ES412203A1 - Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular. - Google Patents
Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular.Info
- Publication number
- ES412203A1 ES412203A1 ES412203A ES412203A ES412203A1 ES 412203 A1 ES412203 A1 ES 412203A1 ES 412203 A ES412203 A ES 412203A ES 412203 A ES412203 A ES 412203A ES 412203 A1 ES412203 A1 ES 412203A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- reacted
- phase
- new
- insufficiencies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Procedimiento para la preparación de nuevos compuestos químicos de acción cardiovascular, caracterizado porque, en una primera fase, se hace reaccionar un amino alcohol de fórmula R- O-CH2-CHOH-CH2-A, con el cloruro de tionilo en un solvente apropiado tal como el cloroformo, para obtener un derivado clorado que, en una segunda fse, se hace reaccionar con una amina de fórmula Ar-CH2-NH-Ar'' previamente sodada por medio de amiduro de sodio, con lo que se obtiene un compuesto que, a título de medicamento, puede ser aplicado al tratamiento de las anoxias miocardiacas, insuficiencias coronarias, angor, infartos de miocardio e insuficiencias cardíacas asociadas a las perturbaciones de la circulación coronaria, a través de las vías oral o rectal y con una posología diaria de 100 a 800 mg. Los cuales nuevos compuestos constituyen una nueva familia de propilaminas que responde a la fórmula general **fórmula** en la cual, como en las anteriores: A, representa un grupo aminado terciario, alifático, cicloalifático o heterocíclico, R, representa bien un resto alquilo inferior, lineal o ramificado, bien un resto aralquilo tal como el bencilo y Ar y Ar'', representan restos aromáticos que puede ser idénticos o diferentes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7207647A FR2174655B1 (es) | 1972-03-06 | 1972-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES412203A1 true ES412203A1 (es) | 1975-12-01 |
Family
ID=9094658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES412203A Expired ES412203A1 (es) | 1972-03-06 | 1973-03-01 | Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular. |
Country Status (12)
Country | Link |
---|---|
US (2) | US3962238A (es) |
JP (1) | JPS4899127A (es) |
BE (1) | BE795735A (es) |
CA (2) | CA1015360A (es) |
CH (1) | CH556815A (es) |
DE (1) | DE2310918C3 (es) |
ES (1) | ES412203A1 (es) |
FR (1) | FR2174655B1 (es) |
GB (1) | GB1377327A (es) |
IL (1) | IL41619A (es) |
NL (1) | NL153190C (es) |
ZA (1) | ZA731411B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2378024A1 (fr) * | 1977-01-25 | 1978-08-18 | Cerm Cent Europ Rech Mauvernay | Nouvelle propylamine substituee, obtention et application |
FR2472567A1 (fr) | 1979-12-28 | 1981-07-03 | Cerm Cent Europ Rech Mauvernay | Ethers de 1- (2-propynyloxy)-2-amino-3-propanol, leur preparation et leur application en therapeutique |
ATE32715T1 (de) * | 1981-12-28 | 1988-03-15 | Carter Wallace | Verfahren zur herstellung von b-((2methylpropoxy)-methyl>-n-phenyl-n-(phenylmethyl - 1-pyrrolidinethanamin. |
US4762934A (en) * | 1982-01-18 | 1988-08-09 | Exxon Research And Engineering Company | Diaminoether compositions |
US4405585A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary aminoether alcohols |
US4417075A (en) * | 1982-01-18 | 1983-11-22 | Exxon Research And Engineering Co. | Di-(Secondary and tertiaryalkylaminoalkoxy)alkanes |
US4405581A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary amino compounds |
US4483833A (en) * | 1982-01-18 | 1984-11-20 | Exxon Research & Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 with heterocyclic tertiary aminoalkanols |
US4508692A (en) * | 1982-01-18 | 1985-04-02 | Exxon Research & Engineering Co. | Process for the selective removal of hydrogen sulfide from gaseous mixtures with strongly basic tertiary amino compounds |
US4471138A (en) * | 1982-01-18 | 1984-09-11 | Exxon Research And Engineering Co. | Severely sterically hindered secondary aminoether alcohols |
US4405811A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Severely sterically hindered tertiary amino compounds |
US4405582A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 using diaminoether solutions |
US4405583A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 using di-severely sterically hindered secondary aminoethers |
US4405580A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 with tertiary amino azabicyclic alcohols |
DK156396C (da) * | 1983-09-27 | 1990-01-08 | Cerm Cent Europ Rech Mauvernay | 2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse |
GB8330197D0 (en) * | 1983-11-11 | 1983-12-21 | Akzo Nv | Ether of n-propanolamine derivative |
AU568704B2 (en) * | 1983-11-11 | 1988-01-07 | Akzo N.V. | Ether of n-propanolamine derivative |
US4758563A (en) * | 1986-02-12 | 1988-07-19 | Mcneilab, Inc. | 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use |
US4727072A (en) * | 1986-02-12 | 1988-02-23 | Mcneilab, Inc. | 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents |
DE3726632A1 (de) * | 1987-08-11 | 1989-05-18 | Boehringer Mannheim Gmbh | 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE3726633A1 (de) * | 1987-08-11 | 1989-02-23 | Boehringer Mannheim Gmbh | Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
US4888335A (en) | 1988-07-25 | 1989-12-19 | Mcneilab, Inc. | 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents |
US5185362A (en) * | 1988-09-14 | 1993-02-09 | Mcneilab, Inc. | Diphenylamine cardiovascular agents, compositions and use |
BR0313593A (pt) | 2002-08-19 | 2005-07-12 | Pfizer Prod Inc | Terapia de combinação para doenças hiperproliferativas |
JP4901474B2 (ja) * | 2003-05-30 | 2012-03-21 | ランバクシー ラボラトリーズ リミテッド | 置換ピロール誘導体 |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
US20060147520A1 (en) * | 2004-07-26 | 2006-07-06 | Curtis Ruegg | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
AU2005308575A1 (en) * | 2004-11-23 | 2006-06-01 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
SG166829A1 (en) * | 2005-11-08 | 2010-12-29 | Ranbaxy Lab Ltd | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
CL2007000667A1 (es) * | 2006-03-14 | 2008-03-14 | Ranbaxi Lab Ltd | Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e |
EP2049102A4 (en) * | 2006-07-14 | 2010-12-22 | Ranbaxy Lab Ltd | POLYMORPHIC FORMS OF AN HMG COA REDUCTASE HEATHER AND USE |
EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
WO2009032286A2 (en) | 2007-09-06 | 2009-03-12 | Nektar Therapeutics Al, Corporation | Oligomer-calcium channel blocker conjugates |
US8883844B2 (en) | 2010-09-24 | 2014-11-11 | Nitrogenix Inc. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
WO2016098128A1 (en) | 2014-12-16 | 2016-06-23 | Council Of Scientific & Industrial Research | Process for the preparation of bepridil |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH268689A (de) * | 1947-07-01 | 1950-05-31 | Spojene Farmaceuticke Z Narodn | Verfahren zur Darstellung eines biologisch wirksamen Phenyläthylendiaminderivates. |
US2600301A (en) * | 1948-06-04 | 1952-06-10 | Smith Kline French Lab | N-substituted-beta halo-ethyl amines |
BE546290A (es) * | 1955-04-09 | |||
GB1219609A (en) * | 1968-07-19 | 1971-01-20 | Koninklijke Pharma Fab Nv | Diphenylmethoxyethylamino derivatives |
-
0
- BE BE795735D patent/BE795735A/xx unknown
-
1972
- 1972-03-06 FR FR7207647A patent/FR2174655B1/fr not_active Expired
-
1973
- 1973-02-20 CH CH270373A patent/CH556815A/fr not_active IP Right Cessation
- 1973-02-26 IL IL41619A patent/IL41619A/en unknown
- 1973-02-27 US US05/336,357 patent/US3962238A/en not_active Expired - Lifetime
- 1973-02-28 ZA ZA731411A patent/ZA731411B/xx unknown
- 1973-03-01 ES ES412203A patent/ES412203A1/es not_active Expired
- 1973-03-01 JP JP48024754A patent/JPS4899127A/ja active Pending
- 1973-03-02 GB GB1037973A patent/GB1377327A/en not_active Expired
- 1973-03-05 DE DE2310918A patent/DE2310918C3/de not_active Expired
- 1973-03-06 CA CA165,544A patent/CA1015360A/fr not_active Expired
- 1973-03-06 NL NL7303117.A patent/NL153190C/xx not_active IP Right Cessation
-
1978
- 1978-05-30 CA CA304,367A patent/CA1048027A/fr not_active Expired
-
1979
- 1979-02-27 US US06/015,752 patent/USRE30577E/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
USRE30577E (en) | 1981-04-14 |
IL41619A0 (en) | 1973-04-30 |
FR2174655B1 (es) | 1975-08-01 |
DE2310918B2 (de) | 1979-10-25 |
DE2310918A1 (de) | 1973-09-20 |
GB1377327A (en) | 1974-12-11 |
DE2310918C3 (de) | 1980-07-03 |
CH556815A (fr) | 1974-12-13 |
BE795735A (fr) | 1973-06-18 |
CA1015360A (fr) | 1977-08-09 |
IL41619A (en) | 1976-05-31 |
FR2174655A1 (es) | 1973-10-19 |
JPS4899127A (es) | 1973-12-15 |
ZA731411B (en) | 1974-04-24 |
CA1048027A (fr) | 1979-02-06 |
NL153190B (nl) | 1977-05-16 |
NL7303117A (es) | 1973-09-10 |
US3962238A (en) | 1976-06-08 |
NL153190C (nl) | 1980-12-15 |
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