HK1005868A1 - Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutryric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration liver proteolysis and for the treatment of coma - Google Patents

Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutryric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration liver proteolysis and for the treatment of coma

Info

Publication number
HK1005868A1
HK1005868A1 HK98104950A HK98104950A HK1005868A1 HK 1005868 A1 HK1005868 A1 HK 1005868A1 HK 98104950 A HK98104950 A HK 98104950A HK 98104950 A HK98104950 A HK 98104950A HK 1005868 A1 HK1005868 A1 HK 1005868A1
Authority
HK
Hong Kong
Prior art keywords
acid
carnitines
carnitine
coma
beta
Prior art date
Application number
HK98104950A
Other languages
English (en)
Inventor
Maria Ornella Tinti
Nazareno Scafetta
Domenico Misiti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of HK1005868A1 publication Critical patent/HK1005868A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK98104950A 1990-02-23 1998-06-05 Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutryric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration liver proteolysis and for the treatment of coma HK1005868A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47669A IT1240775B (it) 1990-02-23 1990-02-23 Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Publications (1)

Publication Number Publication Date
HK1005868A1 true HK1005868A1 (en) 1999-01-29

Family

ID=11261785

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104950A HK1005868A1 (en) 1990-02-23 1998-06-05 Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutryric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration liver proteolysis and for the treatment of coma

Country Status (8)

Country Link
EP (1) EP0443996B1 (es)
JP (1) JP2930755B2 (es)
AT (1) ATE107624T1 (es)
DE (1) DE69102560T2 (es)
DK (1) DK0443996T3 (es)
ES (1) ES2056620T3 (es)
HK (1) HK1005868A1 (es)
IT (1) IT1240775B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
KR100839689B1 (ko) * 1997-03-17 2008-06-18 비티지 인터내셔널 리미티드 치료용 조성물
US20020006959A1 (en) * 2000-05-01 2002-01-17 Henderson Samuel T. Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
KR101634083B1 (ko) 2006-04-03 2016-06-28 액세라인크 나이와 관련된 기억 손상의 치료를 위한 케톤 생성 조성물의 용도
CN1995010B (zh) * 2006-12-29 2012-12-12 辽宁科硕营养科技有限公司 一种合成丙酰左旋肉碱盐酸盐的方法
PT2650381T (pt) 2007-07-31 2016-12-29 Accera Inc Utilização de testagem genómica e compostos cetogénicos para o tratamento de função cognitiva reduzida
JP5674652B2 (ja) 2008-07-03 2015-02-25 アクセラ・インコーポレーテッド 神経障害の処置のためのアセトアセテートのモノグリセリドおよび誘導体
CN112341331B (zh) * 2019-08-07 2023-04-07 辽宁科硕营养科技股份有限公司 一种3-羟基丁酸盐及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) * 1980-03-06 1986-11-05 Sigma Tau Ind Farmaceuti Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.

Also Published As

Publication number Publication date
DK0443996T3 (da) 1994-07-25
DE69102560D1 (de) 1994-07-28
EP0443996A1 (en) 1991-08-28
JP2930755B2 (ja) 1999-08-03
ES2056620T3 (es) 1994-10-01
IT9047669A1 (it) 1991-08-24
IT9047669A0 (it) 1990-02-23
EP0443996B1 (en) 1994-06-22
DE69102560T2 (de) 1994-10-13
ATE107624T1 (de) 1994-07-15
IT1240775B (it) 1993-12-17
JPH0597785A (ja) 1993-04-20

Similar Documents

Publication Publication Date Title
HK1005859A1 (en) Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
HK1005868A1 (en) Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutryric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration liver proteolysis and for the treatment of coma
CA1252098A (en) Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
EP0429403A3 (en) Ester of l-carnitine with gamma-hydroxybutyric acid and pharmaceutical compositions containing it for inhibiting neuronal degeneration and for the treatment of coma
ITRM910333A1 (it) Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
HK1005724A1 (en) Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antibacterial activity
EP0514357B1 (en) Use of esters of acyl L-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
DE69410866T2 (de) Verwendung von Ester von Acyl-L-Carnitin mit Gammahydroxybuttersäure zur Behandlung von Alkoholismus

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090221