ES8606871A1 - Un procedimiento de preparacion de amoxicilina sodica - Google Patents

Un procedimiento de preparacion de amoxicilina sodica

Info

Publication number
ES8606871A1
ES8606871A1 ES85548089A ES548089A ES8606871A1 ES 8606871 A1 ES8606871 A1 ES 8606871A1 ES 85548089 A ES85548089 A ES 85548089A ES 548089 A ES548089 A ES 548089A ES 8606871 A1 ES8606871 A1 ES 8606871A1
Authority
ES
Spain
Prior art keywords
amoxycillin
sodium
organic solvent
addition
aprotic organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES85548089A
Other languages
English (en)
Other versions
ES548089A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to ES85548089A priority Critical patent/ES8606871A1/es
Publication of ES548089A0 publication Critical patent/ES548089A0/es
Publication of ES8606871A1 publication Critical patent/ES8606871A1/es
Priority to CA000520923A priority patent/CA1272189A/en
Priority to EP86308187A priority patent/EP0220925A1/en
Priority to ZA867982A priority patent/ZA867982B/xx
Priority to AU64233/86A priority patent/AU6423386A/en
Priority to US06/921,105 priority patent/US4737585A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR AMOXICILINA SODICA. COMPRENDE: A) TRATAR A LA SUSPENSION DE AMOXICILINA TRIHIDRATO CON UNA BASE ORGANICA ELEGIDA ENTRE DIETILAMINA Y TRIETILAMINA, EN UNA MEZCLA DE DISOLVENTES FORMADA POR UN ALCOHOL DE BAJO PESO MOLECULAR (METANOL O N-BUTANOL) Y POR UN HIDROCARBURO HALOGENADO (CLORURO DE METILENO O 1,2-DICLOROETANO); B) AÑADIR A LA MEZCLA DE REACCION DE A) SODIO OXALACETATO DE DIETILO, CON AGITACION Y ENTRE 2 Y 15JC; Y C) TRATAR A LA SOLUCION DE B) CON METILETILCETONA O ALCOHOL ISOPROPILICO, PARA PRECIPITAR AMOXICILINA SODICA QUE SE AISLA DE LA SOLUCION POR FILTRACION. SE UTILIZA COMO ANTIBACTERIANO PARA USARLO EN MEDICINA POR VIA PARENTERAL.
ES85548089A 1985-10-21 1985-10-21 Un procedimiento de preparacion de amoxicilina sodica Expired ES8606871A1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES85548089A ES8606871A1 (es) 1985-10-21 1985-10-21 Un procedimiento de preparacion de amoxicilina sodica
CA000520923A CA1272189A (en) 1985-10-21 1986-10-20 Process for the preparation of sodium amoxycillin
EP86308187A EP0220925A1 (en) 1985-10-21 1986-10-21 A process for the preparation of sodium amoxycillin
ZA867982A ZA867982B (en) 1985-10-21 1986-10-21 A process for the preparation of sodium amoxycillin
AU64233/86A AU6423386A (en) 1985-10-21 1986-10-21 Process for the preparation of sodium amoxycillin
US06/921,105 US4737585A (en) 1985-10-21 1986-10-21 Process for the preparation of sodium amoxycillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES85548089A ES8606871A1 (es) 1985-10-21 1985-10-21 Un procedimiento de preparacion de amoxicilina sodica

Publications (2)

Publication Number Publication Date
ES548089A0 ES548089A0 (es) 1986-06-01
ES8606871A1 true ES8606871A1 (es) 1986-06-01

Family

ID=8489994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES85548089A Expired ES8606871A1 (es) 1985-10-21 1985-10-21 Un procedimiento de preparacion de amoxicilina sodica

Country Status (6)

Country Link
US (1) US4737585A (es)
EP (1) EP0220925A1 (es)
AU (1) AU6423386A (es)
CA (1) CA1272189A (es)
ES (1) ES8606871A1 (es)
ZA (1) ZA867982B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255716B (it) * 1992-10-05 1995-11-10 Procedimento per la preparazione di antibiotici beta-lattamici sterili
TW347383B (en) * 1995-10-26 1998-12-11 Biochemie Gmbh A process for the production of a crystalline sodium salt of amoxicillin in ethanol as solvent
IL139736A (en) * 1998-06-01 2004-02-19 Smithkline Beecham Corp Process for making salts of crystalline alkaline metals of amoxicillin
US6878386B1 (en) * 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
MX2012014758A (es) * 2010-06-16 2013-10-01 Vardhman Chemtech Ltd Proceso mejorado para preparar amoxicilina sodica.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3262928A (en) * 1963-03-29 1966-07-26 Bristol Myers Co Process for the production of sodium alpha-aminobenzylpenicillin
GB1286199A (en) * 1970-03-16 1972-08-23 Beecham Group Ltd Penicillins
US3669957A (en) * 1970-04-24 1972-06-13 American Home Prod Process for the preparation of sodium ampicillin
GB1464026A (en) * 1974-09-25 1977-02-09 Beecham Group Ltd Preparation of beta-lactam antibiotics

Also Published As

Publication number Publication date
CA1272189A (en) 1990-07-31
ES548089A0 (es) 1986-06-01
US4737585A (en) 1988-04-12
AU6423386A (en) 1987-04-30
EP0220925A1 (en) 1987-05-06
ZA867982B (en) 1987-07-29

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