IT1156840B - Acil derivati della carnitina - Google Patents

Acil derivati della carnitina

Info

Publication number
IT1156840B
IT1156840B IT50065/78A IT5006578A IT1156840B IT 1156840 B IT1156840 B IT 1156840B IT 50065/78 A IT50065/78 A IT 50065/78A IT 5006578 A IT5006578 A IT 5006578A IT 1156840 B IT1156840 B IT 1156840B
Authority
IT
Italy
Prior art keywords
acil
carnitine
derivatives
acil derivatives
Prior art date
Application number
IT50065/78A
Other languages
English (en)
Other versions
IT7850065A0 (it
Inventor
Witt Paolo De
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT7850065A0 publication Critical patent/IT7850065A0/it
Priority to IT50065/78A priority Critical patent/IT1156840B/it
Priority to CH595679A priority patent/CH640824A5/it
Priority to NO792137A priority patent/NO149733C/no
Priority to IL57662A priority patent/IL57662A/xx
Priority to SE7905593A priority patent/SE446334B/sv
Priority to GR59434A priority patent/GR67648B/el
Priority to GB7922194A priority patent/GB2028826B/en
Priority to DK270079A priority patent/DK148300C/da
Priority to AU48384/79A priority patent/AU526995B2/en
Priority to DE19792925945 priority patent/DE2925945A1/de
Priority to BE0/195998A priority patent/BE877310A/xx
Priority to LU81428A priority patent/LU81428A1/xx
Priority to JP8196379A priority patent/JPS5543065A/ja
Priority to FR7916590A priority patent/FR2429776A1/fr
Priority to CA000330724A priority patent/CA1145765A/en
Priority to AT0449679A priority patent/AT375335B/de
Priority to ES482097A priority patent/ES482097A1/es
Priority to NL7905015A priority patent/NL7905015A/nl
Priority to IE1235/79A priority patent/IE48652B1/en
Priority to US06/334,604 priority patent/US4401827A/en
Application granted granted Critical
Publication of IT1156840B publication Critical patent/IT1156840B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
IT50065/78A 1978-06-27 1978-06-27 Acil derivati della carnitina IT1156840B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT50065/78A IT1156840B (it) 1978-06-27 1978-06-27 Acil derivati della carnitina
CH595679A CH640824A5 (it) 1978-06-27 1979-06-26 Acil-derivati della carnitina e procedimento per la loro preparazione.
NO792137A NO149733C (no) 1978-06-27 1979-06-26 Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive acylderivater av carnitin
IL57662A IL57662A (en) 1978-06-27 1979-06-26 Acyl-esters of carnitine,process for their preparation and pharmaceutical compositions comprising them
SE7905593A SE446334B (sv) 1978-06-27 1979-06-26 Acylderivat av karnitin, forfarande for framstellning derav samt farmaceutisk komposition innehallande nemnda forening
GR59434A GR67648B (it) 1978-06-27 1979-06-26
GB7922194A GB2028826B (en) 1978-06-27 1979-06-26 Acyl-derivatives of carnitine and process for their preparation
DK270079A DK148300C (da) 1978-06-27 1979-06-26 Analogifremgangsmaade til fremstilling af acylderivater af carnitin
AU48384/79A AU526995B2 (en) 1978-06-27 1979-06-26 Acyl-derivatives of carnitine
BE0/195998A BE877310A (fr) 1978-06-27 1979-06-27 Nouveaux derives acyles de carnitine et leur preparation
DE19792925945 DE2925945A1 (de) 1978-06-27 1979-06-27 Acylderivate von carnitin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
LU81428A LU81428A1 (fr) 1978-06-27 1979-06-27 Nouveaux derives acyles de carnitine et leur procede de preparation
JP8196379A JPS5543065A (en) 1978-06-27 1979-06-27 Acyl derivative of carnitine and its manufacture
FR7916590A FR2429776A1 (fr) 1978-06-27 1979-06-27 Nouveaux derives acyles de carnitine, leur procede de preparation et leur application en therapeutique
CA000330724A CA1145765A (en) 1978-06-27 1979-06-27 Acyl-derivatives of carnitine and process for their preparation
AT0449679A AT375335B (de) 1978-06-27 1979-06-27 Verfahren zur herstellung von neuen acylderivaten von carnitin
ES482097A ES482097A1 (es) 1978-06-27 1979-06-27 Procedimiento para preparar derivados acilicos de carnitina.
NL7905015A NL7905015A (nl) 1978-06-27 1979-06-27 Nieuwe acylderivaten van carnitine en werkwijzen ter bereiding ervan.
IE1235/79A IE48652B1 (en) 1978-06-27 1979-08-08 Novel acyl-derivatives of carnitine and process for their preparation
US06/334,604 US4401827A (en) 1978-06-27 1981-12-28 Novel acyl-derivatives of carnitine and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT50065/78A IT1156840B (it) 1978-06-27 1978-06-27 Acil derivati della carnitina

Publications (2)

Publication Number Publication Date
IT7850065A0 IT7850065A0 (it) 1978-06-27
IT1156840B true IT1156840B (it) 1987-02-04

Family

ID=11272207

Family Applications (1)

Application Number Title Priority Date Filing Date
IT50065/78A IT1156840B (it) 1978-06-27 1978-06-27 Acil derivati della carnitina

Country Status (20)

