FR2438659A1 - Procede de preparation du sulfate de vindesine - Google Patents

Procede de preparation du sulfate de vindesine

Info

Publication number
FR2438659A1
FR2438659A1 FR7924841A FR7924841A FR2438659A1 FR 2438659 A1 FR2438659 A1 FR 2438659A1 FR 7924841 A FR7924841 A FR 7924841A FR 7924841 A FR7924841 A FR 7924841A FR 2438659 A1 FR2438659 A1 FR 2438659A1
Authority
FR
France
Prior art keywords
vindesin
preparation
vindesine
concentration
pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7924841A
Other languages
English (en)
Other versions
FR2438659B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2438659A1 publication Critical patent/FR2438659A1/fr
Application granted granted Critical
Publication of FR2438659B1 publication Critical patent/FR2438659B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDE DE PREPARATION DE SULFATE DE VINDESINE, CARACTERISE EN CE QU'IL COMPREND LES ETAPES CONSISTANT A DISSOUDRE DE LA VINDESINE-BASE PRATIQUEMENT PURE DANS DE L'ACETONITRILE OU DE L'ACETONE, A UNE CONCENTRATION D'ENVIRON 1, PUIS A Y AJOUTER UNE MOLE D'ACIDE SULFURIQUE AQUEUX 1N EN AGITANT A UNE VITESSE TELLE QUE L'ON MINIMISE LA FORMATION DE DISULFATE DE VINDESINE, POUR OBTENIR UN PRODUIT QUI EST DU MONOSULFATE DE VINDESINE PRATIQUEMENT PUR. LE COMPOSE AINSI OBTENU A UNE GRANDE STABILITE ET EST FACILE A MANIPULER EN VUE DE SON UTILISATION COMME AGENT PHARMACOLOGIQUE.
FR7924841A 1978-10-10 1979-10-05 Procede de preparation du sulfate de vindesine Granted FR2438659A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94959578A 1978-10-10 1978-10-10

Publications (2)

Publication Number Publication Date
FR2438659A1 true FR2438659A1 (fr) 1980-05-09
FR2438659B1 FR2438659B1 (fr) 1983-03-18

Family

ID=25489302

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7924841A Granted FR2438659A1 (fr) 1978-10-10 1979-10-05 Procede de preparation du sulfate de vindesine

Country Status (32)

Country Link
EP (1) EP0009996B1 (fr)
JP (1) JPS5553295A (fr)
KR (1) KR850000150B1 (fr)
AR (1) AR225153A1 (fr)
AT (1) AT370422B (fr)
AU (1) AU525702B2 (fr)
BE (1) BE879213A (fr)
BG (1) BG34763A3 (fr)
CA (1) CA1114817A (fr)
CH (2) CH645120A5 (fr)
CS (1) CS235503B2 (fr)
DD (1) DD146461A5 (fr)
DE (1) DE2964913D1 (fr)
DK (1) DK146823C (fr)
EG (1) EG14140A (fr)
ES (1) ES484827A1 (fr)
FI (1) FI70223C (fr)
FR (1) FR2438659A1 (fr)
GB (1) GB2031893B (fr)
GR (1) GR72394B (fr)
HU (1) HU180744B (fr)
IE (1) IE48958B1 (fr)
IL (1) IL58390A (fr)
LU (1) LU81763A1 (fr)
MY (1) MY8500569A (fr)
NZ (1) NZ191744A (fr)
PH (1) PH16092A (fr)
PL (1) PL117678B1 (fr)
PT (1) PT70269A (fr)
RO (1) RO77380A (fr)
YU (1) YU241179A (fr)
ZA (1) ZA795268B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558053A (en) * 1983-12-21 1985-12-10 Eli Lilly And Company Naphthalene-1,5-disulfonate salts of dimeric indole-dihydroindole alkaloids
CN112592357B (zh) * 2020-12-22 2022-03-22 海南长春花药业有限公司 一种硫酸长春地辛的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2297043A1 (fr) * 1975-01-09 1976-08-06 Lilly Co Eli Nouveaux derives amide des vinblastine, leurosidine, leurocristine et alcaloides dimeres apparentes
FR2316950A1 (fr) * 1975-07-10 1977-02-04 Lely Nv C Van Der Nouveaux derives anhydro d'alcaloides de vinca
FR2364220A1 (fr) * 1976-09-08 1978-04-07 Lilly Co Eli Nouveaux derives amide de la vlb, de la leurosidine, de la leurocristine et d'autres alcaloides apparentes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2297043A1 (fr) * 1975-01-09 1976-08-06 Lilly Co Eli Nouveaux derives amide des vinblastine, leurosidine, leurocristine et alcaloides dimeres apparentes
FR2316950A1 (fr) * 1975-07-10 1977-02-04 Lely Nv C Van Der Nouveaux derives anhydro d'alcaloides de vinca
FR2364220A1 (fr) * 1976-09-08 1978-04-07 Lilly Co Eli Nouveaux derives amide de la vlb, de la leurosidine, de la leurocristine et d'autres alcaloides apparentes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/78 *

Also Published As

Publication number Publication date
KR830001282A (ko) 1983-04-30
CH645120A5 (fr) 1984-09-14
GB2031893A (en) 1980-04-30
FR2438659B1 (fr) 1983-03-18
AT370422B (de) 1983-03-25
FI793065A (fi) 1980-04-11
KR850000150B1 (ko) 1985-02-28
FI70223B (fi) 1986-02-28
IE48958B1 (en) 1985-06-26
RO77380A (fr) 1981-11-04
DE2964913D1 (en) 1983-03-31
GR72394B (fr) 1983-11-01
CS235503B2 (en) 1985-05-15
AR225153A1 (es) 1982-02-26
DD146461A5 (de) 1981-02-11
IE791914L (en) 1980-04-10
GB2031893B (en) 1983-03-30
DK146823B (da) 1984-01-16
AU5142779A (en) 1980-04-17
YU241179A (en) 1983-01-21
DK422979A (da) 1980-04-11
PH16092A (en) 1983-06-20
PL218756A1 (fr) 1980-06-16
MY8500569A (en) 1985-12-31
BG34763A3 (en) 1983-11-15
IL58390A0 (en) 1980-01-31
LU81763A1 (fr) 1980-01-24
FI70223C (fi) 1986-09-15
CH649301A5 (fr) 1985-05-15
EP0009996B1 (fr) 1983-02-23
EG14140A (en) 1983-09-30
JPS628119B2 (fr) 1987-02-20
AU525702B2 (en) 1982-11-25
DK146823C (da) 1984-07-02
IL58390A (en) 1982-07-30
PL117678B1 (en) 1981-08-31
ATA658279A (de) 1982-08-15
NZ191744A (en) 1981-05-29
ES484827A1 (es) 1980-10-01
BE879213A (fr) 1980-04-08
HU180744B (en) 1983-04-29
JPS5553295A (en) 1980-04-18
EP0009996A1 (fr) 1980-04-16
CA1114817A (fr) 1981-12-22
ZA795268B (en) 1981-05-27
PT70269A (de) 1979-11-01

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