ES2078019T3 - Amidas de alcanoil l-carnitina con aminoacidos y composiciones farmaceuticas que las contienen para promover regeneracion del tejido nervioso, inhibir degeneracion neuronal, mejorar el proceso de aprendimiento y memoria y para el tratamiento de coma. - Google Patents

Amidas de alcanoil l-carnitina con aminoacidos y composiciones farmaceuticas que las contienen para promover regeneracion del tejido nervioso, inhibir degeneracion neuronal, mejorar el proceso de aprendimiento y memoria y para el tratamiento de coma.

Info

Publication number
ES2078019T3
ES2078019T3 ES92830224T ES92830224T ES2078019T3 ES 2078019 T3 ES2078019 T3 ES 2078019T3 ES 92830224 T ES92830224 T ES 92830224T ES 92830224 T ES92830224 T ES 92830224T ES 2078019 T3 ES2078019 T3 ES 2078019T3
Authority
ES
Spain
Prior art keywords
treatment
learning
carnitine
amides
nervous tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92830224T
Other languages
English (en)
Inventor
Giulio Taglialatela
Nicola Fanto'
Mose Santaniello
Claudio Cavazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2078019T3 publication Critical patent/ES2078019T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

AMIDAS DE L-CARNITINAS DE ALKANOIL DE LA FORMULA GENERAL (1). EN DONDE R ES UN GRUPO ALKANOIL PURO O RAMIFICADO QUE TIENE DE 2 A 8 ATOMOS DE CARBONO SELECCIONADOS DE ACETIL, PROPIONIL, BUTIRIL, ISOBUTIRIL, VALERIL, ISOVALERIL, HEXANOIL, 1METILBUTIRIL, T-BUTILACETIL, 2-ETILBUTIRIL, 3-METILVALERIL, 4METILVALERIL, 2-ETILHEXANOIL Y 2-PROPILPENTANOIL; R'' ES EL RESIDUO MONOVALENTE DE UN AMINOACIDO PRODUCIDO DE FORMA NATURAL SELECCIONADO DE: Y X TABLE ACTIVO EN LA REGENERACION DEL TEJIDO NERVIOSO, INHIBICION DE LA DEGENERACION NEURONAL, MEJORIA DE LOS PROCESOS DE APRENDIZAJE Y MEMORIA Y PARA EL TRATAMIENTO DEL COMA. COMPOSICIONES DE ADMINISTRACION ORAL O PARENTERAL EN FORMA DE DOSIS UNITARIA COMPRENDEN ENTRE 50 Y 500 MG DE UNA AMIDA DE LA FORMULA (1).
ES92830224T 1991-05-16 1992-05-14 Amidas de alcanoil l-carnitina con aminoacidos y composiciones farmaceuticas que las contienen para promover regeneracion del tejido nervioso, inhibir degeneracion neuronal, mejorar el proceso de aprendimiento y memoria y para el tratamiento de coma. Expired - Lifetime ES2078019T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910333A IT1248323B (it) 1991-05-16 1991-05-16 Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti

Publications (1)

Publication Number Publication Date
ES2078019T3 true ES2078019T3 (es) 1995-12-01

Family

ID=11400146

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92830224T Expired - Lifetime ES2078019T3 (es) 1991-05-16 1992-05-14 Amidas de alcanoil l-carnitina con aminoacidos y composiciones farmaceuticas que las contienen para promover regeneracion del tejido nervioso, inhibir degeneracion neuronal, mejorar el proceso de aprendimiento y memoria y para el tratamiento de coma.

Country Status (12)

Country Link
US (1) US5270472A (es)
EP (1) EP0514359B1 (es)
JP (1) JP3222195B2 (es)
AT (1) ATE127780T1 (es)
CA (1) CA2068752C (es)
DE (1) DE69204737T2 (es)
DK (1) DK0514359T3 (es)
ES (1) ES2078019T3 (es)
GR (1) GR3017456T3 (es)
HK (1) HK1005863A1 (es)
IE (1) IE921575A1 (es)
IT (1) IT1248323B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254314B (it) * 1992-03-27 1995-09-14 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it) 1995-12-15 1997-10-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1291113B1 (it) * 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US5863940A (en) 1997-12-01 1999-01-26 Sigma-Tau Healthscience S.P.A. Medicament and therapeutical method for treating idiopathic asthenozoospermia
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US5958886A (en) * 1998-01-13 1999-09-28 Sigma-Tau Pharmaceuticals, Inc. Carnitine-containing peptides and a method for using the same
PT951909E (pt) 1998-03-19 2004-04-30 Sigma Tau Ind Farmaceuti Composicao combinada que contem uma l-carnitina ou uma alcanoil-l-carnitina um glicosaminoglicano e/ou um seu constituinte
IT1306186B1 (it) * 1999-09-03 2001-05-30 Biosalts Srl Sali non igroscopici di principi attivi ad attivita' terapeutica e/onutrizionale e composizioni atte alla somministrazione orale
IT1316998B1 (it) * 2000-03-02 2003-05-26 Sigma Tau Healthscience Spa Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori.
CN1995010B (zh) * 2006-12-29 2012-12-12 辽宁科硕营养科技有限公司 一种合成丙酰左旋肉碱盐酸盐的方法
PL2582368T3 (pl) 2010-06-16 2018-08-31 Alfasigma S.P.A. Acetylo-karnityna do zastosowania w sposobie zwiększania neurogenezy w tkance nerwowej
US9572848B1 (en) 2014-03-26 2017-02-21 Aemes Research L.L.L.P. Composition of matter for sexual dysfunction
CN112851747B (zh) * 2019-11-12 2024-03-05 深圳翰宇药业股份有限公司 一种含季铵碱衍生物修饰的多肽合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione

Also Published As

Publication number Publication date
HK1005863A1 (en) 1999-01-29
US5270472A (en) 1993-12-14
EP0514359A3 (en) 1993-03-10
IT1248323B (it) 1995-01-05
CA2068752C (en) 2003-01-14
DE69204737T2 (de) 1996-02-29
ITRM910333A0 (it) 1991-05-16
ATE127780T1 (de) 1995-09-15
EP0514359A2 (en) 1992-11-19
DK0514359T3 (da) 1995-11-13
ITRM910333A1 (it) 1992-11-16
GR3017456T3 (en) 1995-12-31
JP3222195B2 (ja) 2001-10-22
IE921575A1 (en) 1992-11-18
JPH0649004A (ja) 1994-02-22
CA2068752A1 (en) 1992-11-17
EP0514359B1 (en) 1995-09-13
DE69204737D1 (de) 1995-10-19

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