KR880009018A - 3-l-피로글루타밀-l-티아졸리딘-4-카르복실산 및 이의 제법 - Google Patents

3-l-피로글루타밀-l-티아졸리딘-4-카르복실산 및 이의 제법 Download PDF

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Publication number
KR880009018A
KR880009018A KR1019880000537A KR880000537A KR880009018A KR 880009018 A KR880009018 A KR 880009018A KR 1019880000537 A KR1019880000537 A KR 1019880000537A KR 880000537 A KR880000537 A KR 880000537A KR 880009018 A KR880009018 A KR 880009018A
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KR
South Korea
Prior art keywords
thiazolidine
compound
pyroglutamyl
carboxylic acid
ester
Prior art date
Application number
KR1019880000537A
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English (en)
Other versions
KR960005167B1 (ko
Inventor
폴리 스테파노
Original Assignee
지오바니 키아리
폴리 인다스트리아 키미카 에스.피.에이.
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Application filed by 지오바니 키아리, 폴리 인다스트리아 키미카 에스.피.에이. filed Critical 지오바니 키아리
Publication of KR880009018A publication Critical patent/KR880009018A/ko
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Publication of KR960005167B1 publication Critical patent/KR960005167B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

내용 없음.

Description

3-L-피로글루타밀-L-티아졸리딘-4-카르복실산 및 이의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기식 (I)의 3-L-피로글루타밀-L-티아졸리딘-4-카르복실산 또는 이의 약학적 허용염.
  2. L-피로글루타민산 또는 이의 산클로라이드의 활성화 에스테르를 L-티아졸리딘-4-카르복실과 반응시켜 제1항의 화합물을 제조하는 방법.
  3. 제2항에 있어서, 이 반응은 0℃에서 염기 또는 물 또는 소다 존재하에 디메틸설폭사이드, 디메틸포름아미드 및 지방족 디알킬아미드 그룹에서 선택된 불활성 용매중에서 수행되는 것을 특징으로 하는 방법.
  4. 제2항 또는 제3항에 있어서, 피로글루타민산의 활성화된 에스테르는 펜타클로로페놀, 2,4,5-트리클로로페놀, N-히드록시-숙신이미드를 갖는 에스테르인 것을 특징으로 하는 방법.
  5. 활성 성분으로서 제1항의 화합물 또는 이의 염들중 하나, 약학적 허용 담체로 구성된 약제 조성물.
  6. 제5항에 있어서, 경구 또는 비경구용 정제, 캡슐, 피아정제, 그래뉼 또는 용액형태인 조성물.
  7. 약제로서 사용되는 제1항의 화합물.
  8. 면역 자극, 항독성, 소염, 항산화성, 항노화성 작용등의 약제에 제1항의 화합물 또는 이들 염중의 하나를 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000537A 1987-01-26 1988-01-25 3-l-피로글루타밀-l-티아졸리딘-4-카르복실산 및 그 제조 방법 KR960005167B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT19165A/87 1987-01-26
IT19165/87A IT1202426B (it) 1987-01-26 1987-01-26 Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono

Publications (2)

Publication Number Publication Date
KR880009018A true KR880009018A (ko) 1988-09-13
KR960005167B1 KR960005167B1 (ko) 1996-04-22

Family

ID=11155438

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880000537A KR960005167B1 (ko) 1987-01-26 1988-01-25 3-l-피로글루타밀-l-티아졸리딘-4-카르복실산 및 그 제조 방법

Country Status (19)

