FR2419723A1 - Sels d'ornithine et d'arginine d'acides cetoniques a chaine ramifiee, et leur utilisation pour le traitement des affections hepatiques et renales - Google Patents

Sels d'ornithine et d'arginine d'acides cetoniques a chaine ramifiee, et leur utilisation pour le traitement des affections hepatiques et renales

Info

Publication number
FR2419723A1
FR2419723A1 FR7906533A FR7906533A FR2419723A1 FR 2419723 A1 FR2419723 A1 FR 2419723A1 FR 7906533 A FR7906533 A FR 7906533A FR 7906533 A FR7906533 A FR 7906533A FR 2419723 A1 FR2419723 A1 FR 2419723A1
Authority
FR
France
Prior art keywords
treatment
ornithine
hepatic
branched chain
arginine salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7906533A
Other languages
English (en)
French (fr)
Other versions
FR2419723B1 (OSRAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of FR2419723A1 publication Critical patent/FR2419723A1/fr
Application granted granted Critical
Publication of FR2419723B1 publication Critical patent/FR2419723B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7906533A 1978-03-17 1979-03-14 Sels d'ornithine et d'arginine d'acides cetoniques a chaine ramifiee, et leur utilisation pour le traitement des affections hepatiques et renales Granted FR2419723A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/887,570 US4228099A (en) 1978-03-17 1978-03-17 Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders

Publications (2)

Publication Number Publication Date
FR2419723A1 true FR2419723A1 (fr) 1979-10-12
FR2419723B1 FR2419723B1 (OSRAM) 1982-10-29

Family

ID=25391422

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7906533A Granted FR2419723A1 (fr) 1978-03-17 1979-03-14 Sels d'ornithine et d'arginine d'acides cetoniques a chaine ramifiee, et leur utilisation pour le traitement des affections hepatiques et renales

Country Status (17)

