FR2611201B1 - Intermediaires de tetrazole et procede de preparation de derives antihypercholesterolemiques du tetrazole - Google Patents
Intermediaires de tetrazole et procede de preparation de derives antihypercholesterolemiques du tetrazoleInfo
- Publication number
- FR2611201B1 FR2611201B1 FR888802212A FR8802212A FR2611201B1 FR 2611201 B1 FR2611201 B1 FR 2611201B1 FR 888802212 A FR888802212 A FR 888802212A FR 8802212 A FR8802212 A FR 8802212A FR 2611201 B1 FR2611201 B1 FR 2611201B1
- Authority
- FR
- France
- Prior art keywords
- tetrazole
- antihypercholesterolem
- derivatives
- preparation
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000003536 tetrazoles Chemical class 0.000 title 2
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1855887A | 1987-02-25 | 1987-02-25 | |
US07/151,512 US4898949A (en) | 1987-02-25 | 1988-02-18 | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2611201A1 FR2611201A1 (fr) | 1988-08-26 |
FR2611201B1 true FR2611201B1 (fr) | 1991-01-11 |
Family
ID=26691250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR888802212A Expired - Fee Related FR2611201B1 (fr) | 1987-02-25 | 1988-02-24 | Intermediaires de tetrazole et procede de preparation de derives antihypercholesterolemiques du tetrazole |
Country Status (27)
Country | Link |
---|---|
US (1) | US4898949A (fr) |
JP (1) | JP2603284B2 (fr) |
KR (1) | KR960007167B1 (fr) |
CN (1) | CN1030077C (fr) |
AT (1) | AT395588B (fr) |
AU (1) | AU610562B2 (fr) |
BE (1) | BE1002115A3 (fr) |
CA (1) | CA1328269C (fr) |
CH (1) | CH678182A5 (fr) |
DE (1) | DE3805789C2 (fr) |
DK (2) | DK97388A (fr) |
ES (1) | ES2009547A6 (fr) |
FI (1) | FI96600C (fr) |
FR (1) | FR2611201B1 (fr) |
GB (1) | GB2202845B (fr) |
GR (1) | GR1000473B (fr) |
HU (3) | HU201534B (fr) |
IE (1) | IE61608B1 (fr) |
IT (1) | IT1216752B (fr) |
LU (1) | LU87143A1 (fr) |
MY (1) | MY102290A (fr) |
NL (1) | NL8800468A (fr) |
NO (1) | NO178432C (fr) |
NZ (1) | NZ223621A (fr) |
PT (1) | PT86821B (fr) |
SE (3) | SE504553C2 (fr) |
YU (1) | YU46781B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870187A (en) * | 1988-08-23 | 1989-09-26 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl compounds |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5260325A (en) * | 1991-08-19 | 1993-11-09 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking tertiary amides |
CA2137049A1 (fr) * | 1993-12-15 | 1995-06-16 | John K. Thottathil | Sels d'acides amines de composes antihypercholesterolemiques a base de tetrazole et leur methode de preparation |
CA2305618C (fr) * | 1997-12-19 | 2004-08-17 | Warner-Lambert Company | Procede de synthese de 1,3-diols |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4160100A (en) * | 1973-03-23 | 1979-07-03 | American Home Products Corporation | Oxamic acid derivatives |
US4013647A (en) * | 1976-03-23 | 1977-03-22 | American Home Products Corporation | Morpholine containing tetrazole-5-carboxamide derivatives |
JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
US4375475A (en) * | 1979-08-17 | 1983-03-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
EP0068038B1 (fr) * | 1981-06-29 | 1985-09-25 | Merck & Co. Inc. | (+)-(4R.6S)-(E)-6-(2-(4'-fluoro-3,3',5-triméthyl-(1,1'-biphényl)-2-yle)éthenyl)-3,4,5,6-tétrahydro-4-hydroxy-2H-pyran-2-one, un procédé pour sa fabrication et une composition pharmaceutique la contenant |
US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