Country Link
US (1) US4401827A (it)
JP (1) JPS5543065A (it)
AT (1) AT375335B (it)
AU (1) AU526995B2 (it)
BE (1) BE877310A (it)
CA (1) CA1145765A (it)
CH (1) CH640824A5 (it)
DE (1) DE2925945A1 (it)
DK (1) DK148300C (it)
ES (1) ES482097A1 (it)
FR (1) FR2429776A1 (it)
GB (1) GB2028826B (it)
GR (1) GR67648B (it)
IE (1) IE48652B1 (it)
IL (1) IL57662A (it)
IT (1) IT1156840B (it)
LU (1) LU81428A1 (it)
NL (1) NL7905015A (it)
NO (1) NO149733C (it)
SE (1) SE446334B (it)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145362B (it) * 1980-03-06 1986-11-05 Sigma Tau Ind Farmaceuti Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1145371B (it) * 1980-05-30 1986-11-05 Sigma Tau Ind Farmaceuti Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1170862B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT8322185V0 (it) * 1983-06-22 1983-06-22 Victor Wassilieff Dispositivo di chiusura per contenitori di fluidi.
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
US4742081A (en) * 1986-01-06 1988-05-03 Alfred Stracher Carnitine coupled pharmaceutical agents
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
IT1208753B (it) * 1986-07-02 1989-07-10 Sigma Tau Ind Farmaceuti L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
JPH0662521B2 (ja) * 1988-02-24 1994-08-17 日東紡績株式会社 新規コリン誘導体及びそれを用いた血清コリンエステラーゼ活性測定法
IT1240790B (it) * 1990-03-06 1993-12-17 Sigma Tau Ind Farmaceuti Alfa-ammino-omega-alchiltioacilcarnitine e composizioni farmaceutiche contenenti tali composti ad attivita' sul sistema cardiovascolare.
CH679856A5 (it) * 1990-07-04 1992-04-30 Lonza Ag
US20040034091A1 (en) * 1991-01-29 2004-02-19 Sigma Tau Industrie Farmaceutiche Riunite S.P.A. Derivative of dicarboxylic acids having six to twelve carbon atoms and use of these derivatives and dicarboxylic acids alone in the preparation of pharmaceutical compositions for enteral and parenteral nutrition
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1274156B (it) * 1994-09-08 1997-07-15 Avantgarde Spa "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee"
US6417231B1 (en) 1996-12-23 2002-07-09 Frank L. Greenway Method and composition for delivering therapeutically effective amounts of pyruvate to a mammal
WO2001021208A1 (en) 1999-09-23 2001-03-29 Juvenon Corporation Nutritional supplement for increased energy and stamina
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
WO2001032168A1 (en) 1999-11-03 2001-05-10 Juvenon, Inc. Method of treating benign forgetfulness
DE10133200A1 (de) * 2001-07-07 2003-01-23 Beiersdorf Ag Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
JP5047507B2 (ja) * 2005-09-30 2012-10-10 昭和電工株式会社 カルニチン誘導体及びその塩、皮膚外用剤ならびに化粧料
US7842726B2 (en) 2005-09-30 2010-11-30 Showa Denko K.K. Carnitine derivative, salt thereof, external skin preparation and cosmetic material
JP6473352B2 (ja) * 2015-03-10 2019-02-20 利幸 糸井 虚血性疾患治療薬

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE277963C (it) *
DE719891C (de) * 1938-12-08 1942-04-21 Dr Erich Strack Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins
FR1108125A (fr) * 1953-05-08 1956-01-09 Laboratoires Labaz Soc D Procédé de préparation d'un dérivé stable de la carnitine
BE700864A (it) * 1967-07-03 1967-12-18
US3624887A (en) * 1970-03-02 1971-12-07 Bunker Ramo Pin and socket removal tool
JPS531812B2 (it) * 1972-12-07 1978-01-23
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine

Also Published As

Publication number Publication date
DK148300B (da) 1985-06-03
JPS5543065A (en) 1980-03-26
NO149733B (no) 1984-03-05
IT7850065A0 (it) 1978-06-27
JPH0211579B2 (it) 1990-03-14
BE877310A (fr) 1979-10-15
US4401827A (en) 1983-08-30
IE791235L (en) 1979-12-27
IE48652B1 (en) 1985-04-03
GB2028826B (en) 1982-11-03
SE446334B (sv) 1986-09-01
IL57662A0 (en) 1979-10-31
CA1145765A (en) 1983-05-03
CH640824A5 (it) 1984-01-31
DK270079A (da) 1979-12-28
AT375335B (de) 1984-07-25
FR2429776A1 (fr) 1980-01-25
NO149733C (no) 1984-06-13
NO792137L (no) 1979-12-28
DE2925945A1 (de) 1980-01-10
IL57662A (en) 1983-12-30
AU526995B2 (en) 1983-02-10
FR2429776B1 (it) 1982-11-12
ATA449679A (de) 1983-12-15
LU81428A1 (fr) 1979-09-12
GR67648B (it) 1981-09-01
SE7905593L (sv) 1979-12-28
AU4838479A (en) 1980-01-03
DK148300C (da) 1985-11-11
GB2028826A (en) 1980-03-12
NL7905015A (nl) 1980-01-02
DE2925945C2 (it) 1991-06-27
ES482097A1 (es) 1980-08-01

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970515