KR900014419A - N-아세틸뉴라민산 나트륨 삼수화물 및 그의 제조방법 - Google Patents

N-아세틸뉴라민산 나트륨 삼수화물 및 그의 제조방법 Download PDF

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KR900014419A
KR900014419A KR1019900002983A KR900002983A KR900014419A KR 900014419 A KR900014419 A KR 900014419A KR 1019900002983 A KR1019900002983 A KR 1019900002983A KR 900002983 A KR900002983 A KR 900002983A KR 900014419 A KR900014419 A KR 900014419A
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South Korea
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sodium
trihydrate
acetyl
neuranate
acetylneuraminate
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KR1019900002983A
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KR0128369B1 (ko
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긴이찌 사이또오
히데오 미즈
나오가즈 스기야마
시꼬오 미나까와
모도아끼 고또오
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곤도오 야스노리
메꾸또 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

N-아세틸뉴라민산 나트륨 삼수화물 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 X선 결정학 분석에 따라 분자 NANA-Na ·3H2O의 입체구조식을 나타내는 도면이며, 여기에 각 원자의 일련 번호를 또한 나타내었다.

Claims (11)

  1. 다음식으로 표시되는 N-이세틸 뉴라민산 나트륨 ·삼수화물
  2. N-아세틸 뉴라민산 나트륨을 물 또는 유기용매의 혼합물에 용해시키는 단계. 결과된 용액을 방치해두는 단계, N-아세틸 뉴라민산 나트륨 ·삼수화물의 결과된 결정을 침전 및 분리하는 단계 및 분리된 결정을 건조시키는 단계들로 이루어지는 N-아세틸 뉴라민산 나트륨 ·삼수화물의 제조방법.
  3. 제2항에 있어서, N-아세틸 뉴라민산 나트륨 ·삼수화물을 약용매의 첨가에 의해 결정화시키는 것을 특징으로 하는 방법.
  4. 제3항에 있어서, 약용매는 에탄올 또는 에탄올/물 혼합물인 것을 특징으로 하는 방법.
  5. 물에 N-아세틸 뉴라민산 나트륨을 용해시키는 단계, 나트륨염의 수화물의 결정을 성장시키면서 용액을 건조시켜 N-아세틸 뉴라민산 나트륨 ·삼수화물을 얻는 단계로 이루어지는 N-아세틸 뉴라민산 나트륨 ·삼수화물의 제조방법.
  6. 제5항에 있어서, N-아세틸 뉴라민산 나트륨의 수용액을 응축시킨다음 N-아세틸 뉴라민산 나트륨·삼수화물을 침전 및 분리시킨다음 건조시키는 것을 특징으로 하는 방법.
  7. 제1항에 있어서, 공간군P41의 정방정계에 있어서 격자상수 a=7.501(2)Å, b=7.501(2)Å 및 c=29.363(5)A를 갖는 것을 특징으로 하는 N-아세틸 뉴라민산 나트륨·삼수화물.
  8. 제1항에 있어서, C2는 S구조를 가지며, C5는 S구조를 가지며, C6는 R구조를 가지며, C8은 R구조를 갖는 것을 특징으로 하는 N-아세틸 뉴라민산 나트륨·삼수화물.
  9. NANA-Na를 삼수화물형으로 전환시키는 것으로 이루어지는 N-아세틸 뉴라민산 나트륨의 보관방법.
  10. 삼수화물을 생성하기에 충분한 시간동안 고습의 분위기에서 N-아세틸 뉴라민산 나트륨을 보관하는 것으로 이루어지는 N-아세틸 N-아세틸뉴라민산 나트륨을 삼수화물의 제조방법.
  11. 제10항에 있어서, 보관의 단계를 밀봉된 용기에서 수행하는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900002983A 1989-03-08 1990-03-07 N-아세틸뉴라민산 나트륨 삼수화물 KR0128369B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1055388A JP2745059B2 (ja) 1989-03-08 1989-03-08 Ｎ―アセチルノイラミン酸ナトリウム・三水和物
JP1-55388 1989-03-08

Publications (2)

Publication Number Publication Date
KR900014419A true KR900014419A (ko) 1990-10-23
KR0128369B1 KR0128369B1 (ko) 1998-04-03

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KR1019900002983A KR0128369B1 (ko) 1989-03-08 1990-03-07 N-아세틸뉴라민산 나트륨 삼수화물

