ES2056620T3 - Esteres de (r) (-)-carnitina y acil (r) (-)-carnitinas con acido beta hidroxibutirico y composiciones farmaceuticas que las contienen para inhibir la degeneracion neuronal, proteolisis de higado y para el tratamiento de coma. - Google Patents

Esteres de (r) (-)-carnitina y acil (r) (-)-carnitinas con acido beta hidroxibutirico y composiciones farmaceuticas que las contienen para inhibir la degeneracion neuronal, proteolisis de higado y para el tratamiento de coma.

Info

Publication number
ES2056620T3
ES2056620T3 ES91830062T ES91830062T ES2056620T3 ES 2056620 T3 ES2056620 T3 ES 2056620T3 ES 91830062 T ES91830062 T ES 91830062T ES 91830062 T ES91830062 T ES 91830062T ES 2056620 T3 ES2056620 T3 ES 2056620T3
Authority
ES
Spain
Prior art keywords
acid
acil
carnitines
carnitine
proteolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91830062T
Other languages
English (en)
Inventor
Maria Ornella Tinti
Nazareno Scafetta
Domenico Misiti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2056620T3 publication Critical patent/ES2056620T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

LOS ESTERES DE CARNITINA-(R) (-) Y ACIL CARNITINAS-(R) (-) CON ACIDO BETA-HIDROXIBUTIRICO EN LA FORMA DE SALES ACEPTADAS FARMACEUTICAMENTE DE LA FORMULA (1) DONDE X ELEVADO ION DE UNA SAL ACEPTADA FARMACEUTICAMENTE, POR EJ. CLORURO, BROMURO, OROTATO, ASPARTATO ACIDO, CITRATO ACIDO, FOSFATO ACIDO, FUMARATO ACIDO, LACTATO, MALEATO ACIDO, OXALATATO ACIDO, SULFATO ACIDO Y GLUCOSOFOSFATO O EN LA FORMA DE SALES INTERNAS DE LA FORMULA (I'') DONDE R ES HIDROGENO O UN GRUPO ACILO RECTO O RAMIFICADO TENIENDO DE 2 A 5 ATOMOS DE CARBONO, COMO POR EJEMPLO ACETILO, PROPINOILO, BUTIRILO-N, ISOBUTIRILO Y ISOVALERILO, SON ACTIVOS EN LA INHIBICION DE DEGENERACION NEURONAS (COMO OCURRE EN LA DEMENCIA SENIL DE ALZHEIMER Y ENFERMEDAD DE PARKINSON), PROTEOLISIS DEL HIGADO Y EN EL TRATAMIENTO DEL COMA.
ES91830062T 1990-02-23 1991-02-21 Esteres de (r) (-)-carnitina y acil (r) (-)-carnitinas con acido beta hidroxibutirico y composiciones farmaceuticas que las contienen para inhibir la degeneracion neuronal, proteolisis de higado y para el tratamiento de coma. Expired - Lifetime ES2056620T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47669A IT1240775B (it) 1990-02-23 1990-02-23 Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Publications (1)

Publication Number Publication Date
ES2056620T3 true ES2056620T3 (es) 1994-10-01

Family

ID=11261785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91830062T Expired - Lifetime ES2056620T3 (es) 1990-02-23 1991-02-21 Esteres de (r) (-)-carnitina y acil (r) (-)-carnitinas con acido beta hidroxibutirico y composiciones farmaceuticas que las contienen para inhibir la degeneracion neuronal, proteolisis de higado y para el tratamiento de coma.

Country Status (8)

Country Link
EP (1) EP0443996B1 (es)
JP (1) JP2930755B2 (es)
AT (1) ATE107624T1 (es)
DE (1) DE69102560T2 (es)
DK (1) DK0443996T3 (es)
ES (1) ES2056620T3 (es)
HK (1) HK1005868A1 (es)
IT (1) IT1240775B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
RU2224510C2 (ru) * 1997-03-17 2004-02-27 Би Ти Джи Интернэшнл Лимитед Терапевтические композиции
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
US20020006959A1 (en) * 2000-05-01 2002-01-17 Henderson Samuel T. Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism
KR101634083B1 (ko) 2006-04-03 2016-06-28 액세라인크 나이와 관련된 기억 손상의 치료를 위한 케톤 생성 조성물의 용도
CN1995010B (zh) * 2006-12-29 2012-12-12 辽宁科硕营养科技有限公司 一种合成丙酰左旋肉碱盐酸盐的方法
KR101335021B1 (ko) 2007-07-31 2013-12-12 액세라인크 게놈 테스트의 용도 및 인지 기능 저하 치료용 케톤성 화합물
US9125881B2 (en) 2008-07-03 2015-09-08 Accera, Inc. Monoglyceride of acetoacetate and derivatives for the treatment of neurological disorders
CN112341331B (zh) * 2019-08-07 2023-04-07 辽宁科硕营养科技股份有限公司 一种3-羟基丁酸盐及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) * 1980-03-06 1986-11-05 Sigma Tau Ind Farmaceuti Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.

Also Published As

Publication number Publication date
DK0443996T3 (da) 1994-07-25
DE69102560T2 (de) 1994-10-13
JP2930755B2 (ja) 1999-08-03
ATE107624T1 (de) 1994-07-15
HK1005868A1 (en) 1999-01-29
IT9047669A1 (it) 1991-08-24
JPH0597785A (ja) 1993-04-20
IT9047669A0 (it) 1990-02-23
EP0443996B1 (en) 1994-06-22
DE69102560D1 (de) 1994-07-28
EP0443996A1 (en) 1991-08-28
IT1240775B (it) 1993-12-17

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