ATE118217T1 - Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung. - Google Patents
Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung.Info
- Publication number
- ATE118217T1 ATE118217T1 AT90104335T AT90104335T ATE118217T1 AT E118217 T1 ATE118217 T1 AT E118217T1 AT 90104335 T AT90104335 T AT 90104335T AT 90104335 T AT90104335 T AT 90104335T AT E118217 T1 ATE118217 T1 AT E118217T1
- Authority
- AT
- Austria
- Prior art keywords
- sodium
- acetylneuraminate
- trihydrate
- production
- water
- Prior art date
Links
- SGVNUGVAEIADTR-CPSXCUFQSA-M O.O.O.[Na+].CC(=O)N[C@@H]1[C@@H](O)CC(O)(C([O-])=O)O[C@H]1[C@H](O)[C@H](O)CO Chemical compound O.O.O.[Na+].CC(=O)N[C@@H]1[C@@H](O)CC(O)(C([O-])=O)O[C@H]1[C@H](O)[C@H](O)CO SGVNUGVAEIADTR-CPSXCUFQSA-M 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- QKFTYFYIYXTFBX-BKSOAOGQSA-M sodium;(2s,4s,5r,6r)-5-acetamido-2,4-dihydroxy-6-[(1r,2r)-1,2,3-trihydroxypropyl]oxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C([O-])=O)O[C@H]1[C@H](O)[C@H](O)CO QKFTYFYIYXTFBX-BKSOAOGQSA-M 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 150000004684 trihydrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1055388A JP2745059B2 (ja) | 1989-03-08 | 1989-03-08 | Ｎ―アセチルノイラミン酸ナトリウム・三水和物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE118217T1 true ATE118217T1 (de) | 1995-02-15 |
Family
ID=12997127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90104335T ATE118217T1 (de) | 1989-03-08 | 1990-03-07 | Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5231177A (de) |
| EP (1) | EP0386721B1 (de) |
| JP (1) | JP2745059B2 (de) |
| KR (1) | KR0128369B1 (de) |
| CN (1) | CN1026982C (de) |
| AT (1) | ATE118217T1 (de) |
| AU (1) | AU621203B2 (de) |
| CA (1) | CA2011468C (de) |
| DE (1) | DE69016683T2 (de) |
| DK (1) | DK0386721T3 (de) |
| ES (1) | ES2067580T3 (de) |
| FI (1) | FI95267C (de) |
| HU (1) | HU203247B (de) |
| IL (1) | IL93670A (de) |
| NO (1) | NO173701C (de) |
| NZ (1) | NZ232806A (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI291462B (en) * | 2000-04-25 | 2007-12-21 | Daiichi Sankyo Co Ltd | Hydrate crystal of neuraminic acid compound |
| JP5702600B2 (ja) * | 2007-07-03 | 2015-04-15 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | オリゴシアル酸誘導体、製造方法および免疫学的使用 |
| JP5523313B2 (ja) | 2007-07-03 | 2014-06-18 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用 |
| US8999954B2 (en) * | 2007-07-03 | 2015-04-07 | Childern's Hospital & Research Center at Oakland | Inhibitors of polysialic acid de-N-acetylase and methods for using the same |
| EP2960237A1 (de) * | 2011-12-16 | 2015-12-30 | Daiichi Sankyo Company, Limited | Verfahren zur herstellung von neuraminsäurederivaten |
| CN106573950B (zh) * | 2014-07-30 | 2020-09-15 | 协和发酵生化株式会社 | N-乙酰神经氨酸碱金属盐无水物的晶体及其制造方法 |
| EP3252065B1 (de) * | 2015-01-28 | 2020-01-08 | Kyowa Hakko Bio Co., Ltd. | Kristall aus ammonium-n-acetylneuraminat-anhydrat und verfahren zur herstellung davon |