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US (1) US5231177A (ko)
EP (1) EP0386721B1 (ko)
JP (1) JP2745059B2 (ko)
KR (1) KR0128369B1 (ko)
CN (1) CN1026982C (ko)
AT (1) ATE118217T1 (ko)
AU (1) AU621203B2 (ko)
CA (1) CA2011468C (ko)
DE (1) DE69016683T2 (ko)
DK (1) DK0386721T3 (ko)
ES (1) ES2067580T3 (ko)
FI (1) FI95267C (ko)
HU (1) HU203247B (ko)
IL (1) IL93670A (ko)
NO (1) NO173701C (ko)
NZ (1) NZ232806A (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI291462B (en) 2000-04-25 2007-12-21 Daiichi Sankyo Co Ltd Hydrate crystal of neuraminic acid compound
AU2008272854B2 (en) * 2007-07-03 2014-03-13 Children's Hospital & Research Center At Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
JP5523313B2 (ja) * 2007-07-03 2014-06-18 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用
EP2173759A4 (en) 2007-07-03 2014-01-29 Childrens Hosp & Res Ct Oak OLIGOSIALIC ACID DERIVATIVES, METHODS OF MANUFACTURE AND IMMUNOLOGICAL USES
CA2859296C (en) * 2011-12-16 2016-10-11 Daiichi Sankyo Company, Limited Method for manufacturing neuraminic acid derivatives
US10005808B2 (en) 2014-07-30 2018-06-26 Kyowa Hakko Bio Co., Ltd. Crystal of alkali metal N-acetylneuraminate anhydrate, and process for producing same
CN107207552B (zh) * 2015-01-28 2021-03-26 协和发酵生化株式会社 N-乙酰神经氨酸铵盐无水物的晶体及其制造方法
CN109232677B (zh) * 2018-10-18 2021-12-28 中国科学院合肥物质科学研究院 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法
CN109265497B (zh) * 2018-10-18 2022-04-19 武汉中科光谷绿色生物技术有限公司 一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法
CN109180749B (zh) * 2018-10-18 2022-04-22 中国科学院合肥物质科学研究院 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法
CN110606863B (zh) * 2019-10-08 2023-05-30 中国科学院合肥物质科学研究院 一种n-乙酰神经氨酸二水合物的制备方法
CN110627849B (zh) * 2019-10-15 2023-02-17 中国科学院合肥物质科学研究院 一种n-乙酰神经氨酸标准物质的制备方法

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NL8002823A (nl) * 1980-05-14 1981-12-16 Amsterdam Chem Comb Lactitolmonohydraat, alsmede werkwijze voor het bereiden van kristallijn lactitol.
JPS6053039B2 (ja) * 1981-06-26 1985-11-22 メクト株式会社 Ｎ−アセチル／イラミン酸誘導体およびその製造方法
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
JPS61103889A (ja) * 1984-10-24 1986-05-22 Hayashibara Biochem Lab Inc 結晶エルロ−ス及びそれを含有する含蜜結晶並びにそれらの製造方法及び用途
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EP0369369B1 (en) * 1988-11-16 1994-01-26 Nippon Kayaku Kabushiki Kaisha Dihydrate crystals of etoposide-2-dimethylamino compound hydrochloride and a process for production thereof

Also Published As

Publication number Publication date
HU203247B (en) 1991-06-28
DK0386721T3 (da) 1995-07-10
KR0128369B1 (ko) 1998-04-03
JPH02235897A (ja) 1990-09-18
AU621203B2 (en) 1992-03-05
FI901150A0 (fi) 1990-03-07
US5231177A (en) 1993-07-27
NO173701B (no) 1993-10-11
IL93670A (en) 1994-08-26
JP2745059B2 (ja) 1998-04-28
NO901084D0 (no) 1990-03-07
NO173701C (no) 1994-01-19
FI95267C (fi) 1996-01-10
HUT53117A (en) 1990-09-28
CN1026982C (zh) 1994-12-14
CN1045584A (zh) 1990-09-26
AU5077690A (en) 1990-09-20
EP0386721B1 (en) 1995-02-08
DE69016683T2 (de) 1995-06-08
CA2011468C (en) 1996-09-10
NZ232806A (en) 1991-10-25
ATE118217T1 (de) 1995-02-15
FI95267B (fi) 1995-09-29
DE69016683D1 (de) 1995-03-23
CA2011468A1 (en) 1990-09-08
HU901346D0 (en) 1990-05-28
EP0386721A1 (en) 1990-09-12
NO901084L (no) 1990-09-10
ES2067580T3 (es) 1995-04-01

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