JPS58126879A - Optically active piperazine derivative and preventive and remedy for cardiac infarction - Google Patents

Optically active piperazine derivative and preventive and remedy for cardiac infarction

Info

Publication number
JPS58126879A
JPS58126879A JP57009805A JP980582A JPS58126879A JP S58126879 A JPS58126879 A JP S58126879A JP 57009805 A JP57009805 A JP 57009805A JP 980582 A JP980582 A JP 980582A JP S58126879 A JPS58126879 A JP S58126879A
Authority
JP
Japan
Prior art keywords
optically active
compound
formula
remedy
preventive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP57009805A
Inventor
Toshiro Kamishiro
Koichi Kumakura
Mitsuo Mazaki
Tomoo Mazaki
Takashi Okazoe
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP57009805A priority Critical patent/JPS58126879A/en
Publication of JPS58126879A publication Critical patent/JPS58126879A/en
Application status is Pending legal-status Critical

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/55Synthetic design, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:The optically active oxirane-containing compound of formulaI[R1 is H or ≤4C straight or branched alkyl; R2 is ≤4C straight or branched alkyl, group of formula II (n is integer of 0W3), cinnamyl, diphenylmethyl, 2-pyridyl or 2-pyrimidinyl]or its nontoxic salt.
EXAMPLE: (2R,3R)-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)-piperazin-1- ylcarbonyl}butylcarbamoyl]oxirane-2-carboxylic acid ethyl ester.
USE: Preventive and remedy for cardiac infarction.
PROCESS: The optically active compound of formulaI(R1 is R4) can be prepared e.g. by reacting the compound of formula III (R3 is protecting group), etc. with the compound of formula IV, removing the R3 group from the product, and reacting the resultant compound of formula V with the optically active compound of formula VI (R4 is ≤4C alkyl), etc.
COPYRIGHT: (C)1983,JPO&Japio
JP57009805A 1982-01-25 1982-01-25 Optically active piperazine derivative and preventive and remedy for cardiac infarction Pending JPS58126879A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP57009805A JPS58126879A (en) 1982-01-25 1982-01-25 Optically active piperazine derivative and preventive and remedy for cardiac infarction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57009805A JPS58126879A (en) 1982-01-25 1982-01-25 Optically active piperazine derivative and preventive and remedy for cardiac infarction

Publications (1)

Publication Number Publication Date
JPS58126879A true JPS58126879A (en) 1983-07-28

Family

ID=11730394

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57009805A Pending JPS58126879A (en) 1982-01-25 1982-01-25 Optically active piperazine derivative and preventive and remedy for cardiac infarction

Country Status (1)

Country Link
JP (1) JPS58126879A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507297A (en) * 1981-04-10 1985-03-26 Nippon Chemiphar Co., Ltd. Piperazine derivatives and a medicine containing the same
US5328909A (en) * 1991-06-25 1994-07-12 Mitsubishi Kasei Corporation Cyclopropenone derivatives
US5556853A (en) * 1993-10-29 1996-09-17 Takeda Chemical Industries, Ltd. Epoxysuccinic acid derivatives
WO1999011640A1 (en) * 1997-09-04 1999-03-11 Nippon Chemiphar Co., Ltd. Epoxysuccinamide derivatives
US8183284B2 (en) 2005-07-22 2012-05-22 Warner Chilcott Company, Llc Compositions for reducing the incidence of drug induced arrhythmia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56110683A (en) * 1980-02-07 1981-09-01 Taisho Pharmaceut Co Ltd Preparation of optical active epoxysuccinate
JPS6454349A (en) * 1987-08-26 1989-03-01 Honda Motor Co Ltd Inspecting method for metallic member with fiber-reinforced composite layer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56110683A (en) * 1980-02-07 1981-09-01 Taisho Pharmaceut Co Ltd Preparation of optical active epoxysuccinate
JPS6454349A (en) * 1987-08-26 1989-03-01 Honda Motor Co Ltd Inspecting method for metallic member with fiber-reinforced composite layer

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507297A (en) * 1981-04-10 1985-03-26 Nippon Chemiphar Co., Ltd. Piperazine derivatives and a medicine containing the same
US5328909A (en) * 1991-06-25 1994-07-12 Mitsubishi Kasei Corporation Cyclopropenone derivatives
US5416117A (en) * 1991-06-25 1995-05-16 Mitsubishi Kasei Corporation Cyclopropenone derivatives
US5556853A (en) * 1993-10-29 1996-09-17 Takeda Chemical Industries, Ltd. Epoxysuccinic acid derivatives
WO1999011640A1 (en) * 1997-09-04 1999-03-11 Nippon Chemiphar Co., Ltd. Epoxysuccinamide derivatives
US8183284B2 (en) 2005-07-22 2012-05-22 Warner Chilcott Company, Llc Compositions for reducing the incidence of drug induced arrhythmia

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