HU204253B (en) * | 1982-11-22 | 1991-12-30 | Sandoz Ag | Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them |
GR81711B (fr) * | 1983-01-24 | 1984-12-12 | Sandoz Ag | |
US5105017A (en) * | 1983-07-18 | 1992-04-14 | Eli Lilly And Company | Leukotriene antagonist intermediates |
CA1327360C (fr) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Analogues oxo d'agents antihypercholesterolemiants ayant les caracteristiques de la mevinoline |
WO1986000307A2 (fr) * | 1984-06-22 | 1986-01-16 | Sandoz Ag | Analogues pyrazole de la mevalonolactone et leurs derives, leurs procedes de preparation et leur utilisation |
US4613610A (en) * | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
US4621099A (en) * | 1985-09-23 | 1986-11-04 | Usv Pharmaceutical Corporation | Polyene compounds useful in the treatment of allergic responses |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
AU601264B2 (en) * | 1987-02-25 | 1990-09-06 | Bristol-Myers Squibb Company | Antihypercholesterolemic tetrazole compounds |
-
1988
- 1988-02-18 US US07/151,512 patent/US4898949A/en not_active Expired - Lifetime
- 1988-02-24 KR KR1019880001915A patent/KR960007167B1/ko not_active IP Right Cessation
- 1988-02-24 GB GB8804281A patent/GB2202845B/en not_active Expired - Fee Related
- 1988-02-24 GR GR880100100A patent/GR1000473B/el not_active IP Right Cessation
- 1988-02-24 IT IT8819526A patent/IT1216752B/it active
- 1988-02-24 CH CH691/88A patent/CH678182A5/de not_active IP Right Cessation
- 1988-02-24 HU HU895133A patent/HU201534B/hu not_active IP Right Cessation
- 1988-02-24 PT PT86821A patent/PT86821B/pt not_active IP Right Cessation
- 1988-02-24 AT AT0046088A patent/AT395588B/de not_active IP Right Cessation
- 1988-02-24 CA CA000559671A patent/CA1328269C/fr not_active Expired - Fee Related
- 1988-02-24 AU AU12132/88A patent/AU610562B2/en not_active Ceased
- 1988-02-24 IE IE50288A patent/IE61608B1/en not_active IP Right Cessation
- 1988-02-24 HU HU895124A patent/HU201533B/hu not_active IP Right Cessation
- 1988-02-24 DE DE3805789A patent/DE3805789C2/de not_active Expired - Fee Related
- 1988-02-24 FI FI880868A patent/FI96600C/fi not_active IP Right Cessation
- 1988-02-24 SE SE8800637A patent/SE504553C2/sv not_active IP Right Cessation
- 1988-02-24 NO NO880802A patent/NO178432C/no not_active IP Right Cessation
- 1988-02-24 ES ES8800533A patent/ES2009547A6/es not_active Expired
- 1988-02-24 HU HU88885A patent/HU201532B/hu not_active IP Right Cessation
- 1988-02-24 DK DK097388A patent/DK97388A/da not_active Application Discontinuation
- 1988-02-24 FR FR888802212A patent/FR2611201B1/fr not_active Expired - Fee Related
- 1988-02-24 MY MYPI88000180A patent/MY102290A/en unknown
- 1988-02-24 NL NL8800468A patent/NL8800468A/nl not_active Application Discontinuation
- 1988-02-24 NZ NZ223621A patent/NZ223621A/en unknown
- 1988-02-24 JP JP63041828A patent/JP2603284B2/ja not_active Expired - Fee Related
- 1988-02-25 LU LU87143A patent/LU87143A1/fr unknown
- 1988-02-25 BE BE8800219A patent/BE1002115A3/fr not_active IP Right Cessation
- 1988-02-25 YU YU36488A patent/YU46781B/sh unknown
-
1992
- 1992-10-20 CN CN92111551A patent/CN1030077C/zh not_active Expired - Fee Related
-
1993
- 1993-03-24 SE SE9300977A patent/SE512485C2/sv not_active IP Right Cessation
- 1993-03-24 SE SE9300976A patent/SE503201C2/sv not_active IP Right Cessation
-
1997
- 1997-10-06 DK DK113897A patent/DK113897A/da not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name | ||
ST | Notification of lapse |
Effective date: 20051031 |