IT1155813B - Nuova applicazione terapeutica dell'acetil-d i-carnitina e di altri derivati acilati della d- i-carnitina - Google Patents
Nuova applicazione terapeutica dell'acetil-d i-carnitina e di altri derivati acilati della d- i-carnitinaInfo
- Publication number
- IT1155813B IT1155813B IT4789878A IT4789878A IT1155813B IT 1155813 B IT1155813 B IT 1155813B IT 4789878 A IT4789878 A IT 4789878A IT 4789878 A IT4789878 A IT 4789878A IT 1155813 B IT1155813 B IT 1155813B
- Authority
- IT
- Italy
- Prior art keywords
- cardiotropic
- ischaemia
- carnitine
- treating
- compsns
- Prior art date
Links
- 206010002660 Anoxia Diseases 0.000 title abstract 2
- 241000976983 Anoxia Species 0.000 title abstract 2
- 206010021143 Hypoxia Diseases 0.000 title abstract 2
- 230000007953 anoxia Effects 0.000 title abstract 2
- 230000001426 cardiotropic effect Effects 0.000 title abstract 2
- 208000028867 ischemia Diseases 0.000 title abstract 2
- 230000002107 myocardial effect Effects 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical class C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title 1
- 206010003119 arrhythmia Diseases 0.000 title 1
- 230000006793 arrhythmia Effects 0.000 title 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 abstract 2
- 230000000747 cardiac effect Effects 0.000 abstract 2
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 abstract 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N Adrenaline Natural products CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 abstract 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000002339 acetoacetyl group Chemical group O=C([*])C([H])([H])C(=O)C([H])([H])[H] 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 229940102884 adrenalin Drugs 0.000 abstract 1
- 230000002763 arrhythmic effect Effects 0.000 abstract 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005516 coenzyme A Substances 0.000 abstract 1
- 229940093530 coenzyme a Drugs 0.000 abstract 1
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 abstract 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- -1 hydroxybutyryl Chemical group 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 abstract 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4789878A IT1155813B (it) | 1978-02-03 | 1978-02-03 | Nuova applicazione terapeutica dell'acetil-d i-carnitina e di altri derivati acilati della d- i-carnitina |
| AU34598/78A AU518617B2 (en) | 1977-04-29 | 1978-03-30 | Therapeutic application of acetyl-d, 1-carnitine |
| IE643/78A IE46703B1 (en) | 1977-04-29 | 1978-03-31 | Pharmaceutical compositions containing carnitine derivatives |
| GB13769/78A GB1596491A (en) | 1977-04-29 | 1978-04-07 | Pharmaceutical compositions containing carnitine derivatives |
| US05/895,044 US4194006A (en) | 1977-04-29 | 1978-04-10 | Therapeutic application of acetyl-d,l-carnitine and other acyl derivatives of d,l-carnitine |
| DE19782817358 DE2817358A1 (de) | 1977-04-29 | 1978-04-20 | Neue therapeutische anwendung von acylderivaten des d,l-carnitin |
| FR7811863A FR2388556A1 (fr) | 1977-04-29 | 1978-04-21 | Application therapeutique de l'acetyl-carnitine-d,1 et d'autres derives acyliques de la carnitine-d,1 |
| CH460478A CH636268A5 (it) | 1977-04-29 | 1978-04-27 | Composizioni farmaceutiche, contenenti derivati della d,1-carnitina attivi nella terepia delle affezioni cardiache. |
| NLAANVRAGE7804567,A NL188078C (nl) | 1977-04-29 | 1978-04-27 | Farmaceutisch preparaat voor de behandeling van hartarrhytmieen en myocardiale aandoeningen. |
| BE187276A BE866568A (fr) | 1977-04-29 | 1978-04-28 | Compositions therapeutiques contenant des derives de d,1-carnitine et leur utilisation |
| JP5325878A JPS53136523A (en) | 1977-04-29 | 1978-04-28 | Application of calnitine derivatives to medicine |
| KE3223A KE3223A (en) | 1977-04-29 | 1982-07-15 | Pharmaceutical compositions containing carnitine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4789878A IT1155813B (it) | 1978-02-03 | 1978-02-03 | Nuova applicazione terapeutica dell'acetil-d i-carnitina e di altri derivati acilati della d- i-carnitina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7847898A0 IT7847898A0 (it) | 1978-02-03 |
| IT1155813B true IT1155813B (it) | 1987-01-28 |
Family
ID=11263206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT4789878A IT1155813B (it) | 1977-04-29 | 1978-02-03 | Nuova applicazione terapeutica dell'acetil-d i-carnitina e di altri derivati acilati della d- i-carnitina |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1155813B (it) |
-
1978
- 1978-02-03 IT IT4789878A patent/IT1155813B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7847898A0 (it) | 1978-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19961216 |