FR2388556A1 - Application therapeutique de l'acetyl-carnitine-d,1 et d'autres derives acyliques de la carnitine-d,1 - Google Patents
Application therapeutique de l'acetyl-carnitine-d,1 et d'autres derives acyliques de la carnitine-d,1Info
- Publication number
- FR2388556A1 FR2388556A1 FR7811863A FR7811863A FR2388556A1 FR 2388556 A1 FR2388556 A1 FR 2388556A1 FR 7811863 A FR7811863 A FR 7811863A FR 7811863 A FR7811863 A FR 7811863A FR 2388556 A1 FR2388556 A1 FR 2388556A1
- Authority
- FR
- France
- Prior art keywords
- carnitine
- acetyl
- derivatives
- therapeutic application
- humans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Certaines méthodes d'utilisation de dérivés acyliques de la carnitine-d,1 sont proposées pour le traitement de l'anoxie myocardique, de l'ischémie, de syndromes arythmiques et d'insuffisance cardiaque, tant chez l'animal que chez l'homme. L'acétyl-carnitine-d,1 et ses sels acceptables pharmaceutiquement, par exemple son chlorhydrate, représentent une amélioration remarquable dans le traitement de la fatigue du coeur chez l'animal et chez l'homme, ainsi que dans des situations pathologiques caractérisées par des troubles du rythme cardiaque. D'autres dérivés très efficaces de la carnitine sont : la propionyl-carnitine-d,1, la butyryl-carnitine-d,1, l'hydroxybutyryl-carnitine-d,1, l'hexanoyl-carnitine-d,1, l'octanoyl-carnitine-d,1, la décanoyl-carnitine-d,1, la palmitoyl-carnitine-d,1, la stéaroyl-carnitine-d,1 et l'acétoacétyl-carnitine-d,1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4918077A IT1126725B (it) | 1977-04-29 | 1977-04-29 | Applicazione della acetil-d i-carni tina nella terapia delle affezioni cardiache |
IT4789878A IT1155813B (it) | 1978-02-03 | 1978-02-03 | Nuova applicazione terapeutica dell'acetil-d i-carnitina e di altri derivati acilati della d- i-carnitina |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2388556A1 true FR2388556A1 (fr) | 1978-11-24 |
FR2388556B1 FR2388556B1 (fr) | 1981-05-29 |
Family
ID=26329243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7811863A Granted FR2388556A1 (fr) | 1977-04-29 | 1978-04-21 | Application therapeutique de l'acetyl-carnitine-d,1 et d'autres derives acyliques de la carnitine-d,1 |
Country Status (11)
Country | Link |
---|---|
US (1) | US4194006A (fr) |
JP (1) | JPS53136523A (fr) |
AU (1) | AU518617B2 (fr) |
BE (1) | BE866568A (fr) |
CH (1) | CH636268A5 (fr) |
DE (1) | DE2817358A1 (fr) |
FR (1) | FR2388556A1 (fr) |
GB (1) | GB1596491A (fr) |
IE (1) | IE46703B1 (fr) |
KE (1) | KE3223A (fr) |
NL (1) | NL188078C (fr) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2414914A1 (fr) * | 1978-01-18 | 1979-08-17 | Sigma Tau Ind Farmaceuti | Utilisations therapeutiques nouvelles de l'acetyl-1-carnitine et d'autres derives acyles de la 1-carnitine |
FR2425855A1 (fr) * | 1978-05-15 | 1979-12-14 | Cavazza Claudio | Application des acyl-carnitines a un procede therapeutique de traitement de patients uremiques chroniques en traitement hemodialytique periodique et composition liquide de dialyse pour la mise en oeuvre d'un tel procede |
FR2448348A1 (fr) * | 1979-02-12 | 1980-09-05 | Cavazza Claudio | Composition pharmaceutique comprenant une acyl-carnitine pour le traitement du metabolisme cerebral perturbe |
FR2448347A1 (fr) * | 1979-02-12 | 1980-09-05 | Cavazza Claudio | Composition pharmaceutique comprenant une acyl-carnitine pour le traitement des maladies vasculaires peripheriques |
US4439438A (en) * | 1979-04-23 | 1984-03-27 | Claudio Cavazza | Esters of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such esters |
EP0162764A1 (fr) * | 1984-05-02 | 1985-11-27 | Merck & Co. Inc. | Composition et méthode pour améliorer la résorption d'un médicament dans le faisceau gastro-intestinal employant des acylcarnitines |
