JPS567756A - Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative - Google Patents

Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative

Info

Publication number
JPS567756A
JPS567756A JP8241279A JP8241279A JPS567756A JP S567756 A JPS567756 A JP S567756A JP 8241279 A JP8241279 A JP 8241279A JP 8241279 A JP8241279 A JP 8241279A JP S567756 A JPS567756 A JP S567756A
Authority
JP
Japan
Prior art keywords
methyl
acid derivative
mercaptopropionic acid
optically active
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8241279A
Other languages
Japanese (ja)
Inventor
Naohito Ohashi
Shoji Nagata
Sumimoto Katsube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP8241279A priority Critical patent/JPS567756A/en
Priority to US06/090,857 priority patent/US4297282A/en
Publication of JPS567756A publication Critical patent/JPS567756A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled optically active compound, useful as an intermediate of medicines etc., economically, in an industrial scale, by the optical resolution of a specific DL-α-methyl-β-mercaptopropionic acid derivative using a specific amine as a resolving agent.
CONSTITUTION: A DL-α-methyl-β-mercaptopropionic acid derivative of formula I (R1 is acetyl, lower alkyl, or halogen-substituted benzoyl) and an amine-based optical resolving agent composed of β-(p-chlorophenyl)-α-phenylethylamine of formula II are dissolved in a solvent such as acetonitrile, and left to stand at room temperature, and the precipitated salt is separated. The salt is decomposed by acid treatment, and extracted with a solvent to obtain the objective compound of formula III.
COPYRIGHT: (C)1981,JPO&Japio
JP8241279A 1979-03-02 1979-06-28 Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative Pending JPS567756A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP8241279A JPS567756A (en) 1979-06-28 1979-06-28 Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative
US06/090,857 US4297282A (en) 1979-03-02 1979-11-02 Resolution of mercaptopropionic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8241279A JPS567756A (en) 1979-06-28 1979-06-28 Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative

Publications (1)

Publication Number Publication Date
JPS567756A true JPS567756A (en) 1981-01-27

Family

ID=13773865

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8241279A Pending JPS567756A (en) 1979-03-02 1979-06-28 Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative

Country Status (1)

Country Link
JP (1) JPS567756A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5367091A (en) * 1993-04-16 1994-11-22 Medichem, S.A. Optical resolution of DL-3-acetylthio-2-methylpropionic acid using L-(+)-2-aminobutanol as resolving agent
WO1997049679A1 (en) * 1996-06-27 1997-12-31 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5367091A (en) * 1993-04-16 1994-11-22 Medichem, S.A. Optical resolution of DL-3-acetylthio-2-methylpropionic acid using L-(+)-2-aminobutanol as resolving agent
WO1997049679A1 (en) * 1996-06-27 1997-12-31 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient

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