| CN109180749B (zh) * | 2018-10-18 | 2022-04-22 | 中国科学院合肥物质科学研究院 | 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法 |
| CN109265497B (zh) * | 2018-10-18 | 2022-04-19 | 武汉中科光谷绿色生物技术有限公司 | 一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法 |
| CN109232677B (zh) * | 2018-10-18 | 2021-12-28 | 中国科学院合肥物质科学研究院 | 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法 |
| CN110606863B (zh) * | 2019-10-08 | 2023-05-30 | 中国科学院合肥物质科学研究院 | 一种n-乙酰神经氨酸二水合物的制备方法 |
| CN110627849B (zh) * | 2019-10-15 | 2023-02-17 | 中国科学院合肥物质科学研究院 | 一种n-乙酰神经氨酸标准物质的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8002823A (nl) * | 1980-05-14 | 1981-12-16 | Amsterdam Chem Comb | Lactitolmonohydraat, alsmede werkwijze voor het bereiden van kristallijn lactitol. |
| JPS6053039B2 (ja) * | 1981-06-26 | 1985-11-22 | メクト株式会社 | Ｎ−アセチル／イラミン酸誘導体およびその製造方法 |
| AU582758B2 (en) * | 1984-06-28 | 1989-04-13 | Mect Corporation | Sialic acid derivatives, galactose derivatives and method for producing the same |
| JPS61103889A (ja) * | 1984-10-24 | 1986-05-22 | Hayashibara Biochem Lab Inc | 結晶エルロ−ス及びそれを含有する含蜜結晶並びにそれらの製造方法及び用途 |
| JPS6344590A (ja) * | 1986-08-12 | 1988-02-25 | Mect Corp | シアル酸誘導体の製造方法 |
| IT1223398B (it) * | 1987-12-01 | 1990-09-19 | Sirac Spa | Procedimento per la preparazione di lattulosio cristallino ad alta purezza |
| JPH01299294A (ja) * | 1988-05-24 | 1989-12-04 | Mect Corp | ４，８−アンハイドロ−ｎ−アセチルノイラミン酸誘導体 |
| ES2061891T3 (es) * | 1988-11-16 | 1994-12-16 | Nippon Kayaku Kk | Cristales de dihidrato de dihidrocloruro de compuesto de etoposido-2-dimetilamina y un procedimiento para su produccion. |
-
1989
- 1989-03-08 JP JP1055388A patent/JP2745059B2/ja not_active Expired - Fee Related
-
1990
- 1990-03-05 US US07/488,860 patent/US5231177A/en not_active Expired - Lifetime
- 1990-03-06 IL IL9367090A patent/IL93670A/en not_active IP Right Cessation
- 1990-03-06 NZ NZ232806A patent/NZ232806A/xx unknown
- 1990-03-07 ES ES90104335T patent/ES2067580T3/es not_active Expired - Lifetime
- 1990-03-07 HU HU901346A patent/HU203247B/hu not_active IP Right Cessation
- 1990-03-07 KR KR1019900002983A patent/KR0128369B1/ko not_active Expired - Fee Related
- 1990-03-07 CA CA002011468A patent/CA2011468C/en not_active Expired - Fee Related
- 1990-03-07 NO NO901084A patent/NO173701C/no unknown
- 1990-03-07 FI FI901150A patent/FI95267C/fi not_active IP Right Cessation
- 1990-03-07 AT AT90104335T patent/ATE118217T1/de not_active IP Right Cessation
- 1990-03-07 AU AU50776/90A patent/AU621203B2/en not_active Ceased
- 1990-03-07 DE DE69016683T patent/DE69016683T2/de not_active Expired - Fee Related
- 1990-03-07 EP EP90104335A patent/EP0386721B1/de not_active Expired - Lifetime
- 1990-03-07 DK DK90104335.6T patent/DK0386721T3/da active
- 1990-03-08 CN CN90101959A patent/CN1026982C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0386721A1 (de) | 1990-09-12 |
| JPH02235897A (ja) | 1990-09-18 |
| CN1026982C (zh) | 1994-12-14 |
| DK0386721T3 (da) | 1995-07-10 |
| CN1045584A (zh) | 1990-09-26 |
