ES2056432T3 - Ester de l-carnitina con acido gamma-hidroxibutirico y composiciones farmaceuticas que lo contienen para inhibir degeneracion neuronal y para el tratamiento de coma. - Google Patents

Ester de l-carnitina con acido gamma-hidroxibutirico y composiciones farmaceuticas que lo contienen para inhibir degeneracion neuronal y para el tratamiento de coma.

Info

Publication number
ES2056432T3
ES2056432T3 ES90830465T ES90830465T ES2056432T3 ES 2056432 T3 ES2056432 T3 ES 2056432T3 ES 90830465 T ES90830465 T ES 90830465T ES 90830465 T ES90830465 T ES 90830465T ES 2056432 T3 ES2056432 T3 ES 2056432T3
Authority
ES
Spain
Prior art keywords
acid
coma
treatment
carnitine
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90830465T
Other languages
English (en)
Inventor
Maria Ornella Tinti
Domenico Misiti
Claudio Cavazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2056432T3 publication Critical patent/ES2056432T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

ESTER DE L-CARNITINA CON ACIDO HIDROXIBUTIRICO Y SALES FARMACOLOGICAMENTE ACEPTABLES DE LA FORMULA EN LA CUAL X-ES EL ANION DE UNA SAL FARMACOLOGICAMENTE ACEPTABLE, POR EJEMPLO, CLORO, BROMURO, OROTATO, ASPARTATO DE ACIDO, CITRATO DE ACIDO, FOSFATOD E ACIDO, FUMARATO DE ACIDO, LACTATO, MALEATO DE ACIDO, OXALATO DE ACIDO, SULFATO DE ACIDO Y GLUCOFOSFATO; TODOS ELLOS SON ACTIVOS EN LA INHIBICION DE LA DEGENERACION NEURONAL (COMO OCURRE EN LA DEMENCIA SENIL DE ALZHEIMER Y EN LA ENFERMEDAD DE PARKINSON) Y EN EL TRATAMIENTO DEL COMA.
ES90830465T 1989-10-20 1990-10-18 Ester de l-carnitina con acido gamma-hidroxibutirico y composiciones farmaceuticas que lo contienen para inhibir degeneracion neuronal y para el tratamiento de coma. Expired - Lifetime ES2056432T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04847589A IT1238344B (it) 1989-10-20 1989-10-20 Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma

Publications (1)

Publication Number Publication Date
ES2056432T3 true ES2056432T3 (es) 1994-10-01

Family

ID=11266785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90830465T Expired - Lifetime ES2056432T3 (es) 1989-10-20 1990-10-18 Ester de l-carnitina con acido gamma-hidroxibutirico y composiciones farmaceuticas que lo contienen para inhibir degeneracion neuronal y para el tratamiento de coma.

Country Status (9)

Country Link
US (1) US5547986A (es)
EP (1) EP0429403B1 (es)
JP (1) JP2883187B2 (es)
AT (1) ATE108175T1 (es)
DE (1) DE69010459T2 (es)
DK (1) DK0429403T3 (es)
ES (1) ES2056432T3 (es)
HK (1) HK1005858A1 (es)
IT (1) IT1238344B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it) 1995-12-15 1997-10-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
EP0951909B2 (en) 1998-03-19 2010-10-20 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Combination composition comprising a L-carnitine or an alkanoyl-L-carnitine, a glycosaminoglycan and/or constituent thereof
ES2240163T3 (es) 1999-09-14 2005-10-16 Tepha, Inc. Utilizaciones terapeuticas de polimeros y de oligomeros a base de gamma-hidroxibutirano (ghb).
EP1325014B1 (en) * 2000-09-22 2012-05-23 JPI Commercial, LLC Gamma-hydroxybutyrate compositions containing carbohydrate carriers
ES2527857T3 (es) 2003-05-08 2015-01-30 Tepha, Inc. Tejidos y fibras médicas de polihidroxialcanoato
ATE556727T1 (de) 2004-08-03 2012-05-15 Tepha Inc Polyhydroxyalkanoate nähte die sich nicht aufrollen
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016094669A1 (en) 2014-12-11 2016-06-16 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
EP4119539A1 (en) 2015-09-23 2023-01-18 XWPharma Ltd. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) * 1980-03-06 1986-11-05 Sigma Tau Ind Farmaceuti Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina

Also Published As

Publication number Publication date
JP2883187B2 (ja) 1999-04-19
JPH03173854A (ja) 1991-07-29
DE69010459T2 (de) 1994-10-20
EP0429403A2 (en) 1991-05-29
HK1005858A1 (en) 1999-01-29
US5547986A (en) 1996-08-20
IT1238344B (it) 1993-07-13
ATE108175T1 (de) 1994-07-15
DE69010459D1 (de) 1994-08-11
IT8948475A0 (it) 1989-10-20
EP0429403A3 (en) 1991-10-02
DK0429403T3 (da) 1994-08-01
EP0429403B1 (en) 1994-07-06
IT8948475A1 (it) 1991-04-20

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