JPS567756A - Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative - Google Patents
Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivativeInfo
- Publication number
- JPS567756A JPS567756A JP8241279A JP8241279A JPS567756A JP S567756 A JPS567756 A JP S567756A JP 8241279 A JP8241279 A JP 8241279A JP 8241279 A JP8241279 A JP 8241279A JP S567756 A JPS567756 A JP S567756A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- acid derivative
- mercaptopropionic acid
- optically active
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the titled optically active compound, useful as an intermediate of medicines etc., economically, in an industrial scale, by the optical resolution of a specific DL-α-methyl-β-mercaptopropionic acid derivative using a specific amine as a resolving agent.
CONSTITUTION: A DL-α-methyl-β-mercaptopropionic acid derivative of formula I (R1 is acetyl, lower alkyl, or halogen-substituted benzoyl) and an amine-based optical resolving agent composed of β-(p-chlorophenyl)-α-phenylethylamine of formula II are dissolved in a solvent such as acetonitrile, and left to stand at room temperature, and the precipitated salt is separated. The salt is decomposed by acid treatment, and extracted with a solvent to obtain the objective compound of formula III.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8241279A JPS567756A (en) | 1979-06-28 | 1979-06-28 | Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative |
US06/090,857 US4297282A (en) | 1979-03-02 | 1979-11-02 | Resolution of mercaptopropionic acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8241279A JPS567756A (en) | 1979-06-28 | 1979-06-28 | Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS567756A true JPS567756A (en) | 1981-01-27 |
Family
ID=13773865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8241279A Pending JPS567756A (en) | 1979-03-02 | 1979-06-28 | Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS567756A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5367091A (en) * | 1993-04-16 | 1994-11-22 | Medichem, S.A. | Optical resolution of DL-3-acetylthio-2-methylpropionic acid using L-(+)-2-aminobutanol as resolving agent |
WO1997049679A1 (en) * | 1996-06-27 | 1997-12-31 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
-
1979
- 1979-06-28 JP JP8241279A patent/JPS567756A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5367091A (en) * | 1993-04-16 | 1994-11-22 | Medichem, S.A. | Optical resolution of DL-3-acetylthio-2-methylpropionic acid using L-(+)-2-aminobutanol as resolving agent |
WO1997049679A1 (en) * | 1996-06-27 | 1997-12-31 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
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