| NO901084D0 (no) | 1990-03-07 |
| KR900014419A (ko) | 1990-10-23 |
| ES2067580T3 (es) | 1995-04-01 |
| AU5077690A (en) | 1990-09-20 |
| CA2011468C (en) | 1996-09-10 |
| NO173701B (no) | 1993-10-11 |
| HUT53117A (en) | 1990-09-28 |
| AU621203B2 (en) | 1992-03-05 |
| JP2745059B2 (ja) | 1998-04-28 |
| DE69016683T2 (de) | 1995-06-08 |
| NO901084L (no) | 1990-09-10 |
| FI95267C (fi) | 1996-01-10 |
| HU203247B (en) | 1991-06-28 |
| EP0386721B1 (de) | 1995-02-08 |
| DE69016683D1 (de) | 1995-03-23 |
| IL93670A (en) | 1994-08-26 |
| FI95267B (fi) | 1995-09-29 |
| FI901150A0 (fi) | 1990-03-07 |
| CA2011468A1 (en) | 1990-09-08 |
| KR0128369B1 (ko) | 1998-04-03 |
| HU901346D0 (en) | 1990-05-28 |
| NO173701C (no) | 1994-01-19 |
| NZ232806A (en) | 1991-10-25 |
| US5231177A (en) | 1993-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK16988A (en) | Process for preparing free-flowing ethylcellulose microcapsules | |
| ATE118217T1 (de) | Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung. | |
| BG92179A (bg) | Метод за получаване на 7-заместена-хепт-6-еноена и -хептаноена киселина и техни производни и междинни съединения | |
| NO874733D0 (no) | Fremgangsmaate ved fremstilling av et salt av diclofenac med en cyklisk organisk base. | |
| DE3767094D1 (de) | Neue naphtalin- und indanderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung. | |
| DE69500481D1 (de) | Verfahren zur Herstellung von N-Chloracetylglutamin | |
| JPS6440467A (en) | Novel substituted diphenylimidazole derivative | |
| DE3781879D1 (de) | Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| HUT47091A (en) | Process for producing tetrahydrobenzthiazols | |
| SE7906681L (sv) | Ftalazonderivat | |
| ES8606871A1 (es) | Un procedimiento de preparacion de amoxicilina sodica | |
| YU226283A (en) | Process for preparing new benzazepine derivatives | |
| JPS567756A (en) | Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative | |
| HK70083A (en) | Process for the preparation of sodium amoxycillin | |
| ES471673A1 (es) | Un procedimiento para la preparacion de amoxicilina de sodiosolida | |
| JPS57197256A (en) | Novel cyclohexanecarboxamide derivative and its preparation | |
| JPS5246027A (en) | Process for preparation of thiolcarbamates | |
| TH5201A (th) | 7-((เมทา-ซับสทิทิวเตค) เฟนิลไกลซีน) 1-คาร์บา-1-ดีไธอะเซฟาโลสพอรินต่างๆ | |
| JPS5422363A (en) | Preparation of thiophene-substituted fatty acid halide | |
| JPS51133291A (en) | Process for preparing 3-metyl-3- trifluoroacetoxycephalosporanic acid derivatives | |
| JPS5266685A (en) | Purification and separarion of 2-keto-l-glonic acid | |
| JPS51133292A (en) | A process for preparing 3- methylenecephalosporanic acid derivatives | |
| JPS53149975A (en) | Preparation of imidazolylbenzophenones | |
| NO904736L (no) | Fremgangsmaate ved separasjon av r og s-2,2-r1, r2-1,3-dioksolan-4-karboksyl-syre. | |
| JPS5268102A (en) | Preparation ofn-acylamino acid derivative solution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |