ATE157348T1 - Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE157348T1
ATE157348T1 AT93830083T AT93830083T ATE157348T1 AT E157348 T1 ATE157348 T1 AT E157348T1 AT 93830083 T AT93830083 T AT 93830083T AT 93830083 T AT93830083 T AT 93830083T AT E157348 T1 ATE157348 T1 AT E157348T1
Authority
AT
Austria
Prior art keywords
carnitine
acyl
esters
gastrointestinal tract
selective
Prior art date
Application number
AT93830083T
Other languages
English (en)
Inventor
Nazareno Scafetta
Mose Santaniello
Maria Ornella Tinti
Domenico Misiti
Maria Antonietta Stasi
Loredana Vesci
Nerina Corsico
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE157348T1 publication Critical patent/ATE157348T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93830083T 1992-03-02 1993-03-01 Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen ATE157348T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920138A IT1258370B (it) 1992-03-02 1992-03-02 Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number Publication Date
ATE157348T1 true ATE157348T1 (de) 1997-09-15

Family

ID=11400749

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93830083T ATE157348T1 (de) 1992-03-02 1993-03-01 Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen

Country Status (8)

Country Link
EP (1) EP0559625B1 (de)
AT (1) ATE157348T1 (de)
DE (1) DE69313325T2 (de)
DK (1) DK0559625T3 (de)
ES (1) ES2106998T3 (de)
GR (1) GR3025093T3 (de)
HK (1) HK1006368A1 (de)
IT (1) IT1258370B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
AU718308B2 (en) * 1996-05-31 2000-04-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
IT1284661B1 (it) * 1996-06-06 1998-05-21 Sigma Tau Ind Farmaceuti Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.
IT1299172B1 (it) * 1998-05-06 2000-02-29 Sigma Tau Ind Farmaceuti Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
IT1306129B1 (it) * 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
AU2007214359B2 (en) * 1999-04-13 2009-02-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
US11103588B2 (en) * 2017-06-06 2021-08-31 Wayne State University Methods and compositions relating to carnitine-derived materials
CN111601512B (zh) * 2019-03-06 2023-11-17 彭险峰 γ-季铵基丁酸酯类化合物在制备动物饲料添加剂中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.

Also Published As

Publication number Publication date
DE69313325T2 (de) 1998-01-29
IT1258370B (it) 1996-02-26
ITRM920138A0 (it) 1992-03-02
DE69313325D1 (de) 1997-10-02
EP0559625A2 (de) 1993-09-08
HK1006368A1 (en) 1999-02-26
EP0559625A3 (en) 1993-12-01
EP0559625B1 (de) 1997-08-27
GR3025093T3 (en) 1998-01-30
ITRM920138A1 (it) 1993-09-02
ES2106998T3 (es) 1997-11-16
DK0559625T3 (da) 1997-12-29

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Legal Events

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UEP Publication of translation of european patent specification