EP0442850A1 (fr) * | 1990-02-12 | 1991-08-21 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Esters d'acyl L-carnitines avec l'acide gamma-hydroxybutyrique et compositions pharmaceutiques les contenant pour inhiber la dégénération neuronale et pour le traitement du coma |
WO2000000183A2 (fr) * | 1998-06-30 | 2000-01-06 | Sigma-Tau Healthscience S.P.A. | Composition antioxydante, cytostatique et a energie durable, ameliorant l'utilisation metabolique du glucose |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2903579A1 (de) * | 1978-02-03 | 1979-08-09 | Sigma Tau Ind Farmaceuti | Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel |
IT1156840B (it) * | 1978-06-27 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Acil derivati della carnitina |
IT1120033B (it) * | 1979-10-05 | 1986-03-19 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale |
IT1145362B (it) * | 1980-03-06 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
IT1145371B (it) * | 1980-05-30 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono |
IT1147079B (it) * | 1980-05-30 | 1986-11-19 | Sigma Tau Ind Farmacuetiche Ri | Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono |
IT1143214B (it) * | 1981-07-09 | 1986-10-22 | Sigma Tau Ind Farmaceuti | Acil derivato della carnitina quale immunomodulatore |
IT1157238B (it) * | 1982-10-29 | 1987-02-11 | Sigma Tau Ind Farmaceuti | Impiego di 1-carnitina per migliorare i paramenti biochimici e comportamentali dell'eta' senile |
IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
US5550289A (en) * | 1985-01-07 | 1996-08-27 | Syntex (U.S.A.) Inc. | N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
CH676930A5 (fr) * | 1988-05-26 | 1991-03-28 | Bernardini Attilio | |
IT1240799B (it) * | 1990-03-15 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare. |
IT1245869B (it) * | 1991-06-05 | 1994-10-25 | Sigma Tau Ind Farmaceuti | Impiego di propionil l-carnitina per il recupero del tono muscolare in soggetti immobilizzati |
IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
US5707971A (en) * | 1995-06-07 | 1998-01-13 | Life Resuscitation Technologies, Inc. | Modulation of glycolytic ATP production |
IT1277897B1 (it) * | 1995-08-03 | 1997-11-12 | Mendes Srl | Uso della l-carnitina,di suoi derivati e di loro sali farmaceuticamen- te accettabili in combinazione con farmaci antiretrovirali per ridurre |
IT1277898B1 (it) * | 1995-08-03 | 1997-11-12 | Mendes Srl | Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie |
IT1283951B1 (it) * | 1996-03-15 | 1998-05-07 | Mendes Srl | Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di |
IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
IT1291127B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
IT1302125B1 (it) * | 1998-08-03 | 2000-07-31 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed antiproliferativacomprendente una carnitina ed un carotenoide |
IT1306173B1 (it) * | 1999-07-23 | 2001-05-30 | Sigma Tau Healthscience Spa | Composizione per la prevenzione degli affaticamenti muscolari e permigliorare il rendimento energetico muscolare. |
US20040229951A1 (en) * | 2003-05-15 | 2004-11-18 | Arthur Vanmoor | Method of treating fatigue by enhancing the effectiveness of the human immune system |
ES2670836T3 (es) * | 2010-06-16 | 2018-06-01 | Alfasigma S.P.A. | Acetil-carnitina para uso en un método para incrementar la neurogénesis en el tejido neuronal |
IT202100020729A1 (it) | 2021-08-02 | 2023-02-02 | Univ Degli Studi Di Napoli Federico Ii | Preparazione combinata per il trattamento della malattia di Pompe |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1573430A (fr) * | 1967-07-03 | 1969-07-04 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE719891C (de) * | 1938-12-08 | 1942-04-21 | Dr Erich Strack | Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins |
US3624887A (en) * | 1970-03-02 | 1971-12-07 | Bunker Ramo | Pin and socket removal tool |
