DE69102560T2 - Ester von (R)(-)-Carnitin und Acyl (R)(-)-Carnitin mit Beta-Hydroxybuttersäure und diese enthaltende pharmazeutische Zusammensetzungen zur Inhibierung von neuronaler Degeneration, Leberproteolyse und zur Behandlung von Koma. - Google Patents
Ester von (R)(-)-Carnitin und Acyl (R)(-)-Carnitin mit Beta-Hydroxybuttersäure und diese enthaltende pharmazeutische Zusammensetzungen zur Inhibierung von neuronaler Degeneration, Leberproteolyse und zur Behandlung von Koma.Info
- Publication number
- DE69102560T2 DE69102560T2 DE69102560T DE69102560T DE69102560T2 DE 69102560 T2 DE69102560 T2 DE 69102560T2 DE 69102560 T DE69102560 T DE 69102560T DE 69102560 T DE69102560 T DE 69102560T DE 69102560 T2 DE69102560 T2 DE 69102560T2
- Authority
- DE
- Germany
- Prior art keywords
- acid
- carnitine
- coma
- beta
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT47669A IT1240775B (it) | 1990-02-23 | 1990-02-23 | Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69102560D1 DE69102560D1 (de) | 1994-07-28 |
DE69102560T2 true DE69102560T2 (de) | 1994-10-13 |
Family
ID=11261785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69102560T Expired - Fee Related DE69102560T2 (de) | 1990-02-23 | 1991-02-21 | Ester von (R)(-)-Carnitin und Acyl (R)(-)-Carnitin mit Beta-Hydroxybuttersäure und diese enthaltende pharmazeutische Zusammensetzungen zur Inhibierung von neuronaler Degeneration, Leberproteolyse und zur Behandlung von Koma. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0443996B1 (de) |
JP (1) | JP2930755B2 (de) |
AT (1) | ATE107624T1 (de) |
DE (1) | DE69102560T2 (de) |
DK (1) | DK0443996T3 (de) |
ES (1) | ES2056620T3 (de) |
HK (1) | HK1005868A1 (de) |
IT (1) | IT1240775B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
IT1254135B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
IT1254136B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica. |
IT1263013B (it) * | 1992-10-20 | 1996-07-23 | Avantgarde Spa | Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee. |
IT1261984B (it) * | 1993-06-22 | 1996-06-11 | Avantgarde Spa | Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
ES2530753T3 (es) * | 1997-03-17 | 2015-03-05 | Btg Int Ltd | Composiciones terapéuticas que comprenden cuerpos cetónicos y precursores de los mismos |
US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
ES2323940T3 (es) | 2000-05-01 | 2009-07-28 | Accera, Inc. | Uso de trigliceridos de cadena media para el tratamiento y prevencion de la enfermedad de alzheimer. |
EP2001293B9 (de) | 2006-04-03 | 2019-04-17 | Accera, Inc. | Verwendung ketogener verbindungen zur behandlung altersbedingter gedächtnisschwächen |
CN1995010B (zh) * | 2006-12-29 | 2012-12-12 | 辽宁科硕营养科技有限公司 | 一种合成丙酰左旋肉碱盐酸盐的方法 |
PT2650378E (pt) | 2007-07-31 | 2016-01-14 | Accera Inc | Utilização de testagem genómica e compostos cetogénicos para o tratamento de função cognitiva reduzida |
CN105640931A (zh) | 2008-07-03 | 2016-06-08 | 艾克塞拉公司 | 用于治疗神经性障碍的乙酰乙酸的单甘油酯及其衍生物 |
CN112341331B (zh) * | 2019-08-07 | 2023-04-07 | 辽宁科硕营养科技股份有限公司 | 一种3-羟基丁酸盐及其制备方法与应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
IT1145362B (it) * | 1980-03-06 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
IT1209564B (it) * | 1984-06-29 | 1989-08-30 | Magis Farmaceutici | Derivati della l-carnitina o di l-acil carnitina. |
-
1990
- 1990-02-23 IT IT47669A patent/IT1240775B/it active IP Right Grant
-
1991
- 1991-02-21 EP EP91830062A patent/EP0443996B1/de not_active Expired - Lifetime
- 1991-02-21 DK DK91830062.5T patent/DK0443996T3/da active
- 1991-02-21 ES ES91830062T patent/ES2056620T3/es not_active Expired - Lifetime
- 1991-02-21 AT AT91830062T patent/ATE107624T1/de not_active IP Right Cessation
- 1991-02-21 DE DE69102560T patent/DE69102560T2/de not_active Expired - Fee Related
- 1991-02-22 JP JP3050644A patent/JP2930755B2/ja not_active Expired - Fee Related
-
1998
- 1998-06-05 HK HK98104950A patent/HK1005868A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1005868A1 (en) | 1999-01-29 |
IT9047669A0 (it) | 1990-02-23 |
EP0443996B1 (de) | 1994-06-22 |
DK0443996T3 (da) | 1994-07-25 |
IT9047669A1 (it) | 1991-08-24 |
ES2056620T3 (es) | 1994-10-01 |
JP2930755B2 (ja) | 1999-08-03 |
ATE107624T1 (de) | 1994-07-15 |
DE69102560D1 (de) | 1994-07-28 |
EP0443996A1 (de) | 1991-08-28 |
JPH0597785A (ja) | 1993-04-20 |
IT1240775B (it) | 1993-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |