RU93055870A - Производные бифенила, способ их получения и фармацевтическая композиция для лечения гипертонии и сердечных заболеваний - Google Patents
Производные бифенила, способ их получения и фармацевтическая композиция для лечения гипертонии и сердечных заболеванийInfo
- Publication number
- RU93055870A RU93055870A RU93055870/04A RU93055870A RU93055870A RU 93055870 A RU93055870 A RU 93055870A RU 93055870/04 A RU93055870/04 A RU 93055870/04A RU 93055870 A RU93055870 A RU 93055870A RU 93055870 A RU93055870 A RU 93055870A
- Authority
- RU
- Russia
- Prior art keywords
- hypertension
- treatment
- production
- pharmaceutical composition
- biphenyl derivatives
- Prior art date
Links
- 206010020772 Hypertension Diseases 0.000 title claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title claims 2
- 201000010238 heart disease Diseases 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000015427 Angiotensins Human genes 0.000 claims 1
- 108010064733 Angiotensins Proteins 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Предлагаемые соединения производных бифенила и их фармацевтически приемлемые соли и сложные эфиры обладают способностью ингибировать действие ангиотензина П и могут быть использованы для лечения и профилактики гипертонии и сердечных заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4-337675 | 1992-12-17 | ||
JP33767592 | 1992-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93055870A true RU93055870A (ru) | 1996-09-10 |
RU2109736C1 RU2109736C1 (ru) | 1998-04-27 |
Family
ID=18310901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93055870A RU2109736C1 (ru) | 1992-12-17 | 1993-12-16 | Производные бифенила и способ их получения |
Country Status (21)
Country | Link |
---|---|
US (1) | US5459148A (ru) |
EP (1) | EP0603001B1 (ru) |
JP (1) | JP3501484B2 (ru) |
KR (1) | KR100307057B1 (ru) |
CN (1) | CN1056140C (ru) |
AT (1) | ATE170177T1 (ru) |
AU (1) | AU673862B2 (ru) |
CA (1) | CA2111662C (ru) |
CZ (1) | CZ283315B6 (ru) |
DE (1) | DE69320603T2 (ru) |
DK (1) | DK0603001T3 (ru) |
ES (1) | ES2121063T3 (ru) |
FI (1) | FI108861B (ru) |
HK (1) | HK1011970A1 (ru) |
HU (1) | HU219598B (ru) |
IL (1) | IL108067A (ru) |
NO (1) | NO304429B1 (ru) |
NZ (1) | NZ250505A (ru) |
RU (1) | RU2109736C1 (ru) |
TW (1) | TW259786B (ru) |
ZA (1) | ZA939493B (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
TW215434B (ru) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
WO1995024902A1 (fr) * | 1994-03-16 | 1995-09-21 | Sankyo Company, Limited | Reducteur de tension oculaire |
KR100238012B1 (ko) * | 1995-07-31 | 2000-01-15 | 이구택 | 용접성 및 성형성이 우수한 확관 용기용 냉연 강판의 제조 방법 |
JPH0959277A (ja) * | 1995-08-17 | 1997-03-04 | Green Cross Corp:The | 6−アミノメチル置換キノリン安息香酸類の製造方法 |
KR100241305B1 (ko) * | 1995-11-30 | 2000-03-02 | 이구택 | 내 염산부식성이 우수한 고가공용 고강도 냉연강판의 제조 방법 |
KR100240986B1 (ko) * | 1995-12-05 | 2000-03-02 | 이구택 | 2차 가공취성이 우수한 심가공용 고장력 냉간압연강판의 제조방법 |
KR100411670B1 (ko) * | 1999-06-29 | 2003-12-18 | 주식회사 포스코 | 고성형성 소부경화형 고강도 냉연강판 및 그 제조방법 |
KR100433248B1 (ko) * | 1999-12-28 | 2004-05-27 | 주식회사 포스코 | 가공성 및 내벤트성이 우수한 고가공용 고강도 냉연강판및 그 제조방법 |
WO2002034263A1 (fr) * | 2000-10-25 | 2002-05-02 | Takeda Chemical Industries, Ltd. | Agents preventifs/remedes destines a l'hypertension portale |
KR100470640B1 (ko) * | 2000-11-24 | 2005-03-07 | 주식회사 포스코 | 고강도 소부경화형 냉연강판 및 그 제조방법 |
KR100584755B1 (ko) * | 2001-12-24 | 2006-05-30 | 주식회사 포스코 | 소부경화성을 갖는 프레스성형성이 우수한고강도냉연강판의 제조방법 |
WO2005051929A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | Conversion of aromatic nitriles into tetrazoles |
KR101021828B1 (ko) * | 2004-10-27 | 2011-03-17 | 다이이찌 산쿄 가부시키가이샤 | 2 이상의 치환기를 갖는 벤젠 화합물 |
WO2007047838A2 (en) * | 2005-10-20 | 2007-04-26 | Dr. Reddy's Laboratories Ltd. | Process for preparing olmesartan medoxomil |
KR100711359B1 (ko) * | 2005-12-14 | 2007-04-27 | 주식회사 포스코 | 면내이방성이 우수한 소부경화형 박강판 및 그 제조방법 |
JP2010053435A (ja) * | 2008-08-29 | 2010-03-11 | Showa Denko Kk | 無電解めっき用センシタイジング液および無電解めっき方法 |
CN101921265B (zh) * | 2009-11-25 | 2012-07-04 | 北京理工大学 | 联苯酰胺四唑类化合物、合成方法及用途 |
JP5629380B2 (ja) * | 2010-12-17 | 2014-11-19 | 田辺三菱製薬株式会社 | 連続芳香環式化合物 |
ES2690315T3 (es) | 2012-06-15 | 2018-11-20 | Mitsubishi Tanabe Pharma Corporation | Compuestos de imidazol y triazol como inhibidores de DGAT-1 |
CN104402873A (zh) * | 2014-12-02 | 2015-03-11 | 千辉药业(安徽)有限责任公司 | 一种奥美沙坦酯中间体的制备方法 |
KR102142628B1 (ko) * | 2019-07-30 | 2020-09-14 | 현대오트론 주식회사 | 레졸버 센서의 구동신호를 구현하기 위한 방법 및 이를 위한 장치 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4335040A (en) * | 1966-10-06 | 1982-06-15 | Livingston Labs. | Therapeutic product and method |
JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
DK531479A (da) * | 1979-01-19 | 1980-07-20 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
JPS6019908B2 (ja) * | 1980-04-30 | 1985-05-18 | カネボウ株式会社 | 1,3−ジオキソレン−2−オン誘導体 |
IE802177L (en) * | 1980-10-21 | 1981-05-12 | Takeda Chemical Industries Ltd | Imidazol-5-ylacetic acid derivatives |
US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
US4874867A (en) * | 1987-05-22 | 1989-10-17 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US4870186A (en) * | 1987-05-22 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US5189048A (en) * | 1988-01-07 | 1993-02-23 | E. I. Du Pont De Nemours And Company | Substituted 1,2,3 triazole angiotensin II antagonists |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
US5081127A (en) * | 1988-01-07 | 1992-01-14 | E. I. Du Pont De Nemours And Company | Substituted 1,2,3-triazole angiotensin II antagonists |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5093346A (en) * | 1988-01-07 | 1992-03-03 | E. I. Du Pont De Nemours And Company | Substituted 1,2,4-triazole angiotensin II antagonists |
US5043349A (en) * | 1988-01-07 | 1991-08-27 | E. I. Du Pont De Nemours And Company | Substituted pyrrole angiotensin II antagonists |
US5354867A (en) * | 1988-12-06 | 1994-10-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
CA2016710A1 (en) * | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
GB8911854D0 (en) * | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
IE64514B1 (en) * | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
US5312828A (en) * | 1989-06-14 | 1994-05-17 | Finkelstein Joseph A | Substituted imidazoles having angiotensin II receptor blocking activity |
KR950009860B1 (ko) * | 1989-06-30 | 1995-08-29 | 이. 아이. 듀퐁 드 네모아 앤드 캄파니 | 융합된 환 아릴 치환된 이미다졸과 약제학적으로 허용되는 이의 염, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물 |
KR0163595B1 (ko) * | 1989-06-30 | 1998-12-01 | 미리암디, 메코너헤이 | 치환된 이미다졸 |
JPH0830013B2 (ja) * | 1989-07-28 | 1996-03-27 | 財団法人相模中央化学研究所 | ビアリール化合物の製造方法 |
IE70593B1 (en) * | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
CA2032289A1 (en) * | 1989-12-29 | 1991-06-30 | Joseph A. Finkelstein | Substituted 5-(alkyl) carboxamide imidazoles |
US5140037A (en) * | 1990-03-20 | 1992-08-18 | E. I. Du Pont De Nemours And Company | Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists |
US5039814A (en) * | 1990-05-02 | 1991-08-13 | Merck & Co., Inc. | Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes |
FR2663028B1 (fr) * | 1990-06-08 | 1994-10-14 | Roussel Uclaf | Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
DK0461039T3 (da) * | 1990-06-08 | 1999-06-14 | Hoechst Marion Roussel Inc | Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so |
AU7983691A (en) * | 1990-06-15 | 1992-01-07 | G.D. Searle & Co. | 1h-substituted-imidazo{4,5-d}pyridazine compounds for treatment of cardiovascular disorders |
IL98319A (en) * | 1990-07-05 | 1997-04-15 | Roussel Uclaf | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
DE4023215A1 (de) * | 1990-07-21 | 1992-01-23 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung |
GB9017480D0 (en) * | 1990-08-09 | 1990-09-26 | Ici Plc | Chemical process |
US5089626A (en) * | 1990-08-23 | 1992-02-18 | Merck & Co., Inc. | Process for preparing an angiotensin II antagonist |
IE912956A1 (en) * | 1990-09-10 | 1992-03-11 | Abbott Lab | Angiotensin ii receptor antagonists |
US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
US5260322A (en) * | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
DE4036645A1 (de) * | 1990-11-16 | 1992-05-21 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, deren enthaltende mittel und deren verwendung |
DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
IE914572A1 (en) * | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
IS1756B (is) * | 1991-02-21 | 2000-12-28 | Sankyo Company Limited | Hliðstæðuaðferð til framleiðslu 1-Biphenylmethylimidazole afleiða |
US5236928A (en) * | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
EP0505098A1 (en) * | 1991-03-19 | 1992-09-23 | Merck & Co. Inc. | Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists |
US5177097A (en) * | 1991-07-24 | 1993-01-05 | E. R. Squibb & Sons, Inc. | Acyl amidine and acyl, guanidine substituted biphenyl derivatives |
TW209213B (ru) * | 1991-08-21 | 1993-07-11 | Yamanouchi Pharma Co Ltd | |
US5252753A (en) * | 1991-11-01 | 1993-10-12 | Ortho Pharmaceutical Corporation | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
US5310928A (en) * | 1991-11-18 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Process for preparing biphenyltetrazole compounds |
EP0550313A1 (fr) * | 1991-12-30 | 1993-07-07 | Synthelabo | Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse |
TW215434B (ru) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
ATE199548T1 (de) * | 1992-06-02 | 2001-03-15 | Sankyo Co | 4-carboxyimidazolderivate als angiotensin-ii- antagonisten und ihre therapeutische verwendung |
US5484955A (en) * | 1992-07-06 | 1996-01-16 | Takeda Chemical Industries, Ltd. | Tri-higher alkyl tin azide and its use |
JPH0673029A (ja) * | 1992-07-06 | 1994-03-15 | Takeda Chem Ind Ltd | テトラゾール誘導体の製造法 |
JPH0687833A (ja) * | 1992-07-21 | 1994-03-29 | Sankyo Co Ltd | ビニルイミダゾール誘導体 |
US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
US5266583A (en) * | 1992-09-01 | 1993-11-30 | Merck & Co., Inc. | Angitotensin II antagonist |
AU5449194A (en) * | 1992-10-26 | 1994-05-24 | Merck & Co., Inc. | Combinations of angiotensin-ii receptor antagonists and diuretics |
-
1993
- 1993-12-16 CZ CZ932777A patent/CZ283315B6/cs not_active IP Right Cessation
- 1993-12-16 TW TW082110680A patent/TW259786B/zh active
- 1993-12-16 NO NO934645A patent/NO304429B1/no unknown
- 1993-12-16 CA CA002111662A patent/CA2111662C/en not_active Expired - Fee Related
- 1993-12-16 HU HU9303611A patent/HU219598B/hu not_active IP Right Cessation
