999-08-15
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JPH07309897A (ja) 1995-11-28
GB9014704D0 (en) 1990-08-22
JPH0368511A (ja) 1991-03-25
NL195027C (nl) 2003-12-02
NO983923D0 (no) 1998-08-26
SE512992C2 (sv) 2000-06-12
FI20000059A (fi) 2000-01-12
SE9002364D0 (sv) 1990-07-05
NO983923L (no) 1991-01-08
CA2020477A1 (en) 1991-01-08
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BE1004486A3 (fr) 1992-12-01
IL131880A (en) 2001-12-23
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DE4042752B4 (de) 2009-05-07
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DK162590A (da) 1991-01-08
HK97695A (en) 1995-06-23
AU2332195A (en) 1995-09-07
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NO903001L (no) 1991-01-08
IL94983A0 (en) 1991-06-10
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LU87764A1 (fr) 1992-03-11
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MY106722A (en) 1995-07-31
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AU641407B2 (en) 1993-09-23
DE4021517A1 (de) 1991-01-17
HK197496A (en) 1996-11-08
IT9048113A0 (it) 1990-07-05
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