IT1248323B - Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti - Google Patents

Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti

Info

Publication number
IT1248323B
IT1248323B ITRM910333A ITRM910333A IT1248323B IT 1248323 B IT1248323 B IT 1248323B IT RM910333 A ITRM910333 A IT RM910333A IT RM910333 A ITRM910333 A IT RM910333A IT 1248323 B IT1248323 B IT 1248323B
Authority
IT
Italy
Prior art keywords
carnitine
coma
learning
treatment
natural amino
Prior art date
Application number
ITRM910333A
Other languages
English (en)
Inventor
Nicola Fanto'
Mose Santaniello
Giulio Taglialatela
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM910333A0 publication Critical patent/ITRM910333A0/it
Priority to ITRM910333A priority Critical patent/IT1248323B/it
Priority to DK92830224.9T priority patent/DK0514359T3/da
Priority to DE69204737T priority patent/DE69204737T2/de
Priority to ES92830224T priority patent/ES2078019T3/es
Priority to EP92830224A priority patent/EP0514359B1/en
Priority to AT92830224T priority patent/ATE127780T1/de
Priority to CA002068752A priority patent/CA2068752C/en
Priority to US07/883,388 priority patent/US5270472A/en
Priority to JP12372592A priority patent/JP3222195B2/ja
Priority to IE157592A priority patent/IE921575A1/en
Publication of ITRM910333A1 publication Critical patent/ITRM910333A1/it
Application granted granted Critical
Publication of IT1248323B publication Critical patent/IT1248323B/it
Priority to GR950402156T priority patent/GR3017456T3/el
Priority to HK98104938A priority patent/HK1005863A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ammidi di alcanoil L-carnitine di formula generale (I) (FORMULA I) in cui R è alcanoile lineare o ramificato avente da 2 a 8 atomi di carbonio scelto fra acetile, propionile, butirrile, isobutirrile, valerile, isovalerile, esanoile, 1-metilbutirrile, ter-butilacetile, 2-etilbutirrile, 3-metilvalerile, 4-metilvalerile, 2-etilesanoile e 2 propilpentanoile;R' è il residuo monovalente di un amminoacido naturale, e X? è l'anione di un acido farmacologicamente accettabile, sono attivi nell'inibire la degenerazione neuronale, nel trattamento del coma e nel potenziare i processi di apprendimento e memorizzazione.
ITRM910333A 1991-05-16 1991-05-16 Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti IT1248323B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITRM910333A IT1248323B (it) 1991-05-16 1991-05-16 Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
DK92830224.9T DK0514359T3 (da) 1991-05-16 1992-05-14 Alkanoyl-L-carnitin-amider med aminosyrer og farmaceutiske præparater indeholdende disse til fremme af regeneration af nervevæv, inhibering af neuronal degeneration, forøgelse af indlærings- og hukommelsesprocesserne og behandling af coma
DE69204737T DE69204737T2 (de) 1991-05-16 1992-05-14 Alkanoyl L-Carnitin-Amide mit Aminosäuren und diese enthaltende pharmazeutische Zusammensetzungen zur Förderung von Nerven-Regenierung, zur Inhibierung von neuronaler Degeneration zur Verbesserung des Gedächtnisses und des Lernvermögens und zur Behandlung von Koma.
ES92830224T ES2078019T3 (es) 1991-05-16 1992-05-14 Amidas de alcanoil l-carnitina con aminoacidos y composiciones farmaceuticas que las contienen para promover regeneracion del tejido nervioso, inhibir degeneracion neuronal, mejorar el proceso de aprendimiento y memoria y para el tratamiento de coma.
EP92830224A EP0514359B1 (en) 1991-05-16 1992-05-14 Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same, for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory, and for the treatment of coma
AT92830224T ATE127780T1 (de) 1991-05-16 1992-05-14 Alkanoyl l-carnitin-amide mit aminosäuren und diese enthaltende pharmazeutische zusammensetzungen zur förderung von nerven- regenierung, zur inhibierung von neuronaler degeneration zur verbesserung des gedächtnisses und des lernvermögens und zur behandlung von koma.
CA002068752A CA2068752C (en) 1991-05-16 1992-05-15 Alkanoyl l-carnitine amides with aminoacids and pharmaceutical compositions containing same for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma
US07/883,388 US5270472A (en) 1991-05-16 1992-05-15 Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the process of learning and memory and for the treatment of coma
JP12372592A JP3222195B2 (ja) 1991-05-16 1992-05-15 アルカノイル−ｌ−カルニチンアミド誘導体および医薬組成物
IE157592A IE921575A1 (en) 1991-05-16 1992-07-01 Alkanoyl l-carnitine amides with aminoacids and¹pharmaceutical compositions containing same for promoting¹regeneration of the nervous tissue, inhibiting neuronal¹degeneration, enhancing the processes of learning and memory¹for the treatment of coma
GR950402156T GR3017456T3 (en) 1991-05-16 1995-09-21 Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same, for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory, and for the treatment of coma.
HK98104938A HK1005863A1 (en) 1991-05-16 1998-06-05 Alkanoyl l-carnitine amides with aminoacids and pharmaceutical compositions containing same for promoting regeneration of the nervous tissue inhibiting neuronal degeneration enhancing the processes of learning and memory and for the treatment of coma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910333A IT1248323B (it) 1991-05-16 1991-05-16 Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti

Publications (3)

Publication Number Publication Date
ITRM910333A0 ITRM910333A0 (it) 1991-05-16
ITRM910333A1 ITRM910333A1 (it) 1992-11-16
IT1248323B true IT1248323B (it) 1995-01-05

Family

ID=11400146

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910333A IT1248323B (it) 1991-05-16 1991-05-16 Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti

Country Status (12)

Country Link
US (1) US5270472A (it)
EP (1) EP0514359B1 (it)
JP (1) JP3222195B2 (it)
AT (1) ATE127780T1 (it)
CA (1) CA2068752C (it)
DE (1) DE69204737T2 (it)
DK (1) DK0514359T3 (it)
ES (1) ES2078019T3 (it)
GR (1) GR3017456T3 (it)
HK (1) HK1005863A1 (it)
IE (1) IE921575A1 (it)
IT (1) IT1248323B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254314B (it) * 1992-03-27 1995-09-14 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it) 1995-12-15 1997-10-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1291113B1 (it) * 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US5863940A (en) 1997-12-01 1999-01-26 Sigma-Tau Healthscience S.P.A. Medicament and therapeutical method for treating idiopathic asthenozoospermia
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US5958886A (en) * 1998-01-13 1999-09-28 Sigma-Tau Pharmaceuticals, Inc. Carnitine-containing peptides and a method for using the same
ES2210705T5 (es) 1998-03-19 2011-02-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Composición combinada que comprende una l-carnitina o una alcanoil-l-carnitina, un glucosaminoglucano y/o un constituyente del mismo.
IT1306186B1 (it) * 1999-09-03 2001-05-30 Biosalts Srl Sali non igroscopici di principi attivi ad attivita' terapeutica e/onutrizionale e composizioni atte alla somministrazione orale
IT1316998B1 (it) * 2000-03-02 2003-05-26 Sigma Tau Healthscience Spa Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori.
CN1995010B (zh) * 2006-12-29 2012-12-12 辽宁科硕营养科技有限公司 一种合成丙酰左旋肉碱盐酸盐的方法
EP2582368B1 (en) 2010-06-16 2018-05-09 Alfasigma S.p.A. Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue
US9572848B1 (en) 2014-03-26 2017-02-21 Aemes Research L.L.L.P. Composition of matter for sexual dysfunction
CN112851747B (zh) * 2019-11-12 2024-03-05 深圳翰宇药业股份有限公司 一种含季铵碱衍生物修饰的多肽合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione

Also Published As

Publication number Publication date
GR3017456T3 (en) 1995-12-31
US5270472A (en) 1993-12-14
DK0514359T3 (da) 1995-11-13
ITRM910333A0 (it) 1991-05-16
IE921575A1 (en) 1992-11-18
HK1005863A1 (en) 1999-01-29
DE69204737T2 (de) 1996-02-29
EP0514359A3 (en) 1993-03-10
EP0514359A2 (en) 1992-11-19
CA2068752C (en) 2003-01-14
JP3222195B2 (ja) 2001-10-22
DE69204737D1 (de) 1995-10-19
ATE127780T1 (de) 1995-09-15
ES2078019T3 (es) 1995-12-01
EP0514359B1 (en) 1995-09-13
ITRM910333A1 (it) 1992-11-16
JPH0649004A (ja) 1994-02-22
CA2068752A1 (en) 1992-11-17

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