- 1993-12-16 JP JP31679593A patent/JP3501484B2/ja not_active Expired - Fee Related
- 1993-12-16 RU RU93055870A patent/RU2109736C1/ru not_active IP Right Cessation
- 1993-12-17 NZ NZ250505A patent/NZ250505A/en unknown
- 1993-12-17 DE DE69320603T patent/DE69320603T2/de not_active Expired - Fee Related
- 1993-12-17 ZA ZA939493A patent/ZA939493B/xx unknown
- 1993-12-17 DK DK93310239T patent/DK0603001T3/da active
- 1993-12-17 EP EP93310239A patent/EP0603001B1/en not_active Expired - Lifetime
- 1993-12-17 IL IL10806793A patent/IL108067A/en not_active IP Right Cessation
- 1993-12-17 AU AU52475/93A patent/AU673862B2/en not_active Ceased
- 1993-12-17 CN CN93119912A patent/CN1056140C/zh not_active Expired - Fee Related
- 1993-12-17 AT AT93310239T patent/ATE170177T1/de not_active IP Right Cessation
- 1993-12-17 KR KR1019930028658A patent/KR100307057B1/ko not_active IP Right Cessation
- 1993-12-17 FI FI935693A patent/FI108861B/fi not_active IP Right Cessation
- 1993-12-17 ES ES93310239T patent/ES2121063T3/es not_active Expired - Lifetime
-
1994
- 1994-10-27 US US08/331,356 patent/US5459148A/en not_active Expired - Fee Related
-
1998
- 1998-12-09 HK HK98113007A patent/HK1011970A1/xx not_active IP Right Cessation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU93055870A (ru) | Производные бифенила, способ их получения и фармацевтическая композиция для лечения гипертонии и сердечных заболеваний | |
RU94013439A (ru) | Гетероциклические соединения, способ их получения, фармацевтическая композиция и способ лечения | |
RU94016393A (ru) | Пептиды, обладающие способностью к стимулированию высвобождения гормона роста, способ получения, фармацевтическая композиция, способ лечения | |
RU93058555A (ru) | Производные хинуклидина, способ их получения, фармацевтическая композиция, способ лечения или профилактики | |
EP0216539A3 (en) | Novel amino acid derivatives | |
EP0200406A3 (en) | Novel amino acid derivatives | |
CA2005986A1 (en) | Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation | |
IE780643L (en) | THERAPEUTIC APPLICATION OF d, 1-CARNITINE DERIVITIVES | |
CA2133998A1 (en) | Treatment of macular degeneration | |
RU94042907A (ru) | Производные имидазопиридина, способ их получения, фармацевтическая композиция и способ ее получения | |
RU93047023A (ru) | Производные имидазола-антагонисты ангиотензина-11, их получение и терапевтическое применение | |
EP0244083A3 (en) | Amino acid derivatives | |
RU93004793A (ru) | Производные хиназолина, способ их получения, фармацевтическая композиция на их основе | |
GB8817015D0 (en) | Method of treatment | |
EP1262182A3 (en) | Methods and compositions for treating hypertension, angina and other disorders using optically pure(-) amlodipine | |
EP0190891A3 (en) | Novel amino acid derivatives | |
EP0451654A3 (en) | Use of n-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation | |
CA2005980A1 (en) | Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation | |
CA2116388A1 (en) | Treatment for viral diseases | |
RU2001118854A (ru) | Оптически активное производное пиридил-4н-1,2,4-оксадиазина и его применение при лечении сосудистых заболеваний | |
NO933091L (no) | Anvendelse av 1-aryl-3-(4-piperidyl)-indolderivater ved behandling av kognitive forstyrrelser | |
RU2005119970A (ru) | Оптически активное производное дигидропиридина | |
RU2001118219A (ru) | Ингибитор ангиогенеза | |
RU92004569A (ru) | Фармацевтический препарат антистрессорного, стресспротекторного и ноотропного действия | |
CA2065889A1 (en) | Increasing the choroidal blood flow |