US3968241A (en) * | 1972-11-06 | 1976-07-06 | Defelice Stephen L | Method of treating cardiac arrhythmias and of improving myocardial contractility and systolic rhythm with carnitive or a pharmaceutically acceptable salt thereof |
JPS531812B2 (fr) * | 1972-12-07 | 1978-01-23 |
-
1978
- 1978-03-30 AU AU34598/78A patent/AU518617B2/en not_active Expired
- 1978-03-31 IE IE643/78A patent/IE46703B1/en not_active IP Right Cessation
- 1978-04-07 GB GB13769/78A patent/GB1596491A/en not_active Expired
- 1978-04-10 US US05/895,044 patent/US4194006A/en not_active Expired - Lifetime
- 1978-04-20 DE DE19782817358 patent/DE2817358A1/de active Granted
- 1978-04-21 FR FR7811863A patent/FR2388556A1/fr active Granted
- 1978-04-27 CH CH460478A patent/CH636268A5/it not_active IP Right Cessation
- 1978-04-27 NL NLAANVRAGE7804567,A patent/NL188078C/xx not_active IP Right Cessation
- 1978-04-28 BE BE187276A patent/BE866568A/fr not_active IP Right Cessation
- 1978-04-28 JP JP5325878A patent/JPS53136523A/ja active Granted
-
1982
- 1982-07-15 KE KE3223A patent/KE3223A/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1573430A (fr) * | 1967-07-03 | 1969-07-04 |
Non-Patent Citations (1)
Title |
---|
CA1975 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2414914A1 (fr) * | 1978-01-18 | 1979-08-17 | Sigma Tau Ind Farmaceuti | Utilisations therapeutiques nouvelles de l'acetyl-1-carnitine et d'autres derives acyles de la 1-carnitine |
FR2425855A1 (fr) * | 1978-05-15 | 1979-12-14 | Cavazza Claudio | Application des acyl-carnitines a un procede therapeutique de traitement de patients uremiques chroniques en traitement hemodialytique periodique et composition liquide de dialyse pour la mise en oeuvre d'un tel procede |
FR2448348A1 (fr) * | 1979-02-12 | 1980-09-05 | Cavazza Claudio | Composition pharmaceutique comprenant une acyl-carnitine pour le traitement du metabolisme cerebral perturbe |
FR2448347A1 (fr) * | 1979-02-12 | 1980-09-05 | Cavazza Claudio | Composition pharmaceutique comprenant une acyl-carnitine pour le traitement des maladies vasculaires peripheriques |
US4439438A (en) * | 1979-04-23 | 1984-03-27 | Claudio Cavazza | Esters of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such esters |
US4443475A (en) * | 1979-04-23 | 1984-04-17 | Claudio Cavazza | Amides of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such amides |
EP0162764A1 (fr) * | 1984-05-02 | 1985-11-27 | Merck & Co. Inc. | Composition et méthode pour améliorer la résorption d'un médicament dans le faisceau gastro-intestinal employant des acylcarnitines |
EP0442850A1 (fr) * | 1990-02-12 | 1991-08-21 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Esters d'acyl L-carnitines avec l'acide gamma-hydroxybutyrique et compositions pharmaceutiques les contenant pour inhiber la dégénération neuronale et pour le traitement du coma |
WO2000000183A2 (fr) * | 1998-06-30 | 2000-01-06 | Sigma-Tau Healthscience S.P.A. | Composition antioxydante, cytostatique et a energie durable, ameliorant l'utilisation metabolique du glucose |
WO2000000183A3 (fr) * | 1998-06-30 | 2000-06-29 | Sigma Tau Healthscience Spa | Composition antioxydante, cytostatique et a energie durable, ameliorant l'utilisation metabolique du glucose |
Also Published As
Publication number | Publication date |
---|---|
IE780643L (en) | 1978-10-29 |
KE3223A (en) | 1982-09-03 |
AU3459878A (en) | 1979-10-04 |
NL188078B (nl) | 1991-11-01 |
DE2817358C2 (fr) | 1989-04-27 |
BE866568A (fr) | 1978-08-14 |
JPS53136523A (en) | 1978-11-29 |
GB1596491A (en) | 1981-08-26 |
NL188078C (nl) | 1992-04-01 |
JPH0115483B2 (fr) | 1989-03-17 |
AU518617B2 (en) | 1981-10-08 |
CH636268A5 (it) | 1983-05-31 |
NL7804567A (nl) | 1978-10-31 |
IE46703B1 (en) | 1983-08-24 |
DE2817358A1 (de) | 1978-11-02 |
US4194006A (en) | 1980-03-18 |
FR2388556B1 (fr) | 1981-05-29 |
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