KR880700805A - 기능성 유기 염기를 주제로 하는 뇌질환 치료용 제약 조성물 - Google Patents
기능성 유기 염기를 주제로 하는 뇌질환 치료용 제약 조성물Info
- Publication number
- KR880700805A KR880700805A KR1019870700914A KR870700914A KR880700805A KR 880700805 A KR880700805 A KR 880700805A KR 1019870700914 A KR1019870700914 A KR 1019870700914A KR 870700914 A KR870700914 A KR 870700914A KR 880700805 A KR880700805 A KR 880700805A
- Authority
- KR
- South Korea
- Prior art keywords
- serine
- pharmaceutical composition
- glycerophosphoryl
- alkaline earth
- composition according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 10
- 208000014644 Brain disease Diseases 0.000 title 1
- 150000007530 organic bases Chemical class 0.000 title 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 7
- 230000003412 degenerative effect Effects 0.000 claims 7
- -1 alkali metal salts Chemical class 0.000 claims 6
- 229910052783 alkali metal Inorganic materials 0.000 claims 5
- 210000004556 brain Anatomy 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 159000000007 calcium salts Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 231100000216 vascular lesion Toxicity 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- 유효 성분으로서 글리세로포스포릴-O-세린을 그 자체 또는 알칼리 금속염 또는 알칼리토 금속염의 형태로 함유하는 것을 특징으로 하는 아테롬성 동맥 경화 기재 혈관 병변 및(또는) 노인성 쇠퇴와 같은 다른 종류이 퇴축성 뇌 증후군 치료용 제약 조성물.
- 제1항에 있어서, 유효 성분으로서 글리세로포스폴릴-O-세린을 칼슘염의 형태로 함유하는 제약 조성물.
- 제1항 또는 2항에 있어서, 경구 투여용 제약 조성물.
- 제1항 또는 2항에 있어서, 비경구 투여용 제약 조성물.
- 상기 항 중 어느 하나의 항에 있어서, 단위 복용량 당 글리세로프포릴-O-세린을 그 자체 또는 알칼리금속염 또는 알카리토 금속염의 형태로 25내지 300mg 함유하는 제약 조성물.
- 제5항에 있어서, 글리세로포스포릴-O-세린을 칼슘염의 형태로 함유하는 제약 조성물.
- 상기 항 중 어느 하나의 항에 있어서, 보완 작용 또는 상승 작용을 갖는 다른 약품을 함유하는 제약 조성물.
- 다른 원인, 예를 들면 혈관 병면 및(또는) 노인성 쇠퇴로 인한 퇴축성 뇌 증후군의 치료에 적합한 제약 조성물의 제조에 있어서 글리세로포스포릴-O-세린 및 그의 알칼리 금속염 또는 알칼리토 금속염의 용도.
- 제8항에 있어서, 제약 조성물의 제조에 있어서 글리세로포스포릴-O-세린 칼슘염의 용도.
- 글리세로포스포릴-O-세린과 알칼리 금속 또는 알칼리토금속과의 염.
- 구조식 C6H12NO8PCa의 글리세로포스포릴-0-세린 칼슘염.
- 글리세로포스포릴-O-세린의 수용액을 알칼리금속 또는 알칼리토 금속의 수산화물, 탄산염 또는 중탄산염의 화학양론적 양으로 처리하고, 이와같이 하여 생성된 염을 상기 용액을 증발 건조시키거나 또는 동결 건조시켜서 단리시킴을 특징으로 하는 제10-11항의 염의 제조 방법.
- 각종 원인 예를 들면 퇴축성 원인 또는 뇌혈관 결함으로 인한 퇴축성 뇌 증후군의 치료를 필요로 하는 포유 동물에서 글리세로포스포릴-O-세린 또는 그의 알칼리 금속염 또는 알칼리토 금속염의 유효량을 투여하는 것으로 되는 각종 원인의 퇴축성 뇌 증후군의 치료 방법.
