DK0514357T3 - Anvendelse af estere af acyl-L-carnitiner med gamma-hydroxysmørsyre til fremstilling af farmaceutiske præparater til behandling af hepatopatier - Google Patents

Anvendelse af estere af acyl-L-carnitiner med gamma-hydroxysmørsyre til fremstilling af farmaceutiske præparater til behandling af hepatopatier

Info

Publication number
DK0514357T3
DK0514357T3 DK92830220.7T DK92830220T DK0514357T3 DK 0514357 T3 DK0514357 T3 DK 0514357T3 DK 92830220 T DK92830220 T DK 92830220T DK 0514357 T3 DK0514357 T3 DK 0514357T3
Authority
DK
Denmark
Prior art keywords
hepatopathies
gamma
esters
acyl
hydroxybutyric acid
Prior art date
Application number
DK92830220.7T
Other languages
English (en)
Inventor
Fabio Zezza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0514357T3 publication Critical patent/DK0514357T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92830220.7T 1991-05-15 1992-05-12 Anvendelse af estere af acyl-L-carnitiner med gamma-hydroxysmørsyre til fremstilling af farmaceutiske præparater til behandling af hepatopatier DK0514357T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910327A IT1248321B (it) 1991-05-15 1991-05-15 Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie

Publications (1)

Publication Number Publication Date
DK0514357T3 true DK0514357T3 (da) 1996-02-26

Family

ID=11400141

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92830220.7T DK0514357T3 (da) 1991-05-15 1992-05-12 Anvendelse af estere af acyl-L-carnitiner med gamma-hydroxysmørsyre til fremstilling af farmaceutiske præparater til behandling af hepatopatier

Country Status (8)

Country Link
US (1) US5246967A (da)
EP (1) EP0514357B1 (da)
JP (1) JP3406614B2 (da)
AT (1) ATE132746T1 (da)
DE (1) DE69207479T2 (da)
DK (1) DK0514357T3 (da)
HK (1) HK1005848A1 (da)
IT (1) IT1248321B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261432B (it) * 1993-03-26 1996-05-23 Sigma Tau Ind Farmaceuti Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261485B (it) * 1993-06-24 1996-05-23 Sigma Tau Ind Farmaceuti Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze.
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1277898B1 (it) * 1995-08-03 1997-11-12 Mendes Srl Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
IT1306129B1 (it) * 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
EP3609485A4 (en) * 2017-04-11 2021-01-06 John K. Thottathil NEW PRODUCTS OF GAMMA-HYDROXYBUTYRATE (GHB) BASED ON ALPHA-HYDROXY CARBOXYLIC ACID AND DERIVATIVES AND OTHER FAT AND THEIR USES
GB201710229D0 (en) * 2017-06-27 2017-08-09 Tdeltas Ltd Compounds for new use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
DE3166142D1 (en) * 1980-06-09 1984-10-25 Leopold & Co Chem Pharm Infusion solution for the protection of the liver and the improvement of its functioning, and process for its production
IT1208753B (it) * 1986-07-02 1989-07-10 Sigma Tau Ind Farmaceuti L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Also Published As

Publication number Publication date
EP0514357B1 (en) 1996-01-10
ITRM910327A0 (it) 1991-05-15
HK1005848A1 (en) 1999-01-29
US5246967A (en) 1993-09-21
JP3406614B2 (ja) 2003-05-12
DE69207479D1 (de) 1996-02-22
DE69207479T2 (de) 1996-05-23
ITRM910327A1 (it) 1992-11-15
EP0514357A1 (en) 1992-11-19
ATE132746T1 (de) 1996-01-15
JPH05163141A (ja) 1993-06-29
IT1248321B (it) 1995-01-05

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