FR2400950A1 - Procede de preparation de microspheres comportant un noyau solide et une matiere polymere - Google Patents

Procede de preparation de microspheres comportant un noyau solide et une matiere polymere

Info

Publication number
FR2400950A1
FR2400950A1 FR7824597A FR7824597A FR2400950A1 FR 2400950 A1 FR2400950 A1 FR 2400950A1 FR 7824597 A FR7824597 A FR 7824597A FR 7824597 A FR7824597 A FR 7824597A FR 2400950 A1 FR2400950 A1 FR 2400950A1
Authority
FR
France
Prior art keywords
polymeric material
solid core
preparing microspheres
microspheres
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7824597A
Other languages
English (en)
Other versions
FR2400950B1 (fr
Inventor
Jones Wing Fong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2400950A1 publication Critical patent/FR2400950A1/fr
Application granted granted Critical
Publication of FR2400950B1 publication Critical patent/FR2400950B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/62—Coated
    • A61K2800/624—Coated by macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/654—The particulate/core comprising macromolecular material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

L'invention concerne un procédé de préparation de microsphères comportant un noyau solide et une matière polymère. Selon le procédé de l'invention, on ajoute à une température comprise entre - 100 et - 40 degrés C un agent de séparation de phases à un milieu formé d'une solution du polymère et d'une dispersion ou d'une solution de la matière utilisée comme noyau. Les microsphères ainsi obtenues peuvent être utilisées, entre autres, comme médicaments à action retardée.
FR7824597A 1977-08-25 1978-08-24 Procede de preparation de microspheres comportant un noyau solide et une matiere polymere Granted FR2400950A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82771077A 1977-08-25 1977-08-25

Publications (2)

Publication Number Publication Date
FR2400950A1 true FR2400950A1 (fr) 1979-03-23
FR2400950B1 FR2400950B1 (fr) 1983-10-07

Family

ID=25249947

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7824597A Granted FR2400950A1 (fr) 1977-08-25 1978-08-24 Procede de preparation de microspheres comportant un noyau solide et une matiere polymere

Country Status (21)

Country Link
JP (1) JPS5455717A (fr)
AT (1) AT372019B (fr)
AU (1) AU522215B2 (fr)
BE (1) BE869915A (fr)
CA (1) CA1122077A (fr)
CH (2) CH649217A5 (fr)
DE (1) DE2836044A1 (fr)
DK (2) DK361878A (fr)
ES (1) ES472800A1 (fr)
FI (1) FI64899C (fr)
FR (1) FR2400950A1 (fr)
GB (1) GB2003108B (fr)
IE (1) IE47255B1 (fr)
IL (1) IL55418A (fr)
IT (1) IT1098111B (fr)
NL (1) NL7808613A (fr)
NZ (1) NZ188232A (fr)
PH (1) PH15447A (fr)
PT (1) PT68473A (fr)
SE (1) SE431942B (fr)
ZA (1) ZA784855B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2484281A1 (fr) * 1980-06-13 1981-12-18 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0052510A2 (fr) * 1980-11-18 1982-05-26 Syntex (U.S.A.) Inc. Microencapsulation de polypeptides hydrosolubles
EP0108882A1 (fr) * 1982-10-15 1984-05-23 Chemie Linz Aktiengesellschaft Comprimés à libération retardée de la substance active et leur procédé de préparation
EP0164571A2 (fr) * 1984-05-11 1985-12-18 Cl Pharma Aktiengesellschaft Formes retard du alpha-(2,5-diméthoxy phényl)-bêta-glycinamidoéthanol et procédé pour leur fabrication
EP0172422A2 (fr) * 1984-08-01 1986-02-26 Hoechst Aktiengesellschaft Microcapsules de peptides régulatrices à libération contrôlée, leur préparation et formulations injectables
FR2571617A1 (fr) * 1984-10-17 1986-04-18 Debiopharm Sa Procede pour la microencapsulation par separation de phases de substances medicamenteuses hydrosolubles
EP0285871A2 (fr) * 1987-04-10 1988-10-12 PCD-Polymere Gesellschaft m.b.H. Granule à libération prolongée ne contenant pas d'agent liant
FR2649319A1 (fr) * 1989-07-07 1991-01-11 Sandoz Sa Formulations a liberation prolongee de peptides solubles dans l'eau
AT392891B (de) * 1986-01-13 1991-06-25 Marpal Ag Liegemoebel
FR2657255A1 (fr) * 1989-12-27 1991-07-26 Sederma Sa Description de preparations cosmetiques originales dont les principes actifs sont pieges dans un reseau polymerique greffe a la surface de particules de silice.

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045845B2 (ja) * 1979-10-31 1985-10-12 田辺製薬株式会社 医薬物質含有マイクロカプセルの製法
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
JPS5933214A (ja) * 1982-08-19 1984-02-23 Mitsui Toatsu Chem Inc 微小球に製剤された制ガン剤の製造方法
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
DE4127757A1 (de) * 1991-02-06 1992-08-13 Hoechst Ag Neue pflanzenschutzmittel-formulierungen
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
AU2001258127B2 (en) * 2000-05-12 2005-11-10 Matregen Corp. Method of producing structures using centrifugal forces
US6969480B2 (en) 2000-05-12 2005-11-29 Matregen Corp. Method of producing structures using centrifugal forces
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
EP2219775A4 (fr) * 2007-12-11 2012-10-03 Univ Nanyang Tech Microsphères creuses multicouches pour l'administration de composés actifs hydrophiles
AU2009250453B2 (en) * 2008-05-21 2014-07-10 Toray Industries, Inc. Method for producing polymer fine particle
CN103828801B (zh) * 2014-01-15 2016-01-27 福建农林大学 多杀菌素/甲氨基阿维菌素苯甲酸盐微球及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427250A (en) * 1963-03-25 1969-02-11 Polaroid Corp Microscopic capsules and process for their preparation
GB1198513A (en) * 1966-08-11 1970-07-15 Roussel Uclaf A Process for the Preparation of Homogeneous Beadlets Incorporating Active Ingredients(s).
FR2070153A1 (fr) * 1969-10-23 1971-09-10 Du Pont
US3703474A (en) * 1967-08-21 1972-11-21 Ncr Co Encapsulation process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT631615A (fr) * 1960-02-26
US3531418A (en) * 1965-08-18 1970-09-29 Ncr Co En masse encapsulation process
JPS51125675A (en) * 1975-02-13 1976-11-02 Asahi Chem Ind Co Ltd A porous capsule structvre and a process for manufacturing turing it

