ES484827A1 - Un procedimiento para la preparacion de sulfato de vindesina - Google Patents
Un procedimiento para la preparacion de sulfato de vindesinaInfo
- Publication number
- ES484827A1 ES484827A1 ES484827A ES484827A ES484827A1 ES 484827 A1 ES484827 A1 ES 484827A1 ES 484827 A ES484827 A ES 484827A ES 484827 A ES484827 A ES 484827A ES 484827 A1 ES484827 A1 ES 484827A1
- Authority
- ES
- Spain
- Prior art keywords
- vindesine
- preparation
- monosulfate
- sulfuric acid
- vindesine monosulfate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
Un procedimiento para la preparación de sulfato de vindesina, que comprende: a) disolver vindesina base sustancialmente pura en acetonitrilo o acetona, a una concentración de aproximadamente 1% y b)hacer reaccionar la disolución de la etapa anterior, en una o dos operaciones con ácido sulfúrico acuoso 1N con agitación, a una velocidad tal que se minimiza la formación de disulfato de vindesina, para originar el monosulfato de vindesina sustancialmente puro.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94959578A | 1978-10-10 | 1978-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484827A1 true ES484827A1 (es) | 1980-10-01 |
Family
ID=25489302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484827A Expired ES484827A1 (es) | 1978-10-10 | 1979-10-08 | Un procedimiento para la preparacion de sulfato de vindesina |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0009996B1 (es) |
| JP (1) | JPS5553295A (es) |
| KR (1) | KR850000150B1 (es) |
| AR (1) | AR225153A1 (es) |
| AT (1) | AT370422B (es) |
| AU (1) | AU525702B2 (es) |
| BE (1) | BE879213A (es) |
| BG (1) | BG34763A3 (es) |
| CA (1) | CA1114817A (es) |
| CH (2) | CH645120A5 (es) |
| CS (1) | CS235503B2 (es) |
| DD (1) | DD146461A5 (es) |
| DE (1) | DE2964913D1 (es) |
| DK (1) | DK146823C (es) |
| EG (1) | EG14140A (es) |
| ES (1) | ES484827A1 (es) |
| FI (1) | FI70223C (es) |
| FR (1) | FR2438659A1 (es) |
| GB (1) | GB2031893B (es) |
| GR (1) | GR72394B (es) |
| HU (1) | HU180744B (es) |
| IE (1) | IE48958B1 (es) |
| IL (1) | IL58390A (es) |
| LU (1) | LU81763A1 (es) |
| MY (1) | MY8500569A (es) |
| NZ (1) | NZ191744A (es) |
| PH (1) | PH16092A (es) |
| PL (1) | PL117678B1 (es) |
| PT (1) | PT70269A (es) |
| RO (1) | RO77380A (es) |
| YU (1) | YU241179A (es) |
| ZA (1) | ZA795268B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4558053A (en) * | 1983-12-21 | 1985-12-10 | Eli Lilly And Company | Naphthalene-1,5-disulfonate salts of dimeric indole-dihydroindole alkaloids |
| CN112592357B (zh) * | 2020-12-22 | 2022-03-22 | 海南长春花药业有限公司 | 一种硫酸长春地辛的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
| US4029663A (en) * | 1975-07-10 | 1977-06-14 | Eli Lilly And Company | Dimeric anhydro-vinca derivatives |
| GR69783B (es) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli |
-
1979
- 1979-10-02 AR AR278306A patent/AR225153A1/es active
- 1979-10-03 FI FI793065A patent/FI70223C/fi not_active IP Right Cessation
- 1979-10-03 PT PT70269A patent/PT70269A/pt unknown
- 1979-10-03 AU AU51427/79A patent/AU525702B2/en not_active Expired
- 1979-10-03 CS CS796720A patent/CS235503B2/cs unknown
- 1979-10-03 ZA ZA00795268A patent/ZA795268B/xx unknown
- 1979-10-03 NZ NZ191744A patent/NZ191744A/xx unknown
- 1979-10-03 YU YU02411/79A patent/YU241179A/xx unknown
- 1979-10-04 CA CA336,959A patent/CA1114817A/en not_active Expired
- 1979-10-04 IL IL58390A patent/IL58390A/xx unknown
- 1979-10-04 JP JP12879579A patent/JPS5553295A/ja active Granted
- 1979-10-05 BE BE1/9554A patent/BE879213A/fr not_active IP Right Cessation
- 1979-10-05 FR FR7924841A patent/FR2438659A1/fr active Granted
- 1979-10-05 PL PL1979218756A patent/PL117678B1/pl unknown
- 1979-10-06 RO RO7998873A patent/RO77380A/ro unknown
- 1979-10-08 GR GR60215A patent/GR72394B/el unknown
- 1979-10-08 CH CH904479A patent/CH645120A5/fr not_active IP Right Cessation
- 1979-10-08 CH CH691/84A patent/CH649301A5/fr not_active IP Right Cessation
- 1979-10-08 BG BG7945074A patent/BG34763A3/xx unknown
- 1979-10-08 ES ES484827A patent/ES484827A1/es not_active Expired
- 1979-10-08 LU LU81763A patent/LU81763A1/fr unknown
- 1979-10-09 HU HU79EI881A patent/HU180744B/hu unknown
- 1979-10-09 IE IE1914/79A patent/IE48958B1/en not_active IP Right Cessation
- 1979-10-09 GB GB7935062A patent/GB2031893B/en not_active Expired
- 1979-10-09 EG EG590/79A patent/EG14140A/xx active
- 1979-10-09 DK DK422979A patent/DK146823C/da not_active IP Right Cessation
- 1979-10-09 DE DE7979302152T patent/DE2964913D1/de not_active Expired
- 1979-10-09 AT AT0658279A patent/AT370422B/de not_active IP Right Cessation
- 1979-10-09 EP EP79302152A patent/EP0009996B1/en not_active Expired
- 1979-10-10 KR KR7903467A patent/KR850000150B1/ko active
- 1979-10-10 DD DD79216158A patent/DD146461A5/de unknown
-
1981
- 1981-02-03 PH PH25176A patent/PH16092A/en unknown
-
1985
- 1985-12-30 MY MY569/85A patent/MY8500569A/xx unknown
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