JPS56110683A - Preparation of optical active epoxysuccinate - Google Patents

Preparation of optical active epoxysuccinate

Info

Publication number
JPS56110683A
JPS56110683A JP1390680A JP1390680A JPS56110683A JP S56110683 A JPS56110683 A JP S56110683A JP 1390680 A JP1390680 A JP 1390680A JP 1390680 A JP1390680 A JP 1390680A JP S56110683 A JPS56110683 A JP S56110683A
Authority
JP
Japan
Prior art keywords
formula
compound shown
antipode
epoxysuccinate
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1390680A
Other languages
Japanese (ja)
Other versions
JPS6365667B2 (en
Inventor
Takehiro Amano
Yoshinari Yoshikawa
Shoichi Ito
Jiro Sawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP1390680A priority Critical patent/JPS56110683A/en
Publication of JPS56110683A publication Critical patent/JPS56110683A/en
Publication of JPS6365667B2 publication Critical patent/JPS6365667B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Catalysts (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic intermediate for a certain physiologically active substance in high purity and in high yield by an easy process, by treating a succinic acid derivative or its antipode with a tertiary amine.
CONSTITUTION: A compound shown by the formula I (R is substitutent group commonly used for the protection of functional group; X is halogen), its antipode is treated with a tertiary amine, preferably triethylamine, to give the titled compound shown by the formula II or its antipode. Especially, the reaction product is only allowed to stand at room temperature for 24hr to give the compound shown by the formula II almost quantitatively. (2S, 3S)-Epoxysuccinate among the compound shown by the formula II is an important synthetic intermediate for N-[N- (L-3-trans-carboxyoxysilane-2-carbonyl)-L-leucyl]agmatine inhibiting an enzyme (CANP) showing extraordinary high activity in the muscle of the affect part of a muscular dystrophy patient.
COPYRIGHT: (C)1981,JPO&Japio
JP1390680A 1980-02-07 1980-02-07 Preparation of optical active epoxysuccinate Granted JPS56110683A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1390680A JPS56110683A (en) 1980-02-07 1980-02-07 Preparation of optical active epoxysuccinate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1390680A JPS56110683A (en) 1980-02-07 1980-02-07 Preparation of optical active epoxysuccinate

Publications (2)

Publication Number Publication Date
JPS56110683A true JPS56110683A (en) 1981-09-01
JPS6365667B2 JPS6365667B2 (en) 1988-12-16

Family

ID=11846208

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1390680A Granted JPS56110683A (en) 1980-02-07 1980-02-07 Preparation of optical active epoxysuccinate

Country Status (1)

Country Link
JP (1) JPS56110683A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126879A (en) * 1982-01-25 1983-07-28 Nippon Chemiphar Co Ltd Optically active piperazine derivative and preventive and remedy for cardiac infarction
US5256803A (en) * 1990-02-21 1993-10-26 Rhone-Poulenc Rorer S.A. Process for the preparation of (2R,3R)-cis)-β-phenylglycidic acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126879A (en) * 1982-01-25 1983-07-28 Nippon Chemiphar Co Ltd Optically active piperazine derivative and preventive and remedy for cardiac infarction
US5256803A (en) * 1990-02-21 1993-10-26 Rhone-Poulenc Rorer S.A. Process for the preparation of (2R,3R)-cis)-β-phenylglycidic acid

Also Published As

Publication number Publication date
JPS6365667B2 (en) 1988-12-16

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