Country Link
US (1) US4228099A (OSRAM)
JP (1) JPS5838421B2 (OSRAM)
AU (1) AU517505B2 (OSRAM)
BE (1) BE874900A (OSRAM)
CA (1) CA1115729A (OSRAM)
DE (1) DE2910221A1 (OSRAM)
DK (1) DK153542C (OSRAM)
ES (1) ES478710A1 (OSRAM)
FI (1) FI72118C (OSRAM)
FR (1) FR2419723A1 (OSRAM)
GB (1) GB2017094B (OSRAM)
IE (1) IE48336B1 (OSRAM)
IT (1) IT1202904B (OSRAM)
LU (1) LU81057A1 (OSRAM)
NL (1) NL7902136A (OSRAM)
NO (1) NO151119C (OSRAM)
SE (1) SE446724B (OSRAM)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2454434A1 (fr) * 1979-04-18 1980-11-14 Univ Johns Hopkins Sels mixtes d'acides amines essentiels ou semi-essentiels et de produits analogues, exempts d'azote, de ces acides, et leur utilisation dans le traitement de desordres renaux et hepatiques
EP0295166A1 (fr) * 1987-05-27 1988-12-14 Synthelabo Compositions pharmaceutiques contenant un mélange de sels de cétoacides et d'amino-acides
US4908214A (en) * 1987-07-23 1990-03-13 Synthelabo Pharmaceutical tablet for the treatment of uraemia
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US4752619A (en) * 1985-12-23 1988-06-21 The Johns Hopkins University Nutritional supplement for treatment of uremia
US4744990A (en) * 1986-09-25 1988-05-17 W. R. Grace & Co. Hydantoins as animal food supplements
US4871552A (en) * 1986-09-25 1989-10-03 W. R. Grace & Co.-Conn. Hydantoins as animal food supplements
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
SE462463B (sv) * 1988-12-02 1990-07-02 Decken Alexandra V D Livs- och fodermedel innehaallande ketosyror
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
US5210098A (en) * 1990-09-21 1993-05-11 Regents Of The University Of Minnesota Use of pyruvate to treat acute renal failure
US5234696A (en) * 1991-12-27 1993-08-10 Abbott Laboratories Method of producing tablets, tablets produced thereby, and method of treatment using same
ATE235166T1 (de) 1994-10-07 2003-04-15 Firmenich & Cie Aromazusammensetzungen und aromatisierungsverfahren
US5591736A (en) * 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
EP1377339A4 (en) * 2001-04-04 2006-05-31 Critical Therapeutics Inc PROCEDURE FOR PREVENTING AKUTER NIERENINSUFFIZIENZ
JP4778913B2 (ja) * 2004-11-15 2011-09-21 協和発酵バイオ株式会社 Ｌ−オルニチン結晶およびその製造方法
ES2448549T3 (es) * 2004-11-26 2014-03-14 Ucl Business Plc Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para tratar encefalopatía hepática
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
ES2652187T3 (es) 2009-04-03 2018-01-31 Ocera Therapeutics, Inc. Fenilacetato de l-ornitina y métodos para elaborar el mismo
EP2440200B8 (en) 2009-06-08 2014-10-15 UCL Business PLC Treatment of portal hypertension using l-ornithine phenylacetate
EP2625162B1 (en) 2010-10-06 2019-03-13 Ocera Therapeutics, Inc. Methods of making l-ornithine phenyl acetate
KR102487376B1 (ko) 2014-11-24 2023-01-10 유씨엘 비즈니스 리미티드 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료
JP6990170B2 (ja) 2015-08-18 2022-01-12 オセラ セラピューティクス， インコーポレイテッド Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防
CN106674057A (zh) * 2015-11-09 2017-05-17 江西乐维生物药业有限公司 L-精氨酸a-酮基异己酸盐的制备方法
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
WO2017090007A1 (en) * 2015-11-29 2017-06-01 Rao M Surya Compositions and methods for the treatment of urea cycle disorders and hepatic diseases
CN110740988A (zh) 2017-05-11 2020-01-31 欧塞拉治疗有限公司 制备l-鸟氨酸苯乙酸盐的方法
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
EP3716966A4 (en) 2017-11-29 2021-08-18 Hull, Edgar, L., Jr. ALPHA-KETO ACID COMPOSITIONS FOR THE TREATMENT OF HYPOALBUMINEMIA
US12109254B2 (en) 2017-11-29 2024-10-08 Edgar Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA814483A (en) * 1969-06-03 Abe Kyuji L-ornithine-l-aspartate
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
FR1432756A (fr) 1965-02-11 1966-03-25 D Opochimiotherapie Lab Pyruvates d'amino-acides et leur procédé de préparation
US3441650A (en) * 1965-07-23 1969-04-29 Lab Jacques Logeais Sa Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate
DE2335215B2 (de) * 1972-07-13 1979-04-05 The Johns Hopkins University, Baltimore, Md. (V.St.A.) Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen
US4100293A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2454434A1 (fr) * 1979-04-18 1980-11-14 Univ Johns Hopkins Sels mixtes d'acides amines essentiels ou semi-essentiels et de produits analogues, exempts d'azote, de ces acides, et leur utilisation dans le traitement de desordres renaux et hepatiques
EP0295166A1 (fr) * 1987-05-27 1988-12-14 Synthelabo Compositions pharmaceutiques contenant un mélange de sels de cétoacides et d'amino-acides
US4908214A (en) * 1987-07-23 1990-03-13 Synthelabo Pharmaceutical tablet for the treatment of uraemia
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin

Also Published As

Publication number Publication date
DE2910221C2 (OSRAM) 1988-04-28
FR2419723B1 (OSRAM) 1982-10-29
US4228099A (en) 1980-10-14
JPS5838421B2 (ja) 1983-08-23
BE874900A (fr) 1979-07-16
AU4515479A (en) 1979-09-20
FI790901A7 (fi) 1979-09-18
CA1115729A (en) 1982-01-05
IE48336B1 (en) 1984-12-12
NO790903L (no) 1979-09-18
FI72118B (fi) 1986-12-31
NO151119C (no) 1985-02-13
LU81057A1 (fr) 1979-09-07
DK153542C (da) 1988-12-05
DK153542B (da) 1988-07-25
SE7902401L (sv) 1979-10-16
SE446724B (sv) 1986-10-06
NL7902136A (nl) 1979-09-19
DK110879A (da) 1979-09-18
ES478710A1 (es) 1980-01-16
NO151119B (no) 1984-11-05
IT7921071A0 (it) 1979-03-16
IT1202904B (it) 1989-02-15
GB2017094B (en) 1982-07-07
GB2017094A (en) 1979-10-03
JPS54163518A (en) 1979-12-26
IE790993L (en) 1979-09-17
DE2910221A1 (de) 1979-09-20
FI72118C (fi) 1987-04-13
AU517505B2 (en) 1981-08-06

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