KR840003812A - 치료 작용을 갖는 d-2-(6-메톡시-2-나프틸)-프로 피온산 유도체의 제조방법 및 이들을 함유하는 약리학적 조성물 - Google Patents

치료 작용을 갖는 d-2-(6-메톡시-2-나프틸)-프로 피온산 유도체의 제조방법 및 이들을 함유하는 약리학적 조성물 Download PDF

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KR840003812A
KR840003812A KR1019830001037A KR830001037A KR840003812A KR 840003812 A KR840003812 A KR 840003812A KR 1019830001037 A KR1019830001037 A KR 1019830001037A KR 830001037 A KR830001037 A KR 830001037A KR 840003812 A KR840003812 A KR 840003812A
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KR
South Korea
Prior art keywords
methoxy
naphthyl
derivative
acid
group
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KR1019830001037A
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English (en)
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폰키롤리 오스발도
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피에트로
피에트로 이스나트디 에트 콤파니 소시에타 페르 아노니메
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Publication of KR840003812A publication Critical patent/KR840003812A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

치료 작용을 갖는 d-2(6-메톡시-2-나프틸)-프로 피온산 유도체의 제조방법 및 이들을 함유하는 약리학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 4'-카르복시, 6-메톡시, 메틸-2-나프탈렌아세트 아닐리드의 IR 분석 데이타
제2도는 4'-카르복시, 6-메톡시, 메틸-2-나프탈렌아세트 아닐리드의 uv 분석 데이타
제3도는 4'-카르복시, 6-메톡시, 메틸-2-나프탈렌아세트 아닐리드의 NMR 분석 데이타

Claims (11)

  1. 다음 일반식을 갖는 d-2-(6-메톡시-2-나프틸)-프로피온산의 p-아미노벤조산과의 반응 유도체.
    위의 일반식에서, X는 수소, 유기 또는 무기기, 무독성이며 약리학적으로 허용가능한 염기, 유기 아민기 또는 염기성 아미노산기이다.
  2. 4'-카르복시, 6-메톡시-나프틸-2-나프탈렌 아세트아닐리드
  3. (a) d-2-(6-메톡시-2-나프틸)-프로피온산의 반응성 유도체를 제조하는 단계,
    (b) 이 반응성 유도체를 p-아미노-벤조산 또는 기의 유도체와 반응시키는 단계,
    (c) 단계 (b)의 생성물을 무독성이며 약리학적으로 허용 가능한 유기 또는 무기 염기, 유기아민 또는 염기성 아미노산과 반응시키는 단계로 구성됨을 특징으로 하는 제1항의 유도체의 제조방법. .
  4. 제3항에 있어서, 반응성 유도체가 에틸 클로로포름산의 염화물 또는 혼합 무수물임을 특징으로 하는 방법.
  5. 제4항에 있어서, 염화물이 염화티오닐과의 반응에 의해 제조된 것임을 특징으로 하는 방법.
  6. 제3항에 있어서, 단계 (b)가 2성분 용매 혼합물중에서 수행됨을 특징으로 하는 방법.
  7. 제6항에 있어서, 2성분 용매 혼합물이 물과 클로로포름으로 구성됨을 특징으로 하는 방법.
  8. 제3항에 있어서, p-아미노벤조산 유도체가 이들의 알칼리 금속염임을 특징으로 하는 방법.
  9. 제3항에 있어서, 단계 (b)가 그 반응 혼합물에 알칼리 금속의 수산화물을 초기에 가함으로써 수행됨을 특징으로 하는 방법.
  10. 통상의 부형제 및 담체와 함께 활성 성분으로서 제1항에 따르는 유도체를 함유함을 특징으로 하는 항염 작용을 갖는 약리학적 조성물.
  11. 제10항에 있어서, 활성 성분이 4'-카르복스, 6-메톡시, 메틸-2-나프탈렌아세트아닐리드임을 특징으로 하는 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001037A 1982-03-16 1983-03-15 치료 작용을 갖는 d-2-(6-메톡시-2-나프틸)-프로 피온산 유도체의 제조방법 및 이들을 함유하는 약리학적 조성물 KR840003812A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20190A/82 1982-03-16
IT20190/82A IT1150687B (it) 1982-03-16 1982-03-16 Derivati dell'acido d-2-(6-metossi-2-naftil) propionico ad attivita' terapeutica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
KR840003812A true KR840003812A (ko) 1984-10-04

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ID=11164574

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Application Number Title Priority Date Filing Date
KR1019830001037A KR840003812A (ko) 1982-03-16 1983-03-15 치료 작용을 갖는 d-2-(6-메톡시-2-나프틸)-프로 피온산 유도체의 제조방법 및 이들을 함유하는 약리학적 조성물

Country Status (6)

Country Link
KR (1) KR840003812A (ko)
CH (1) CH660480A5 (ko)
DE (1) DE3309258A1 (ko)
ES (1) ES8403860A1 (ko)
FR (1) FR2523577B1 (ko)
IT (1) IT1150687B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505411A1 (fr) * 1981-05-08 1982-11-12 Binder Adam Dispositif de recuperation de l'energie du vent
DE3668450D1 (de) * 1985-03-14 1990-03-01 Smithkline Dauelsberg 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978116A (en) * 1971-11-04 1976-08-31 Syntex Corporation 2-naphthyl acetic acid derivatives and compositions and methods thereof
IT1064700B (it) * 1976-07-28 1985-02-25 Pessina Raffaele Procedimento per la preparazione dell acido d.2.6 metossi 2 naftil profionico
FR2388789A1 (fr) * 1977-04-27 1978-11-24 Seuref Ag Derives d'acide benzoique, leur procede de preparation et leur application therapeutique
FR2416214A1 (fr) * 1978-02-02 1979-08-31 Inst Rech Scient Irs Derives d'acide naphtyl-1 acetique, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
IT1150687B (it) 1986-12-17
CH660480A5 (it) 1987-04-30
FR2523577B1 (fr) 1986-10-31
FR2523577A1 (fr) 1983-09-23
ES520623A0 (es) 1984-04-01
ES8403860A1 (es) 1984-04-01
DE3309258C2 (ko) 1990-10-04
DE3309258A1 (de) 1983-09-22
IT8220190A0 (it) 1982-03-16

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