ATA449679A - Verfahren zur herstellung von neuen acylderivaten von carnitin - Google Patents
Verfahren zur herstellung von neuen acylderivaten von carnitinInfo
- Publication number
- ATA449679A ATA449679A AT0449679A AT449679A ATA449679A AT A449679 A ATA449679 A AT A449679A AT 0449679 A AT0449679 A AT 0449679A AT 449679 A AT449679 A AT 449679A AT A449679 A ATA449679 A AT A449679A
- Authority
- AT
- Austria
- Prior art keywords
- carnitin
- acyl derivatives
- producing new
- new acyl
- producing
- Prior art date
Links
- PHIQHXFUZVPYII-LURJTMIESA-O (S)-carnitinium Chemical compound C[N+](C)(C)C[C@@H](O)CC(O)=O PHIQHXFUZVPYII-LURJTMIESA-O 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT50065/78A IT1156840B (it) | 1978-06-27 | 1978-06-27 | Acil derivati della carnitina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA449679A true ATA449679A (de) | 1983-12-15 |
| AT375335B AT375335B (de) | 1984-07-25 |
Family
ID=11272207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0449679A AT375335B (de) | 1978-06-27 | 1979-06-27 | Verfahren zur herstellung von neuen acylderivaten von carnitin |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4401827A (de) |
| JP (1) | JPS5543065A (de) |
| AT (1) | AT375335B (de) |
| AU (1) | AU526995B2 (de) |
| BE (1) | BE877310A (de) |
| CA (1) | CA1145765A (de) |
| CH (1) | CH640824A5 (de) |
| DE (1) | DE2925945A1 (de) |
| DK (1) | DK148300C (de) |
| ES (1) | ES482097A1 (de) |
| FR (1) | FR2429776A1 (de) |
| GB (1) | GB2028826B (de) |
| GR (1) | GR67648B (de) |
| IE (1) | IE48652B1 (de) |
| IL (1) | IL57662A (de) |
| IT (1) | IT1156840B (de) |
| LU (1) | LU81428A1 (de) |
| NL (1) | NL7905015A (de) |
| NO (1) | NO149733C (de) |
| SE (1) | SE446334B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1145362B (it) * | 1980-03-06 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
| IT1147079B (it) * | 1980-05-30 | 1986-11-19 | Sigma Tau Ind Farmacuetiche Ri | Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono |
| IT1145371B (it) * | 1980-05-30 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono |
| IT1170862B (it) * | 1981-03-31 | 1987-06-03 | Sigma Tau Ind Farmaceuti | Mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico |
| IT8322185V0 (it) * | 1983-06-22 | 1983-06-22 | Victor Wassilieff | Dispositivo di chiusura per contenitori di fluidi. |
| IT1209564B (it) * | 1984-06-29 | 1989-08-30 | Magis Farmaceutici | Derivati della l-carnitina o di l-acil carnitina. |
| US5008288A (en) * | 1986-01-06 | 1991-04-16 | Alfred Stracher | Carnitine directed pharmaceutical agents |
| US4866040A (en) * | 1986-01-06 | 1989-09-12 | Alfred Stracher | Aminocarnitine directed pharmaceutical agents |
| US4742081A (en) * | 1986-01-06 | 1988-05-03 | Alfred Stracher | Carnitine coupled pharmaceutical agents |
| IT1208753B (it) * | 1986-07-02 | 1989-07-10 | Sigma Tau Ind Farmaceuti | L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono |
| JPH0662521B2 (ja) * | 1988-02-24 | 1994-08-17 | 日東紡績株式会社 | 新規コリン誘導体及びそれを用いた血清コリンエステラーゼ活性測定法 |
| IT1240790B (it) * | 1990-03-06 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Alfa-ammino-omega-alchiltioacilcarnitine e composizioni farmaceutiche contenenti tali composti ad attivita' sul sistema cardiovascolare. |
| CH679856A5 (de) * | 1990-07-04 | 1992-04-30 | Lonza Ag | |
| US20040034091A1 (en) * | 1991-01-29 | 2004-02-19 | Sigma Tau Industrie Farmaceutiche Riunite S.P.A. | Derivative of dicarboxylic acids having six to twelve carbon atoms and use of these derivatives and dicarboxylic acids alone in the preparation of pharmaceutical compositions for enteral and parenteral nutrition |
| IT1261688B (it) * | 1993-05-28 | 1996-05-29 | Avantgarde Spa | Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
| IT1274156B (it) * | 1994-09-08 | 1997-07-15 | Avantgarde Spa | "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee" |
| US6417231B1 (en) | 1996-12-23 | 2002-07-09 | Frank L. Greenway | Method and composition for delivering therapeutically effective amounts of pyruvate to a mammal |
