IT1122489B - Derivati di cloroambucile - Google Patents
Derivati di cloroambucileInfo
- Publication number
- IT1122489B IT1122489B IT25083/79A IT2508379A IT1122489B IT 1122489 B IT1122489 B IT 1122489B IT 25083/79 A IT25083/79 A IT 25083/79A IT 2508379 A IT2508379 A IT 2508379A IT 1122489 B IT1122489 B IT 1122489B
- Authority
- IT
- Italy
- Prior art keywords
- chlorambucile
- derivatives
- chlorambucile derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53098795A JPS5810393B2 (ja) | 1978-08-14 | 1978-08-14 | 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤 |
| JP15217578A JPS5810397B2 (ja) | 1978-12-08 | 1978-12-08 | 新規なエストラジオ−ル誘導体とその製造方法及び抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7925083A0 IT7925083A0 (it) | 1979-08-13 |
| IT1122489B true IT1122489B (it) | 1986-04-23 |
Family
ID=26439904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT25083/79A IT1122489B (it) | 1978-08-14 | 1979-08-13 | Derivati di cloroambucile |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US4261910A (it) |
| AU (1) | AU516722B2 (it) |
| CA (1) | CA1123427A (it) |
| CH (1) | CH641817A5 (it) |
| DE (1) | DE2932607C2 (it) |
| DK (1) | DK147145C (it) |
| ES (1) | ES483410A1 (it) |
| FR (1) | FR2433540A1 (it) |
| GB (1) | GB2028335B (it) |
| IT (1) | IT1122489B (it) |
| NL (1) | NL184684C (it) |
| PH (1) | PH16515A (it) |
| SE (1) | SE442016C (it) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261910A (en) * | 1978-08-14 | 1981-04-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | Process for the preparation of Chlorambucil derivatives |
| US4784960A (en) * | 1981-09-24 | 1988-11-15 | Peter S. Brune | Process for preparation of control for use in progesterone receptor |
| US4423151A (en) * | 1981-09-24 | 1983-12-27 | Peter S. Brune | Process for preparation of control for use in estrogen receptor tests |
| DE3210637A1 (de) * | 1982-03-23 | 1983-09-29 | Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg | Steroidester von n-(2-halogenethyl)-n-nitroso-carbamoylaminosaeuren und deren peptiden, sowie verfahren zu deren herstellung |
| DE3490749C2 (de) * | 1984-07-31 | 1989-12-28 | V Onkologiceskij Naucnyj Centr | 11-Desoxy-17alpha-hydroxycorticosteronester |
| JPS61293993A (ja) * | 1985-06-21 | 1986-12-24 | Kureha Chem Ind Co Ltd | 新規な螢光物質，その製造方法及び薬剤 |
| JPH0621072B2 (ja) * | 1986-11-12 | 1994-03-23 | 呉羽化学工業株式会社 | エストラジオ−ル誘導体よりなる免疫調節剤 |
| JPH0794377B2 (ja) * | 1987-07-22 | 1995-10-11 | 呉羽化学工業株式会社 | エストラジオール誘導体を含有する注射剤 |
| US4835182A (en) * | 1987-08-21 | 1989-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Enhancing drug delivery to the brain |
| JP2520074B2 (ja) * | 1992-06-11 | 1996-07-31 | 呉羽化学工業株式会社 | 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤 |
| JPH07101977A (ja) * | 1993-10-05 | 1995-04-18 | Kureha Chem Ind Co Ltd | ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤 |
| US20060019936A1 (en) * | 2004-03-10 | 2006-01-26 | Massachusetts Institute Of Technology | Methods and compositions for treating cancer |
| US20090130017A1 (en) * | 2007-11-19 | 2009-05-21 | Searete Llc | Targeted short-lived drug delivery |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1016959A (en) * | 1963-04-09 | 1966-01-12 | Leo Ab | Substituted steroid hormones |
| GB1272841A (en) * | 1969-01-23 | 1972-05-03 | Leo Ab | New corticoid steroid compounds of cytostatic interest |
| US4029778A (en) * | 1969-01-23 | 1977-06-14 | Aktiebolaget Leo | Cortical steroid nitrogen mustard compositions and treatment therewith |
| GB1458372A (en) * | 1973-03-05 | 1976-12-15 | Leo Ab | Steroid carbamates and allophanates |
| GB1558472A (en) * | 1976-01-22 | 1980-01-03 | Leo Ab | 17-esters of 17- hydroxy gestogens |
| GB1527161A (en) * | 1976-02-19 | 1978-10-04 | Leo A | Enol esters of steroids |
| GB1565680A (en) * | 1976-12-31 | 1980-04-23 | Leo Ab | Method for the preparation of carboxylic acid esters |
| US4261910A (en) * | 1978-08-14 | 1981-04-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | Process for the preparation of Chlorambucil derivatives |
-
1979
- 1979-08-01 US US06/062,789 patent/US4261910A/en not_active Expired - Lifetime
- 1979-08-03 PH PH22853A patent/PH16515A/en unknown
- 1979-08-10 AU AU49775/79A patent/AU516722B2/en not_active Ceased
- 1979-08-10 DE DE2932607A patent/DE2932607C2/de not_active Expired
- 1979-08-10 FR FR7920545A patent/FR2433540A1/fr active Granted
- 1979-08-13 CA CA333,654A patent/CA1123427A/en not_active Expired
- 1979-08-13 SE SE7906761A patent/SE442016C/sv not_active IP Right Cessation
- 1979-08-13 IT IT25083/79A patent/IT1122489B/it active
- 1979-08-13 CH CH740079A patent/CH641817A5/de not_active IP Right Cessation
- 1979-08-14 GB GB7928320A patent/GB2028335B/en not_active Expired
- 1979-08-14 DK DK340679A patent/DK147145C/da not_active IP Right Cessation
- 1979-08-14 ES ES483410A patent/ES483410A1/es not_active Expired
- 1979-08-14 NL NLAANVRAGE7906177,A patent/NL184684C/xx not_active IP Right Cessation
-
1980
- 1980-09-12 US US06/186,487 patent/US4332797A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CH641817A5 (de) | 1984-03-15 |
| NL184684B (nl) | 1989-05-01 |
| DE2932607C2 (de) | 1982-07-29 |
| NL7906177A (nl) | 1980-02-18 |
| DE2932607A1 (de) | 1980-02-21 |
| CA1123427A (en) | 1982-05-11 |
| AU4977579A (en) | 1980-02-21 |
| SE442016B (sv) | 1985-11-25 |
| IT7925083A0 (it) | 1979-08-13 |
| PH16515A (en) | 1983-11-08 |
| AU516722B2 (en) | 1981-06-18 |
| DK147145B (da) | 1984-04-24 |
| US4261910A (en) | 1981-04-14 |
| NL184684C (nl) | 1991-05-16 |
| DK340679A (da) | 1980-02-15 |
| SE442016C (sv) | 1992-06-01 |
| ES483410A1 (es) | 1980-04-16 |
| DK147145C (da) | 1984-10-15 |
| GB2028335A (en) | 1980-03-05 |
| FR2433540A1 (fr) | 1980-03-14 |
| GB2028335B (en) | 1982-12-15 |
| FR2433540B1 (it) | 1982-07-02 |
| US4332797A (en) | 1982-06-01 |
| SE7906761L (sv) | 1980-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950830 |