- 각종 원인, 예를 들면 퇴축성 원인 또는 뇌혈관 결함으로 인한 퇴축성 뇌 증후군의 치료를 필요로 하는 포유 동물에게 칼슘염 형태의 글리세로포스포릴-O-세린의 유효량을 투여하는 것으로 되는 각종 원인의 퇴축성 뇌 증후군의 치료 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19382A/86 | 1986-02-12 | ||
| IT8619382A IT1213034B (it) | 1986-02-12 | 1986-02-12 | Composizioni farmaceutiche per la terapia di cerebropatie su base organica e funzionale. |
| PCT/EP1987/000068 WO1987005024A1 (en) | 1986-02-12 | 1987-02-12 | Pharmaceutical compositions for the therapy of cerebropathies on functional and organic base |
| ITPEP87/00068 | 1987-02-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880700805A true KR880700805A (ko) | 1988-04-12 |
| KR940011187B1 KR940011187B1 (ko) | 1994-11-26 |
Family
ID=11157215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019870700914A KR940011187B1 (ko) | 1986-02-12 | 1987-02-12 | 글리세로포스포릴-o-세린의 알칼리 금속 또는 알칼리토 금속염의 제조 방법 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4950776A (ko) |
| EP (1) | EP0256069B1 (ko) |
| JP (1) | JPH0780775B2 (ko) |
| KR (1) | KR940011187B1 (ko) |
| AT (1) | ATE71385T1 (ko) |
| AU (1) | AU601403B2 (ko) |
| CA (1) | CA1291766C (ko) |
| DE (1) | DE3775854D1 (ko) |
| DK (1) | DK169339B1 (ko) |
| FI (1) | FI874450A (ko) |
| HU (1) | HU199148B (ko) |
| IE (1) | IE59283B1 (ko) |
| IL (1) | IL81549A0 (ko) |
| IT (1) | IT1213034B (ko) |
| NO (1) | NO874241L (ko) |
| NZ (1) | NZ219259A (ko) |
| PH (1) | PH24445A (ko) |
| WO (1) | WO1987005024A1 (ko) |
| ZA (1) | ZA871032B (ko) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0348859A1 (en) * | 1988-07-01 | 1990-01-03 | MAGIS FARMACEUTICI S.p.A. | 1,2-di-O-acyl glycero(DI)phosphate of L-carnitine and its derivatives, a process for their preparation and pharmaceutical formulations which contain them |
| IT1230140B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Derivati della serina, loro processo di preparazione e impiego in terapia umana |
| IT1231776B (it) * | 1989-08-07 | 1991-12-21 | Magis Farmaceutici | Processo per preparare i derivati acetilati della l alfa glicerofosforil serina. |
| IT1254471B (it) * | 1992-02-27 | 1995-09-25 | Magis Farmaceutici | Derivati ammidici della (r)-glicerofosforil-(s)-serina o del suo diacil derivato, un processo per la loro preparazione e relative composizioni farmaceutiche per il potenziamento dei processi di apprendimento |
| IT1265647B1 (it) * | 1992-11-18 | 1996-11-22 | Farmin Srl | Composizione farmaceutiche topiche per le allergie respiratorie |
| JP6195949B2 (ja) | 2016-02-26 | 2017-09-13 | 株式会社リケン | ピストンリング |
| CN108558937B (zh) * | 2018-04-19 | 2019-05-24 | 厦门大学 | 一种L-α-甘油磷脂酰丝氨酸及其合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55115824A (en) * | 1979-02-28 | 1980-09-06 | Nippon Shoji Kk | Remedy for clouding of consciousness and sensomobile disorder |
| IT1123142B (it) * | 1979-09-14 | 1986-04-30 | Lpb Ist Farm | Uso di glicerilfosforil derivati nella terapia di dislipemie ed epatiti,e composizioni farmaceutiche relative |
| DE3212387A1 (de) * | 1982-04-02 | 1983-10-13 | Bayer Ag, 5090 Leverkusen | Glycerinphosphatide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US4624852A (en) * | 1983-05-16 | 1986-11-25 | Massachusetts Institute Of Technology | Process and composition for treating neurological disorders and aging |
