KR940008681A - 디클로페낙 염용 비경구 용액 - Google Patents

디클로페낙 염용 비경구 용액 Download PDF

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Publication number
KR940008681A
KR940008681A KR1019930021919A KR930021919A KR940008681A KR 940008681 A KR940008681 A KR 940008681A KR 1019930021919 A KR1019930021919 A KR 1019930021919A KR 930021919 A KR930021919 A KR 930021919A KR 940008681 A KR940008681 A KR 940008681A
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South Korea
Prior art keywords
glutathione
acetylcysteine
acid
acceptable
hydroxy
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KR1019930021919A
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English (en)
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갈리 브루노
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베르너 발데크
시바-가이기 에이지
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Publication of KR940008681A publication Critical patent/KR940008681A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 디클로페낙 및 글루타치온 또는 N-아세틸 시스테인과 결합한 에틸 아세테이트와 같은 안정화제를 포함한 멸균가능한 비경구 용액의 형태로 존재하는 약제학적 조성물에 관한 것이다.

Description

디클로페낙 염용 비경구 용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. a)디클로페낙의 약제학적으로 허용되는 염; b)가용화제로서 1,2-프로필렌 글리콜 또는 폴리에틸렌 글리콜300내지 400; c)글루타치온, C2-3알칸카복실산C2-4알킬 에스테르, 또는 하이드록시 -C2-4알칸카복실산 C2-4알킬 에스테르 또는 N-아세틸시스테인과 결합된 글루타치온 및 C2-3알칸카복실산 C2-4알킬 에스테르, 또는 하이드록시-C2-4알칸카복실산 C2-4알칸카복실산 C2-4알킬 에스테르와 결합한 N-아세틸시스테인 및 d)주사용 제형에 대해 허용되는 담체액체, 경우에 따라, 이에 대해 허용되는 추가 부형제를 포함하는 비경구적으로 투여가능한 주사액의 형태로 존재하는 약제학적 조성물.
  2. 제1항에 있어서, a)디클로로페낙의 나트륨 염; b)가용화제로서 1,2-프로필렌 글리콜 도는 폴리에틸렌 글리콜300; c)안정화제로서 글루타치온 또는 N-아세틸시스테인과 결합된 에틸 락테이트 및 d)주사용 제형에 대해 허용되는 담체 액체, 경우에 따라, 이에 대해 허용되는 추가 부형제를 포함하는 약제학적 조성물의 제조방법.
  3. 담체 액제 d)중 성분 a), b)및 c)를 어더한 목적하는 순서대로 용해시키고,경우에 따라, 주사제형에 허용되는 추가 부형제를 가함을 특징으로 하는, 제1항에 따른 약제학적 조성물의 제조방법.
  4. 디클로페낙의 약제학적으로 허용되는 염의 비경구적 투여용 약제학적 조성물을 제조하는데 있어서, 글루타치온, C2-3알칸카복실산C2-4알킬 에스테르, 또는 하이드록시 -C2-4알칸카복실산 C2-4알킬 에스테르 또는 N-아세틸시스테인과 결합된 글루타치온 및 C2-3알칸카복실산 C2-4알킬 에스테르, 또는 하이드록시-C2-4알칸카복실산 C2-4알칸카복실산 C2-4알킬 에스테르와 결합한 N-아세틸시스테인으로 이루어진 그룹에서 선택한 약제학적으로 허용되는 안정화제의 용도
  5. 사람 또는 동물 신체의 치료적 처리를 위한 방법에서 사용하기 위한 제1항에 따른 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930021919A 1992-10-22 1993-10-21 디클로페낙 염용 비경구 용액 KR940008681A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH03275/92-9 1992-10-22
CH327592 1992-10-22

Publications (1)

Publication Number Publication Date
KR940008681A true KR940008681A (ko) 1994-05-16

Family

ID=4252473

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930021919A KR940008681A (ko) 1992-10-22 1993-10-21 디클로페낙 염용 비경구 용액

Country Status (11)

Country Link
US (1) US5389681A (ko)
EP (1) EP0595766A1 (ko)
JP (1) JPH06199662A (ko)
KR (1) KR940008681A (ko)
AU (1) AU4905293A (ko)
CA (1) CA2108820A1 (ko)
FI (1) FI934593A (ko)
HU (1) HUT75684A (ko)
IL (1) IL107353A0 (ko)
NO (1) NO933782L (ko)
ZA (1) ZA937822B (ko)