| WO2001021208A1 (en) | 1999-09-23 | 2001-03-29 | Juvenon Corporation | Nutritional supplement for increased energy and stamina |
| US6562869B1 (en) | 1999-09-23 | 2003-05-13 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
| WO2001032168A1 (en) | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
| DE10133200A1 (de) * | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut |
| JP5047507B2 (ja) * | 2005-09-30 | 2012-10-10 | 昭和電工株式会社 | カルニチン誘導体及びその塩、皮膚外用剤ならびに化粧料 |
| US7842726B2 (en) | 2005-09-30 | 2010-11-30 | Showa Denko K.K. | Carnitine derivative, salt thereof, external skin preparation and cosmetic material |
| JP6473352B2 (ja) * | 2015-03-10 | 2019-02-20 | 利幸 糸井 | 虚血性疾患治療薬 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE277963C (de) * | ||||
| DE719891C (de) * | 1938-12-08 | 1942-04-21 | Dr Erich Strack | Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins |
| FR1108125A (fr) * | 1953-05-08 | 1956-01-09 | Laboratoires Labaz Soc D | Procédé de préparation d'un dérivé stable de la carnitine |
| BE700864A (de) * | 1967-07-03 | 1967-12-18 | ||
| US3624887A (en) * | 1970-03-02 | 1971-12-07 | Bunker Ramo | Pin and socket removal tool |
| JPS531812B2 (de) * | 1972-12-07 | 1978-01-23 | ||
| AU518617B2 (en) * | 1977-04-29 | 1981-10-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Therapeutic application of acetyl-d, 1-carnitine |
-
1978
- 1978-06-27 IT IT50065/78A patent/IT1156840B/it active
-
1979
- 1979-06-26 GR GR59434A patent/GR67648B/el unknown
- 1979-06-26 CH CH595679A patent/CH640824A5/it not_active IP Right Cessation
- 1979-06-26 DK DK270079A patent/DK148300C/da not_active IP Right Cessation
- 1979-06-26 SE SE7905593A patent/SE446334B/sv unknown
- 1979-06-26 IL IL57662A patent/IL57662A/xx unknown
- 1979-06-26 AU AU48384/79A patent/AU526995B2/en not_active Expired
- 1979-06-26 GB GB7922194A patent/GB2028826B/en not_active Expired
- 1979-06-26 NO NO792137A patent/NO149733C/no unknown
- 1979-06-27 JP JP8196379A patent/JPS5543065A/ja active Granted
- 1979-06-27 ES ES482097A patent/ES482097A1/es not_active Expired
- 1979-06-27 AT AT0449679A patent/AT375335B/de not_active IP Right Cessation
- 1979-06-27 FR FR7916590A patent/FR2429776A1/fr active Granted
- 1979-06-27 NL NL7905015A patent/NL7905015A/nl not_active Application Discontinuation
- 1979-06-27 DE DE19792925945 patent/DE2925945A1/de active Granted
- 1979-06-27 LU LU81428A patent/LU81428A1/xx unknown
- 1979-06-27 BE BE0/195998A patent/BE877310A/xx not_active IP Right Cessation
- 1979-06-27 CA CA000330724A patent/CA1145765A/en not_active Expired
- 1979-08-08 IE IE1235/79A patent/IE48652B1/en not_active IP Right Cessation
-
1981
- 1981-12-28 US US06/334,604 patent/US4401827A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL7905015A (nl) | 1980-01-02 |
| SE7905593L (sv) | 1979-12-28 |
| IE791235L (en) | 1979-12-27 |
| GB2028826B (en) | 1982-11-03 |
| CA1145765A (en) | 1983-05-03 |
| IL57662A (en) | 1983-12-30 |
| CH640824A5 (it) | 1984-01-31 |
| BE877310A (fr) | 1979-10-15 |
| IT1156840B (it) | 1987-02-04 |
| ES482097A1 (es) | 1980-08-01 |
| NO149733B (no) | 1984-03-05 |
| AU526995B2 (en) | 1983-02-10 |
| GB2028826A (en) | 1980-03-12 |
| LU81428A1 (fr) | 1979-09-12 |
| DE2925945A1 (de) | 1980-01-10 |
| JPS5543065A (en) | 1980-03-26 |
| FR2429776A1 (fr) | 1980-01-25 |
| US4401827A (en) | 1983-08-30 |
| DK148300B (da) | 1985-06-03 |
| SE446334B (sv) | 1986-09-01 |
| JPH0211579B2 (de) | 1990-03-14 |
| IE48652B1 (en) | 1985-04-03 |
| IL57662A0 (en) | 1979-10-31 |
| NO149733C (no) | 1984-06-13 |
| IT7850065A0 (it) | 1978-06-27 |
| AU4838479A (en) | 1980-01-03 |
| DE2925945C2 (de) | 1991-06-27 |
| DK270079A (da) | 1979-12-28 |
| GR67648B (de) | 1981-09-01 |
| FR2429776B1 (de) | 1982-11-12 |
| AT375335B (de) | 1984-07-25 |
| NO792137L (no) | 1979-12-28 |
| DK148300C (da) | 1985-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELA | Expired due to lapse of time |