| JPS6081193A (ja) * | 1983-10-11 | 1985-05-09 | Takeda Chem Ind Ltd | リン脂質 |
| IT1212900B (it) * | 1983-11-17 | 1989-11-30 | Valle Francesco Della | Uso terapeutico della fosfatidilserina in malattie del sistema nervoso centrale senza effetti sulla coagulazione sanguigna |
| IT1199972B (it) * | 1985-05-08 | 1989-01-05 | Lpb Ist Farm | Composizioni farmaceutiche per la terapia di sindromi cerebrali involutive e del decadimento mentale |
-
1986
- 1986-02-12 IT IT8619382A patent/IT1213034B/it active
-
1987
- 1987-02-12 US US07/112,000 patent/US4950776A/en not_active Expired - Fee Related
- 1987-02-12 WO PCT/EP1987/000068 patent/WO1987005024A1/en active IP Right Grant
- 1987-02-12 JP JP62501166A patent/JPH0780775B2/ja not_active Expired - Lifetime
- 1987-02-12 KR KR1019870700914A patent/KR940011187B1/ko not_active IP Right Cessation
- 1987-02-12 PH PH34851A patent/PH24445A/en unknown
- 1987-02-12 IL IL81549A patent/IL81549A0/xx not_active IP Right Cessation
- 1987-02-12 ZA ZA871032A patent/ZA871032B/xx unknown
- 1987-02-12 EP EP87901055A patent/EP0256069B1/en not_active Expired - Lifetime
- 1987-02-12 DE DE8787901055T patent/DE3775854D1/de not_active Expired - Fee Related
- 1987-02-12 AU AU70250/87A patent/AU601403B2/en not_active Ceased
- 1987-02-12 HU HU871033A patent/HU199148B/hu not_active IP Right Cessation
- 1987-02-12 NZ NZ219259A patent/NZ219259A/xx unknown
- 1987-02-12 CA CA000529554A patent/CA1291766C/en not_active Expired - Lifetime
- 1987-02-12 IE IE36187A patent/IE59283B1/en not_active IP Right Cessation
- 1987-02-12 AT AT87901055T patent/ATE71385T1/de not_active IP Right Cessation
- 1987-10-09 FI FI874450A patent/FI874450A/fi not_active IP Right Cessation
- 1987-10-09 NO NO874241A patent/NO874241L/no unknown
- 1987-10-12 DK DK532087A patent/DK169339B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE59283B1 (en) | 1994-02-09 |
| EP0256069A1 (en) | 1988-02-24 |
| DE3775854D1 (de) | 1992-02-20 |
| CA1291766C (en) | 1991-11-05 |
| IL81549A0 (en) | 1987-09-16 |
| NO874241L (no) | 1987-12-09 |
| ATE71385T1 (de) | 1992-01-15 |
| IE870361L (en) | 1987-08-12 |
| EP0256069B1 (en) | 1992-01-08 |
| DK532087D0 (da) | 1987-10-12 |
| JPH0780775B2 (ja) | 1995-08-30 |
| NZ219259A (en) | 1989-04-26 |
| AU601403B2 (en) | 1990-09-13 |
| US4950776A (en) | 1990-08-21 |
| IT1213034B (it) | 1989-12-07 |
| FI874450A0 (fi) | 1987-10-09 |
| DK169339B1 (da) | 1994-10-10 |
| WO1987005024A1 (en) | 1987-08-27 |
| KR940011187B1 (ko) | 1994-11-26 |
| HUT47299A (en) | 1989-02-28 |
| FI874450A (fi) | 1987-10-09 |
| JPS63502893A (ja) | 1988-10-27 |
| AU7025087A (en) | 1987-09-09 |
| IT8619382A0 (it) | 1986-02-12 |
| HU199148B (en) | 1990-01-29 |
| ZA871032B (en) | 1987-08-04 |
| NO874241D0 (no) | 1987-10-09 |
| DK532087A (da) | 1987-10-12 |
| PH24445A (en) | 1990-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| G160 | Decision to publish patent application | ||
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