IT1261485B - Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze. - Google Patents
Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze.Info
- Publication number
- IT1261485B IT1261485B ITRM930412A ITRM930412A IT1261485B IT 1261485 B IT1261485 B IT 1261485B IT RM930412 A ITRM930412 A IT RM930412A IT RM930412 A ITRM930412 A IT RM930412A IT 1261485 B IT1261485 B IT 1261485B
- Authority
- IT
- Italy
- Prior art keywords
- treatment
- carnitine
- hydroxybutirrate
- acil
- range
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- 206010013663 drug dependence Diseases 0.000 title 1
- 208000011117 substance-related disease Diseases 0.000 title 1
- -1 acyl L-carnitine esters Chemical class 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 235000019788 craving Nutrition 0.000 abstract 1
- 230000003533 narcotic effect Effects 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Viene descritto l'uso di esteri di acil L-carnitine con l'acido gamma-idrossibutirrico in cui l'acile è preferibilmente acetile, propionile, n-butirrile, isobutirrile, valerile e isovalerile, per produrre un farmaco per il trattamento delle tossicodipendenze atto a sopprimere nei drogati i sintomi dell'astinenza e il desiderio incoercibile ("craving") di autosomministrazione di sostanze stupefacenti.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM930412A IT1261485B (it) | 1993-06-24 | 1993-06-24 | Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze. |
| EP94830299A EP0630648B1 (en) | 1993-06-24 | 1994-06-20 | Use of acyl L-carnitine gamma-hydroxybutyrate for the manufacture of a medicamentfor the treatment of drug addiction |
| AT94830299T ATE161719T1 (de) | 1993-06-24 | 1994-06-20 | Verwendung van acyl-l-carnitin-gamma- hydroxybutyraten zur herstellung eines arzneimittels zur behandlung der drogenabhängigkeit |
| DK94830299T DK0630648T3 (da) | 1993-06-24 | 1994-06-20 | Anvendelse af acyl-L-carnitin-gamma-hydroxybutyrat til fremstilling af et medikament til behandling af stofafhængighed |
| DE69407668T DE69407668T2 (de) | 1993-06-24 | 1994-06-20 | Verwendung van Acyl-L-Carnitin-gamma-hydroxybutyraten zur Herstellung eines Arzneimittels zur Behandlung der Drogenabhängigkeit |
| ES94830299T ES2111890T3 (es) | 1993-06-24 | 1994-06-20 | Empleo del acil l-carnitina gamma-hidroxibutirato para el tratamiento de la drogadiccion. |
| JP6141570A JPH0733654A (ja) | 1993-06-24 | 1994-06-23 | 麻薬常用癖の処置用薬剤 |
| GR980400635T GR3026443T3 (en) | 1993-06-24 | 1998-03-24 | Use of acyl L-carnitine gamma-hydroxybutyrate for the treatment of drug addiction. |
| HK98104928A HK1005902A1 (en) | 1993-06-24 | 1998-06-05 | Use of acyl l-carnitine gamma-hydroxybutyrate for the manufacture of a medicamentfor the treatment of drug addiction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM930412A IT1261485B (it) | 1993-06-24 | 1993-06-24 | Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM930412A0 ITRM930412A0 (it) | 1993-06-24 |
| ITRM930412A1 ITRM930412A1 (it) | 1994-12-24 |
| IT1261485B true IT1261485B (it) | 1996-05-23 |
Family
ID=11401821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM930412A IT1261485B (it) | 1993-06-24 | 1993-06-24 | Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0630648B1 (it) |
| JP (1) | JPH0733654A (it) |
| AT (1) | ATE161719T1 (it) |
| DE (1) | DE69407668T2 (it) |
| DK (1) | DK0630648T3 (it) |
| ES (1) | ES2111890T3 (it) |
| GR (1) | GR3026443T3 (it) |
| HK (1) | HK1005902A1 (it) |
| IT (1) | IT1261485B (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7015200B2 (en) | 2000-09-22 | 2006-03-21 | Orphan Medical, Inc. | Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers |
| WO2021211540A1 (en) * | 2020-04-14 | 2021-10-21 | The Regents Of The University Of California | Diagnosis and treatment of addiction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1217783B (it) * | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
-
1993
- 1993-06-24 IT ITRM930412A patent/IT1261485B/it active IP Right Grant
-
1994
- 1994-06-20 EP EP94830299A patent/EP0630648B1/en not_active Expired - Lifetime
- 1994-06-20 ES ES94830299T patent/ES2111890T3/es not_active Expired - Lifetime
- 1994-06-20 DE DE69407668T patent/DE69407668T2/de not_active Expired - Fee Related
- 1994-06-20 DK DK94830299T patent/DK0630648T3/da active
- 1994-06-20 AT AT94830299T patent/ATE161719T1/de not_active IP Right Cessation
- 1994-06-23 JP JP6141570A patent/JPH0733654A/ja active Pending
-
1998
- 1998-03-24 GR GR980400635T patent/GR3026443T3/el unknown
- 1998-06-05 HK HK98104928A patent/HK1005902A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE161719T1 (de) | 1998-01-15 |
| DK0630648T3 (da) | 1998-09-07 |
| DE69407668T2 (de) | 1998-04-16 |
| DE69407668D1 (de) | 1998-02-12 |
| JPH0733654A (ja) | 1995-02-03 |
| ES2111890T3 (es) | 1998-03-16 |
| HK1005902A1 (en) | 1999-01-29 |
| EP0630648A1 (en) | 1994-12-28 |
| ITRM930412A1 (it) | 1994-12-24 |
| ITRM930412A0 (it) | 1993-06-24 |
| EP0630648B1 (en) | 1998-01-07 |
| GR3026443T3 (en) | 1998-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960524 |