Country Link
US (1) US4839387A (ko)
EP (1) EP0276752B1 (ko)
JP (1) JPS63201187A (ko)
KR (1) KR960005167B1 (ko)
AT (1) ATE67212T1 (ko)
AU (1) AU613890B2 (ko)
CA (1) CA1326029C (ko)
DE (2) DE276752T1 (ko)
DK (1) DK171789B1 (ko)
ES (1) ES2003856T3 (ko)
FI (1) FI89369C (ko)
GR (2) GR880300151T1 (ko)
HU (1) HU202867B (ko)
IE (1) IE60185B1 (ko)
IL (1) IL85102A (ko)
IT (1) IT1202426B (ko)
NO (1) NO170686C (ko)
NZ (1) NZ223287A (ko)
ZA (1) ZA88379B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230706B (it) * 1989-02-10 1991-10-29 Poli Ind Chimica Spa Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
IT1239029B (it) * 1989-10-12 1993-09-20 Poli Ind Chimica Spa Processo per la preparazione dell'acido 3-(l-piroglutamil)-l- tiazolidin-4-carbossilico e suoi derivati.
IT1237998B (it) * 1990-01-23 1993-06-21 Poli Ind Chimica Spa Acido 3-l-(5-tioxo-l-prolil)tiazolidin-4-carbossilico e derivati, loro preparazione e composizioni farmaceutiche che li contengono
IT1240353B (it) * 1990-03-30 1993-12-07 Poli Ind Chimica Spa Formulazioni liposomiali di farmaci immunomodulatori per applicazionelocale ed aerosolica
ES2092539T3 (es) * 1991-01-10 1996-12-01 Transcend Therapeutics Inc Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares.
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
IT1244548B (it) * 1991-02-06 1994-07-15 Poli Ind Chimica Spa Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche
FR2675692A1 (fr) * 1991-04-24 1992-10-30 Oreal Systeme anti-oxydant contenant du pyrrolidone carboxylate de lysine et/ou du pyrrolidone carboxylate d'arginine soit seul soit associe a un derive phenolique et son utilisation en cosmetique.
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
IT1264446B1 (it) * 1993-05-14 1996-09-23 Yason Srl Acido 3 (n-(2-mercapto-propionil-ammino-acetil))-tetraidrotiazolil-4- carbossilico come agente antiinfiammatorio e immunostimolante
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
IT1270017B (it) * 1994-09-27 1997-04-16 Poli Ind Chimica Spa "sintesi quantitativa dell'acido 3-(l-piroglutamil)-l-tiazolidin-4- carbossilico e suoi derivati"
DE19711053C2 (de) * 1997-03-03 1999-09-02 Rommelspacher Kombinationspräparat aus 2-Methyl-thiazolidin-2,4-dicarbonsäure und Paracetamol
CN104059106B (zh) * 2014-06-27 2017-02-15 魏景芬 一种磷酸糖醇类四氢噻唑‑4‑羧酸化合物的制备方法
CN104059107A (zh) * 2014-06-27 2014-09-24 魏景芬 一种磷酸糖醇类四氢噻唑-4-羧酸化合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959248A (en) * 1974-04-03 1976-05-25 Merck & Co., Inc. Analogs of thyrotropin-releasing hormone
US4085954A (en) * 1974-06-03 1978-04-25 Thompson Omer A Slat assembly for chain link fence
GB1492640A (en) * 1975-07-08 1977-11-23 Ucb Sa L-pyroglutamyl-l-prolinamide
HU180926B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem

Also Published As

Publication number Publication date
AU613890B2 (en) 1991-08-15
IL85102A (en) 1993-02-21
IL85102A0 (en) 1988-06-30
DK32288A (da) 1988-07-27
US4839387A (en) 1989-06-13
ATE67212T1 (de) 1991-09-15
ES2003856T3 (es) 1992-05-01
GR3003060T3 (en) 1993-02-17
HU202867B (en) 1991-04-29
EP0276752A1 (en) 1988-08-03
NO880332D0 (no) 1988-01-26
FI880324A0 (fi) 1988-01-25
KR960005167B1 (ko) 1996-04-22
FI880324A (fi) 1988-07-27
ZA88379B (en) 1988-07-05
DE3864691D1 (de) 1991-10-17
FI89369B (fi) 1993-06-15
NO170686C (no) 1992-11-18
EP0276752B1 (en) 1991-09-11
AU1067388A (en) 1988-07-28
NO880332L (no) 1988-07-27
IE880178L (en) 1988-07-26
DK171789B1 (da) 1997-05-26
HUT50338A (en) 1990-01-29
DK32288D0 (da) 1988-01-25
JPH0515713B2 (ko) 1993-03-02
GR880300151T1 (en) 1989-01-31
JPS63201187A (ja) 1988-08-19
DE276752T1 (de) 1989-01-05
FI89369C (fi) 1993-09-27
NZ223287A (en) 1990-06-26
ES2003856A4 (es) 1988-12-01
IE60185B1 (en) 1994-06-15
CA1326029C (en) 1994-01-11
IT8719165A0 (it) 1987-01-26
IT1202426B (it) 1989-02-09
NO170686B (no) 1992-08-10

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