DK113897A - Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser - Google Patents

Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser Download PDF

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Publication number
DK113897A
DK113897A DK113897A DK113897A DK113897A DK 113897 A DK113897 A DK 113897A DK 113897 A DK113897 A DK 113897A DK 113897 A DK113897 A DK 113897A DK 113897 A DK113897 A DK 113897A
Authority
DK
Denmark
Prior art keywords
preparation
tetrazole compounds
antihypercholesterolemic
antihypercholesterolemic tetrazole
compounds
Prior art date
Application number
DK113897A
Other languages
English (en)
Inventor
John J Wright
Sing-Yuen Sit
Neelakantan Balasurbramanian
Peter J Brown
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK113897A publication Critical patent/DK113897A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK113897A 1987-02-25 1997-10-06 Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser DK113897A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1855887A 1987-02-25 1987-02-25
US07/151,512 US4898949A (en) 1987-02-25 1988-02-18 Intermediates for the preparation of antihypercholesterolemic tetrazole compounds

Publications (1)

Publication Number Publication Date
DK113897A true DK113897A (da) 1997-10-06

Family

ID=26691250

Family Applications (2)

Application Number Title Priority Date Filing Date
DK097388A DK97388A (da) 1987-02-25 1988-02-24 Mellemprodukt og fremgangsmaade til fremstilling af antihypercholestrolemiske tetrazolforbindelser
DK113897A DK113897A (da) 1987-02-25 1997-10-06 Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK097388A DK97388A (da) 1987-02-25 1988-02-24 Mellemprodukt og fremgangsmaade til fremstilling af antihypercholestrolemiske tetrazolforbindelser

Country Status (27)

Country Link
US (1) US4898949A (da)
JP (1) JP2603284B2 (da)
KR (1) KR960007167B1 (da)
CN (1) CN1030077C (da)
AT (1) AT395588B (da)
AU (1) AU610562B2 (da)
BE (1) BE1002115A3 (da)
CA (1) CA1328269C (da)
CH (1) CH678182A5 (da)
DE (1) DE3805789C2 (da)
DK (2) DK97388A (da)
ES (1) ES2009547A6 (da)
FI (1) FI96600C (da)
FR (1) FR2611201B1 (da)
GB (1) GB2202845B (da)
GR (1) GR1000473B (da)
HU (3) HU201533B (da)
IE (1) IE61608B1 (da)
IT (1) IT1216752B (da)
LU (1) LU87143A1 (da)
MY (1) MY102290A (da)
NL (1) NL8800468A (da)
NO (1) NO178432C (da)
NZ (1) NZ223621A (da)
PT (1) PT86821B (da)
SE (3) SE504553C2 (da)
YU (1) YU46781B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5260325A (en) * 1991-08-19 1993-11-09 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking tertiary amides
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
BR9813760A (pt) * 1997-12-19 2000-10-03 Warner Lambert Export Limited Processo para a sìntese de 1,3-dióis

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160100A (en) * 1973-03-23 1979-07-03 American Home Products Corporation Oxamic acid derivatives
US4013647A (en) * 1976-03-23 1977-03-22 American Home Products Corporation Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) * 1977-05-24 1978-12-21 Sankyo Co Ltd Mevalonolactone derivatives
IL60751A (en) * 1979-08-17 1985-04-30 Merck & Co Inc 6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them
US4375475A (en) * 1979-08-17 1983-03-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
EP0068038B1 (en) * 1981-06-29 1985-09-25 Merck & Co. Inc. (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
WO1984002131A1 (fr) * 1982-11-22 1984-06-07 Sandoz Ag Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
CA1268473A (en) * 1983-01-24 1990-05-01 Paul L. Anderson Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
WO1986000307A2 (en) * 1984-06-22 1986-01-16 Sandoz Ag Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
US4621099A (en) * 1985-09-23 1986-11-04 Usv Pharmaceutical Corporation Polyene compounds useful in the treatment of allergic responses
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
AU601264B2 (en) * 1987-02-25 1990-09-06 Bristol-Myers Squibb Company Antihypercholesterolemic tetrazole compounds

Also Published As

Publication number Publication date
IT1216752B (it) 1990-03-08
SE504553C2 (sv) 1997-03-03
US4898949A (en) 1990-02-06
HUT47258A (en) 1989-02-28
IE61608B1 (en) 1994-11-16
GR1000473B (el) 1992-07-30
ATA46088A (de) 1992-06-15
SE503201C2 (sv) 1996-04-15
KR960007167B1 (ko) 1996-05-29
FI880868A0 (fi) 1988-02-24
NO178432C (no) 1996-03-27
HU895124D0 (da) 1990-01-28
NL8800468A (nl) 1988-09-16
YU36488A (en) 1990-02-28
SE8800637D0 (sv) 1988-02-24
HU201534B (en) 1990-11-28
SE8800637L (sv) 1988-08-26
GB2202845A (en) 1988-10-05
SE9300977D0 (sv) 1993-03-24
ES2009547A6 (es) 1989-10-01
JP2603284B2 (ja) 1997-04-23
PT86821A (pt) 1988-03-01
BE1002115A3 (fr) 1990-07-10
GB2202845B (en) 1991-05-22
IT8819526A0 (it) 1988-02-24
CA1328269C (en) 1994-04-05
YU46781B (sh) 1994-05-10
FI96600C (fi) 1996-07-25
SE9300976L (da) 1993-03-24
DE3805789A1 (de) 1988-09-15
HU201533B (en) 1990-11-28
NO178432B (no) 1995-12-18
CN1070642A (zh) 1993-04-07
AT395588B (de) 1993-01-25
JPS63290872A (ja) 1988-11-28
DE3805789C2 (de) 2001-05-31
NO880802D0 (no) 1988-02-24
FR2611201A1 (fr) 1988-08-26
CN1030077C (zh) 1995-10-18
DK97388A (da) 1988-08-26
FR2611201B1 (fr) 1991-01-11
HU201532B (en) 1990-11-28
SE9300976D0 (sv) 1993-03-24
SE512485C2 (sv) 2000-03-20
CH678182A5 (da) 1991-08-15
GB8804281D0 (en) 1988-03-23
GR880100100A (en) 1988-12-16
NO880802L (no) 1988-08-26
DK97388D0 (da) 1988-02-24
NZ223621A (en) 1991-06-25
LU87143A1 (fr) 1988-09-20
SE9300977L (da)
MY102290A (en) 1992-05-15
KR880009946A (ko) 1988-10-06
PT86821B (pt) 1992-05-29
FI880868A7 (fi) 1988-08-26
AU1213288A (en) 1988-09-01
IE880502L (en) 1988-08-18
FI96600B (fi) 1996-04-15
AU610562B2 (en) 1991-05-23

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