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US5554650A (en) * 1994-07-28 1996-09-10 Southern Research Institute Antiphlogistic, analgesic, antipyretic injection preparation
IT1286778B1 (it) * 1996-11-20 1998-07-17 Alfa Wassermann Spa Capsule contenenti diclofenac o suoi sali in soluzione
JP2001524087A (ja) * 1997-04-18 2001-11-27 クリンゲ ファーマ ジーエムビーエイチ システイニル誘導体を含有する安定化された薬剤
DE50104197D1 (de) * 2000-12-28 2004-11-25 Fresenius Kabi Austria Gmbh Gr Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung
AT413794B (de) * 2002-09-19 2006-06-15 Mayrhofer Pharmazeutika Ges M Pharmazeutische zubereitung von diclofenac-natrium
CA2521603A1 (en) * 2003-04-07 2004-10-21 Jurox Pty Ltd Stable carprofen composition
FR2862872A1 (fr) * 2003-12-02 2005-06-03 Palbian Snc Composition a l'etat aqueux pour l'application perfusable d'un principe actif, notamment pharmacologique tel que le paracetamol.
DK1767219T3 (da) * 2004-03-10 2010-05-10 Shimoda Biotech Pty Ltd Stabile injicerbare diclofenac-sammensætninger
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JP4866546B2 (ja) * 2004-12-10 2012-02-01 久光製薬株式会社 ジクロフェナク含有乳剤性軟膏剤
AP2888A (en) * 2005-02-01 2014-05-31 Troikaa Pharmaceuticals Ltd Injectable preparations of diclofenic and its pharmaceutically acceptable salts
MX2007014862A (es) * 2005-05-27 2008-02-21 Panacea Biotec Ltd Composiciones inyectables y procedimiento para la preparacion de dichas composiciones.
MX2008012496A (es) 2006-03-28 2009-01-07 Javelin Pharmaceuticals Inc Formulaciones de farmacos anti-inflamatorios no esteroidales de baja dosis y beta-ciclodextrina.
AU2007230716B2 (en) 2006-03-28 2012-05-03 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US9211251B2 (en) * 2007-07-30 2015-12-15 Troikaa Pharmaceuticals Limited Injectable preparations of diclofenac and its pharmaceutically acceptable salts
EP2398459B1 (en) * 2009-01-30 2018-10-17 Kydes Pharmaceuticals, Llc Transdermal delivery of diclofenac, carbamazepine and benzydamine
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
GB0914286D0 (en) * 2009-08-14 2009-09-30 Pci Biotech As Method
WO2012068105A2 (en) 2010-11-15 2012-05-24 Archer Daniels Midland Company Compositions and uses thereof in converting contaminants
US20140221490A1 (en) 2011-07-20 2014-08-07 Hospira, Inc. Methods of treating pain
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US20140275261A1 (en) 2013-03-15 2014-09-18 Dr. Reddy's Laboratories, Inc. Diclofenac parenteral compositions
CN103432132B (zh) * 2013-08-31 2015-01-21 西南大学 甲磺酸普立地诺双氯芬酸钠注射液及其制备方法
CN104288096A (zh) * 2014-06-24 2015-01-21 郑州百瑞动物药业有限公司 一种用于治疗奶牛发热及蹄病的注射液及其制备方法
WO2016170401A1 (en) * 2015-04-20 2016-10-27 Umedica Laboratories Pvt. Ltd Novel injectable composition of diclofenac sodium
US11110073B2 (en) 2017-03-24 2021-09-07 Cadila Healthcare Limited Storage stable aqueous injectable solution comprising diclofenac
GR1009729B (el) * 2018-08-02 2020-05-15 Win Medica Φαρμακευτικη Ανωνυμη Εταιρεια Σταθερος ενεσιμος συνδυασμος
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US5079001A (en) * 1989-11-03 1992-01-07 Ciba-Geigy Corporation Liquid oral formulation of diclofenac

Also Published As

Publication number Publication date
NO933782D0 (no) 1993-10-21
HU9302985D0 (en) 1994-01-28
FI934593A (fi) 1994-04-23
NO933782L (no) 1994-04-25
FI934593A0 (fi) 1993-10-18
IL107353A0 (en) 1994-01-25
US5389681A (en) 1995-02-14
JPH06199662A (ja) 1994-07-19
CA2108820A1 (en) 1994-04-23
ZA937822B (en) 1994-04-22
HUT75684A (en) 1997-05-28
AU4905293A (en) 1994-05-05
EP0595766A1 (de) 1994-05-04

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