ES8207128A1 - Procedimiento para preparar carnitinamidas - Google Patents

Procedimiento para preparar carnitinamidas

Info

Publication number
ES8207128A1
ES8207128A1 ES498881A ES498881A ES8207128A1 ES 8207128 A1 ES8207128 A1 ES 8207128A1 ES 498881 A ES498881 A ES 498881A ES 498881 A ES498881 A ES 498881A ES 8207128 A1 ES8207128 A1 ES 8207128A1
Authority
ES
Spain
Prior art keywords
carnitine
optically active
acyl
amides
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498881A
Other languages
English (en)
Other versions
ES498881A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of ES498881A0 publication Critical patent/ES498881A0/es
Publication of ES8207128A1 publication Critical patent/ES8207128A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Abstract

PROCEDIMIENTO PARA PREPARAR CARNITINAMIDAS. CONSISTE EN HACER REACCIONAR UN AMINOACIDO OPTICAMENTE ACTIVO, ESTERIFICADO CON ALCOHOLES ALQUILICOS INFERIORES CON 1 A 4 ATOMOS DE CARBONO, EN UN DISOLVENTE ANHIDRO INERTE, CON UN DERIVADO ACTIVADO DE ACRINITINA O ACILCARNITINA. LA MEZCLA DE AMIDAS DIASTEROISOMERICAS SE RESUELVE EN SUS RESPECTIVOS DIASTEROISOMEROS SEPARADOS, SOMETIENDO LA CITADA MEZCLA A CRISTALIZACION FRACCIONADA CON UNA MEZCLA DE DISOLVENTE-AGENTE PRECIPITANTE ELEGIDO ENTRE ACETONA-ACETATO DE ETILO Y METANOL-ACETONA.
ES498881A 1980-01-29 1981-01-28 Procedimiento para preparar carnitinamidas Expired ES8207128A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47749/80A IT1144077B (it) 1980-01-29 1980-01-29 Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
ES498881A0 ES498881A0 (es) 1982-09-01
ES8207128A1 true ES8207128A1 (es) 1982-09-01

Family

ID=11262265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498881A Expired ES8207128A1 (es) 1980-01-29 1981-01-28 Procedimiento para preparar carnitinamidas

Country Status (10)

Country Link
US (1) US4343947A (es)
JP (1) JPS56110654A (es)
BE (1) BE887112A (es)
CA (1) CA1167453A (es)
CH (1) CH651015A5 (es)
DE (1) DE3100133A1 (es)
ES (1) ES8207128A1 (es)
FR (1) FR2474489A1 (es)
GB (1) GB2068946B (es)
IT (1) IT1144077B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248323B (it) * 1991-05-16 1995-01-05 Sigma Tau Ind Farmaceuti Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
US5958886A (en) * 1998-01-13 1999-09-28 Sigma-Tau Pharmaceuticals, Inc. Carnitine-containing peptides and a method for using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265719A (en) * 1959-12-28 1966-08-09 American Cyanamid Co Betaines
US3979441A (en) * 1969-06-11 1976-09-07 The Lubrizol Corporation Oil-soluble polymers of N-3-aminoalkyl acrylamides, and lubricants containing them
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
US4252802A (en) * 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins

Also Published As

Publication number Publication date
BE887112A (fr) 1981-05-14
GB2068946A (en) 1981-08-19
FR2474489B1 (es) 1984-05-18
GB2068946B (en) 1983-07-13
US4343947A (en) 1982-08-10
ES498881A0 (es) 1982-09-01
JPS56110654A (en) 1981-09-01
IT8047749A0 (it) 1980-01-29
CH651015A5 (it) 1985-08-30
CA1167453A (en) 1984-05-15
IT1144077B (it) 1986-10-29
DE3100133A1 (de) 1981-11-19
JPH034539B2 (es) 1991-01-23
FR2474489A1 (fr) 1981-07-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612