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427250A (en) * 1963-03-25 1969-02-11 Polaroid Corp Microscopic capsules and process for their preparation
GB1198513A (en) * 1966-08-11 1970-07-15 Roussel Uclaf A Process for the Preparation of Homogeneous Beadlets Incorporating Active Ingredients(s).
US3703474A (en) * 1967-08-21 1972-11-21 Ncr Co Encapsulation process
FR2070153A1 (fr) * 1969-10-23 1971-09-10 Du Pont

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2484281A1 (fr) * 1980-06-13 1981-12-18 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0052510A2 (fr) * 1980-11-18 1982-05-26 Syntex (U.S.A.) Inc. Microencapsulation de polypeptides hydrosolubles
EP0052510A3 (en) * 1980-11-18 1982-09-08 Syntex (U.S.A.) Inc. Microencapsulation of water soluble polypeptides
EP0108882A1 (fr) * 1982-10-15 1984-05-23 Chemie Linz Aktiengesellschaft Comprimés à libération retardée de la substance active et leur procédé de préparation
EP0164571A3 (en) * 1984-05-11 1987-04-22 Chemie Linz Aktiengesellschaft Sustained-release forms of alpha-(2,5-dimethoxy phenyl)-beta-glycinamidoethanol and process for their preparation
EP0164571A2 (fr) * 1984-05-11 1985-12-18 Cl Pharma Aktiengesellschaft Formes retard du alpha-(2,5-diméthoxy phényl)-bêta-glycinamidoéthanol et procédé pour leur fabrication
EP0172422A2 (fr) * 1984-08-01 1986-02-26 Hoechst Aktiengesellschaft Microcapsules de peptides régulatrices à libération contrôlée, leur préparation et formulations injectables
EP0172422A3 (fr) * 1984-08-01 1986-05-07 Hoechst Aktiengesellschaft Microcapsules de peptides régulatrices à libération contrôlée, leur préparation et formulations injectables
FR2571617A1 (fr) * 1984-10-17 1986-04-18 Debiopharm Sa Procede pour la microencapsulation par separation de phases de substances medicamenteuses hydrosolubles
AT392891B (de) * 1986-01-13 1991-06-25 Marpal Ag Liegemoebel
EP0285871A2 (fr) * 1987-04-10 1988-10-12 PCD-Polymere Gesellschaft m.b.H. Granule à libération prolongée ne contenant pas d'agent liant
EP0285871A3 (en) * 1987-04-10 1989-12-13 Chemie Holding Aktiengesellschaft Sustained release granulate without binding agent
FR2649319A1 (fr) * 1989-07-07 1991-01-11 Sandoz Sa Formulations a liberation prolongee de peptides solubles dans l'eau
GR900100513A (en) * 1989-07-07 1991-12-10 Sandoz Ag Reinforced compositions for the release of peptides soluble in water
BE1004486A3 (fr) * 1989-07-07 1992-12-01 Sandoz Sa Formulations a liberation prolongee de peptides solubles dans l'eau.
FR2657255A1 (fr) * 1989-12-27 1991-07-26 Sederma Sa Description de preparations cosmetiques originales dont les principes actifs sont pieges dans un reseau polymerique greffe a la surface de particules de silice.

Also Published As

Publication number Publication date
JPS645005B2 (fr) 1989-01-27
IL55418A (en) 1981-07-31
SE7808759L (sv) 1979-02-26
SE431942B (sv) 1984-03-12
NZ188232A (en) 1980-12-19
AU522215B2 (en) 1982-05-20
JPS5455717A (en) 1979-05-04
CH649217A5 (de) 1985-05-15
GB2003108B (en) 1982-03-24
FI782501A (fi) 1979-02-26
DK361878A (da) 1979-02-26
ATA612478A (de) 1983-01-15
AT372019B (de) 1983-08-25
NL7808613A (nl) 1979-02-27
FI64899C (fi) 1984-02-10
CA1122077A (fr) 1982-04-20
PH15447A (en) 1983-01-18
IT1098111B (it) 1985-09-07
IE47255B1 (en) 1984-02-08
DK618189A (da) 1989-12-07
ZA784855B (en) 1980-04-30
CH644768A5 (de) 1984-08-31
IT7826961A0 (it) 1978-08-23
DE2836044A1 (de) 1979-03-01
FR2400950B1 (fr) 1983-10-07
DE2836044C2 (fr) 1988-06-23
IL55418A0 (en) 1978-10-31
DK618189D0 (da) 1989-12-07
GB2003108A (en) 1979-03-07
BE869915A (fr) 1979-02-23
ES472800A1 (es) 1979-10-16
FI64899B (fi) 1983-10-31
PT68473A (fr) 1978-09-01
IE781708L (en) 1979-02-25
AU3923678A (en) 1980-02-28

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